OX26_RAT
ID OX26_RAT Reviewed; 124 AA.
AC P83860;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Orexigenic neuropeptide QRFP;
DE AltName: Full=P518;
DE Contains:
DE RecName: Full=QRF-amide;
DE AltName: Full=Neuropeptide RF-amide;
DE AltName: Full=Pyroglutamylated arginine-phenylalanine-amide peptide;
DE Flags: Precursor;
GN Name=Qrfp; Synonyms=P518;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000312|EMBL:AAR24355.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Brain {ECO:0000269|PubMed:12960173};
RX PubMed=12960173; DOI=10.1074/jbc.m305270200;
RA Fukusumi S., Yoshida H., Fujii R., Maruyama M., Komatsu H., Habata Y.,
RA Shintani Y., Hinuma S., Fujino M.;
RT "A new peptidic ligand and its receptor regulating adrenal function in
RT rats.";
RL J. Biol. Chem. 278:46387-46395(2003).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=Wistar {ECO:0000312|EMBL:AAR24355.1};
RC TISSUE=Hypothalamus {ECO:0000312|EMBL:AAR24355.1};
RX PubMed=14657341; DOI=10.1073/pnas.2434676100;
RA Chartrel N., Dujardin C., Anouar Y., Leprince J., Decker A., Clerens S.,
RA Do-Rego J.-C., Vandesande F., Llorens-Cortes C., Costentin J.,
RA Beauvillain J.-C., Vaudry H.;
RT "Identification of 26RFa, a hypothalamic neuropeptide of the RFamide
RT peptide family with orexigenic activity.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:15247-15252(2003).
RN [3]
RP PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION, PYROGLUTAMATE FORMATION AT
RP GLN-80, AND AMIDATION AT PHE-122.
RX PubMed=16648250; DOI=10.1073/pnas.0602371103;
RA Takayasu S., Sakurai T., Iwasaki S., Teranishi H., Yamanaka A.,
RA Williams S.C., Iguchi H., Kawasawa Y.I., Ikeda Y., Sakakibara I., Ohno K.,
RA Ioka R.X., Murakami S., Dohmae N., Xie J., Suda T., Motoike T., Ohuchi T.,
RA Yanagisawa M., Sakai J.;
RT "A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates
RT feeding, behavioral arousal, and blood pressure in mice.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7438-7443(2006).
CC -!- FUNCTION: Stimulates feeding and grooming behavior, metabolic rate and
CC locomotor activity and increases blood pressure. May have orexigenic
CC activity. May promote aldosterone secretion by the adrenal gland.
CC {ECO:0000269|PubMed:16648250}.
CC -!- SUBUNIT: Ligand for the G-protein coupled receptor QRFPR/GPR103.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in the brain with highest expression
CC levels in the hypothalamus and optic nerve. Also expressed in the
CC trachea and mammary gland. {ECO:0000269|PubMed:12960173,
CC ECO:0000269|PubMed:14657341}.
CC -!- SIMILARITY: Belongs to the RFamide neuropeptide family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB109627; BAC98936.1; -; mRNA.
DR EMBL; AY438327; AAR24355.1; -; mRNA.
DR RefSeq; NP_937843.1; NM_198200.1.
DR RefSeq; XP_003749488.1; XM_003749440.3.
DR RefSeq; XP_008759893.1; XM_008761671.2.
DR AlphaFoldDB; P83860; -.
DR STRING; 10116.ENSRNOP00000064225; -.
DR PaxDb; P83860; -.
DR Ensembl; ENSRNOT00000073731; ENSRNOP00000066916; ENSRNOG00000046473.
DR GeneID; 379044; -.
DR KEGG; rno:379044; -.
DR UCSC; RGD:735020; rat.
DR CTD; 347148; -.
DR RGD; 735020; Qrfp.
DR eggNOG; ENOG502S84J; Eukaryota.
DR GeneTree; ENSGT00390000015756; -.
DR HOGENOM; CLU_155319_0_0_1; -.
DR InParanoid; P83860; -.
DR OMA; PLGTCFP; -.
DR OrthoDB; 1571514at2759; -.
DR PhylomeDB; P83860; -.
DR TreeFam; TF336317; -.
DR Reactome; R-RNO-389397; Orexin and neuropeptides FF and QRFP bind to their respective receptors.
DR Reactome; R-RNO-416476; G alpha (q) signalling events.
DR PRO; PR:P83860; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Genevisible; P83860; RN.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IMP:RGD.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR GO; GO:0031854; F:orexigenic neuropeptide QRFP receptor binding; ISS:UniProtKB.
DR GO; GO:0007625; P:grooming behavior; ISS:UniProtKB.
DR GO; GO:0007626; P:locomotory behavior; ISS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR GO; GO:0045777; P:positive regulation of blood pressure; ISS:UniProtKB.
DR GO; GO:0060259; P:regulation of feeding behavior; ISS:UniProtKB.
DR InterPro; IPR024565; P518.
DR PANTHER; PTHR36476; PTHR36476; 1.
DR Pfam; PF11109; RFamide_26RFa; 1.
PE 1: Evidence at protein level;
KW Amidation; Direct protein sequencing; Neuropeptide;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT PROPEP 18..79
FT /evidence="ECO:0000250"
FT /id="PRO_0000010090"
FT PEPTIDE 80..122
FT /note="QRF-amide"
FT /evidence="ECO:0000269|PubMed:16648250"
FT /id="PRO_0000010091"
FT REGION 63..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 80
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:16648250"
FT MOD_RES 122
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:16648250"
SQ SEQUENCE 124 AA; 13653 MW; 6909C0AA4394F896 CRC64;
MRCLCSWLCL LLPLSACFPL LDRRGPTDIG DIGARMSWVQ LTEGHTPRSV QSPRPQALLV
VAKEQQASRR EHTGFRLGRQ DSGSEATGFL PTDSEKASGP LGTLAEELSS YSRRKGGFSF
RFGR
