ID   OX26_BOVIN              Reviewed;         134 AA.
AC   P83862;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Orexigenic neuropeptide QRFP;
DE   Contains:
DE     RecName: Full=QRF-amide;
DE     AltName: Full=Neuropeptide RF-amide;
DE     AltName: Full=Pyroglutamylated arginine-phenylalanine-amide peptide;
DE   Flags: Precursor;
GN   Name=QRFP {ECO:0000312|EMBL:BAC98935.1};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000312|EMBL:BAC98935.1};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Hypothalamus {ECO:0000269|PubMed:12960173};
RX   PubMed=12960173; DOI=10.1074/jbc.m305270200;
RA   Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y.,
RA   Shintani Y., Hinuma S., Fujino M.;
RT   "A new peptidic ligand and its receptor regulating adrenal function in
RT   rats.";
RL   J. Biol. Chem. 278:46387-46395(2003).
CC   -!- FUNCTION: Stimulates feeding behavior, metabolic rate and locomotor
CC       activity and increases blood pressure. May have orexigenic activity.
CC       May promote aldosterone secretion by the adrenal gland (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Ligand for the G-protein coupled receptor QRFPR/GPR103.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed in the hypothalamus.
CC       {ECO:0000269|PubMed:12960173}.
CC   -!- SIMILARITY: Belongs to the RFamide neuropeptide family. {ECO:0000305}.
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DR   EMBL; AB109626; BAC98935.1; -; mRNA.
DR   RefSeq; NP_937865.1; NM_198222.1.
DR   AlphaFoldDB; P83862; -.
DR   STRING; 9913.ENSBTAP00000023922; -.
DR   PaxDb; P83862; -.
DR   GeneID; 379045; -.
DR   KEGG; bta:379045; -.
DR   CTD; 347148; -.
DR   eggNOG; ENOG502S84J; Eukaryota.
DR   InParanoid; P83862; -.
DR   OrthoDB; 1571514at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR   GO; GO:0031854; F:orexigenic neuropeptide QRFP receptor binding; ISS:UniProtKB.
DR   GO; GO:0007626; P:locomotory behavior; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR   GO; GO:0045777; P:positive regulation of blood pressure; ISS:UniProtKB.
DR   GO; GO:0060259; P:regulation of feeding behavior; ISS:UniProtKB.
DR   InterPro; IPR024565; P518.
DR   PANTHER; PTHR36476; PTHR36476; 1.
DR   Pfam; PF11109; RFamide_26RFa; 1.
PE   2: Evidence at transcript level;
KW   Amidation; Neuropeptide; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..88
FT                   /evidence="ECO:0000255, ECO:0000305"
FT                   /id="PRO_0000010084"
FT   PEPTIDE         89..131
FT                   /note="QRF-amide"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000010085"
FT   MOD_RES         131
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   134 AA;  14567 MW;  71463FAB9882EC6A CRC64;
     MRSPYSLPYL LFLPLGACFP VLDTEEPVDA VGGTGREMSW MDPARGRPFP WGSPGWPRAP
     YPHALLVTAK ELRASGKARA GFQLRLGRQD DGSEATGLLL GEAEKVGGLL GTLAEELNGY
     SRKKGGFSFR FGRR