ID   OX26_PELLE              Reviewed;          26 AA.
AC   P83683;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Orexigenic neuropeptide 26RFa;
OS   Pelophylax lessonae (Pool frog) (Rana lessonae).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX   NCBI_TaxID=45623 {ECO:0000305};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND
RP   AMIDATION AT PHE-26.
RC   TISSUE=Brain {ECO:0000269|PubMed:14657341};
RX   PubMed=14657341; DOI=10.1073/pnas.2434676100;
RA   Chartrel N., Dujardin C., Anouar Y., Leprince J., Decker A., Clerens S.,
RA   Do-Rego J.-C., Vandesande F., Llorens-Cortes C., Costentin J.,
RA   Beauvillain J.-C., Vaudry H.;
RT   "Identification of 26RFa, a hypothalamic neuropeptide of the RFamide
RT   peptide family with orexigenic activity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:15247-15252(2003).
CC   -!- FUNCTION: May have orexigenic activity. May promote aldosterone
CC       secretion by the adrenal gland. {ECO:0000269|PubMed:14657341}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Brain. {ECO:0000269|PubMed:14657341}.
CC   -!- MASS SPECTROMETRY: Mass=2828.3; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:14657341};
CC   -!- SIMILARITY: Belongs to the RFamide neuropeptide family. {ECO:0000305}.
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DR   AlphaFoldDB; P83683; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IDA:UniProtKB.
DR   GO; GO:0031854; F:orexigenic neuropeptide QRFP receptor binding; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IDA:UniProtKB.
DR   InterPro; IPR024565; P518.
DR   Pfam; PF11109; RFamide_26RFa; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Neuropeptide; Secreted.
FT   PEPTIDE         1..26
FT                   /note="Orexigenic neuropeptide 26RFa"
FT                   /id="PRO_0000043717"
FT   MOD_RES         26
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:14657341"
SQ   SEQUENCE   26 AA;  2819 MW;  2BAA5528A63C9D71 CRC64;
     VGTALGSLAE ELNGYNRKKG GFSFRF