ID   OX2V_HHV6Z              Reviewed;         292 AA.
AC   Q9QJ17;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   02-JUN-2021, entry version 66.
DE   RecName: Full=Putative OX-2 membrane glycoprotein homolog;
DE   AltName: Full=Protein U85;
DE   Flags: Precursor;
GN   Name=U85;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- SUBCELLULAR LOCATION: Host membrane; Single-pass membrane protein.
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DR   EMBL; AF157706; AAD49673.1; -; Genomic_DNA.
DR   RefSeq; NP_050264.1; NC_000898.1.
DR   PRIDE; Q9QJ17; -.
DR   DNASU; 1497085; -.
DR   GeneID; 1497085; -.
DR   KEGG; vg:1497085; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Host membrane; Immunoglobulin domain;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000250"
FT   CHAIN           19..292
FT                   /note="Putative OX-2 membrane glycoprotein homolog"
FT                   /id="PRO_0000408408"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          24..136
FT                   /note="Ig-like V-type"
FT   DOMAIN          147..237
FT                   /note="Ig-like C2-type"
FT   CARBOHYD        45
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        57
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        72
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        195
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
FT   DISULFID        42..126
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   292 AA;  33120 MW;  B10F291780B78C13 CRC64;
     MSPLMLRLLP LLCIIISAHF VPRPETSPSL VYEIGSTVTF HCRLNTTTNI QSVSWYNKSR
     LISNHEIQNM DNLSFTDDGY VFIHELNKIN NLDVDSKLYF HIKHDRTTSL LKIKARSAYD
     ATCLTCTFTV DNEKTSATSC LKLIMKPIVV LYFRYLNNFL DVTCTVTSYP KPNVVIKFLG
     EVYKRDIPMV RQNENGSSTV SVSFTFKRRT KLEFVGKTIS CLASSWFTNQ KASALVTSGE
     HTVQNHDEYS KEAVKGSNSD ETVFTWIVPL ILILIISVMV LLISMCIVAF KS