OXA11_SCHPO
ID OXA11_SCHPO Reviewed; 374 AA.
AC O14300;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Mitochondrial inner membrane protein oxa1-1;
DE AltName: Full=Cytochrome oxidase biogenesis protein 1-1;
DE Short=Sp1;
DE Flags: Precursor;
GN Name=oxa101; Synonyms=oxa1-1; ORFNames=SPAC9G1.04;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=972 / ATCC 24843;
RX PubMed=10712694; DOI=10.1046/j.1365-2958.2000.01781.x;
RA Bonnefoy N., Kermorgant M., Groudinsky O., Dujardin G.;
RT "The respiratory gene OXA1 has two fission yeast orthologues which together
RT encode a function essential for cellular viability.";
RL Mol. Microbiol. 35:1135-1145(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Required for the insertion of integral membrane proteins into
CC the mitochondrial inner membrane. Essential for the activity and
CC assembly of cytochrome c oxidase. Not essential for viability, while
CC oxa102 is essential. When both genes are deleted the cell is non-
CC viable, suggesting that oxa101 act as a back-up for oxa102.
CC {ECO:0000269|PubMed:10712694}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. {ECO:0000305}.
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DR EMBL; X94123; CAA63843.1; -; mRNA.
DR EMBL; CU329670; CAB11488.1; -; Genomic_DNA.
DR PIR; T43708; T43708.
DR RefSeq; NP_593559.1; NM_001018992.2.
DR AlphaFoldDB; O14300; -.
DR BioGRID; 279321; 3.
DR STRING; 4896.SPAC9G1.04.1; -.
DR iPTMnet; O14300; -.
DR SwissPalm; O14300; -.
DR MaxQB; O14300; -.
DR PaxDb; O14300; -.
DR PRIDE; O14300; -.
DR EnsemblFungi; SPAC9G1.04.1; SPAC9G1.04.1:pep; SPAC9G1.04.
DR GeneID; 2542876; -.
DR KEGG; spo:SPAC9G1.04; -.
DR PomBase; SPAC9G1.04; oxa101.
DR VEuPathDB; FungiDB:SPAC9G1.04; -.
DR eggNOG; KOG1239; Eukaryota.
DR HOGENOM; CLU_029282_3_2_1; -.
DR InParanoid; O14300; -.
DR OMA; PWWVSII; -.
DR PhylomeDB; O14300; -.
DR PRO; PR:O14300; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0032977; F:membrane insertase activity; ISO:PomBase.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; ISO:PomBase.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..374
FT /note="Mitochondrial inner membrane protein oxa1-1"
FT /id="PRO_0000020358"
FT TOPO_DOM ?..76
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..159
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..242
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..374
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
SQ SEQUENCE 374 AA; 42060 MW; 989314857793402D CRC64;
MLHFLIRPST RCAGSPHFNS TSSFLRKRLQ SKTILSKRLG FQFRPSSTNV LAEVSTATSG
FNPSWWPYAL IQNTAYTINV YAGAPWWVSI ILTTLGVRLA LTPVMIASFR NSTKLSVIQP
EMKKELEAIK TAKLDNDQLA LNQHSIALRG IYLKHNVNPF AIFILPLTQS AVFFSFFYAI
RKMSRLSVDG FTTGGLAWFK DLSIPDPYCI LPIINAGLMF SGMQMNRANT ASTIGNSTNW
RTFFFLCCLL SPLLTAKLPA AIFMYWIPSS LFNIVQGYIL KNPVVRSKLG FAPLPSIIEK
QPSGFTLITN PIKSLKEFYK GVRDGFKTQY EQLQKDVSRR AVATTSASTI RPNSHYKKLK
ELNRSKKNSK KQSN
