OXA1_ARATH
ID OXA1_ARATH Reviewed; 429 AA.
AC Q42191; Q42190;
DT 14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Mitochondrial inner membrane protein OXA1;
DE AltName: Full=Oxidase assembly 1 protein;
DE Short=AtOXA1;
DE Flags: Precursor;
GN Name=OXA1; Synonyms=ATOXA1; OrderedLocusNames=At5g62050; ORFNames=MTG10.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia; TISSUE=Seedling;
RX PubMed=9450344; DOI=10.1046/j.1365-313x.1997.12061319.x;
RA Hamel P., Sakamoto W., Wintz H., Dujardin G.;
RT "Functional complementation of an oxa1- yeast mutation identifies an
RT Arabidopsis thaliana cDNA involved in the assembly of respiratory
RT complexes.";
RL Plant J. 12:1319-1327(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=11148275; DOI=10.1093/pcp/pcd045;
RA Sakamoto W., Spielewoy N., Bonnard G., Murata M., Wintz H.;
RT "Mitochondrial localization of AtOXA1, an Arabidopsis homologue of yeast
RT Oxa1p involved in the insertion and assembly of protein complexes in
RT mitochondrial inner membrane.";
RL Plant Cell Physiol. 41:1157-1163(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 268-367 AND 386-429.
RC STRAIN=cv. Columbia; TISSUE=Shoot;
RX PubMed=8580968; DOI=10.1046/j.1365-313x.1996.09010101.x;
RA Cooke R., Raynal M., Laudie M., Grellet F., Delseny M., Morris P.-C.,
RA Guerrier D., Giraudat J., Quigley F., Clabault G., Li Y.-F., Mache R.,
RA Krivitzky M., Gy I.J.-J., Kreis M., Lecharny A., Parmentier Y., Marbach J.,
RA Fleck J., Clement B., Philipps G., Herve C., Bardet C., Tremousaygue D.,
RA Lescure B., Lacomme C., Roby D., Jourjon M.-F., Chabrier P.,
RA Charpenteau J.-L., Desprez T., Amselem J., Chiapello H., Hoefte H.;
RT "Further progress towards a catalogue of all Arabidopsis genes: analysis of
RT a set of 5000 non-redundant ESTs.";
RL Plant J. 9:101-124(1996).
CC -!- FUNCTION: Required for the insertion of integral membrane proteins into
CC the mitochondrial inner membrane. Essential for activity and assembly
CC of cytochrome c oxidase. {ECO:0000269|PubMed:9450344}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:11148275}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:11148275}.
CC -!- TISSUE SPECIFICITY: Expressed in stem, leaf and flower.
CC {ECO:0000269|PubMed:9450344}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC (TC 2.A.9.2) family.
CC {ECO:0000305}.
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DR EMBL; Y11871; CAA72619.1; -; mRNA.
DR EMBL; AB035892; BAA88473.1; -; Genomic_DNA.
DR EMBL; AB016880; BAB10166.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97555.1; -; Genomic_DNA.
DR EMBL; AY140006; AAM98148.1; -; mRNA.
DR EMBL; BT006574; AAP31918.1; -; mRNA.
DR EMBL; AY088837; AAM67144.1; -; mRNA.
DR EMBL; Z29024; CAA82287.1; -; mRNA.
DR EMBL; Z29025; CAA82288.1; -; mRNA.
DR RefSeq; NP_201011.1; NM_125598.4.
DR AlphaFoldDB; Q42191; -.
DR SMR; Q42191; -.
DR STRING; 3702.AT5G62050.1; -.
DR iPTMnet; Q42191; -.
DR PaxDb; Q42191; -.
DR PRIDE; Q42191; -.
DR ProteomicsDB; 248855; -.
DR EnsemblPlants; AT5G62050.1; AT5G62050.1; AT5G62050.
DR GeneID; 836325; -.
DR Gramene; AT5G62050.1; AT5G62050.1; AT5G62050.
DR KEGG; ath:AT5G62050; -.
DR Araport; AT5G62050; -.
DR TAIR; locus:2174068; AT5G62050.
DR eggNOG; KOG1239; Eukaryota.
DR HOGENOM; CLU_029282_4_0_1; -.
DR InParanoid; Q42191; -.
DR OMA; KNAEMAH; -.
DR OrthoDB; 1314061at2759; -.
DR PhylomeDB; Q42191; -.
DR PRO; PR:Q42191; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q42191; baseline and differential.
DR Genevisible; Q42191; AT.
DR GO; GO:0031305; C:integral component of mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; IDA:TAIR.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; IBA:GO_Central.
DR InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR PANTHER; PTHR12428; PTHR12428; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..?
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN ?..429
FT /note="Mitochondrial inner membrane protein OXA1"
FT /id="PRO_0000020363"
FT TOPO_DOM ?..116
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..142
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..223
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..269
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..309
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..330
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 331..429
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT REGION 378..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 429 AA; 47860 MW; EDFF434DE689A007 CRC64;
MAFRQTLSIR SRLFARRNQP VYHIIPRESD HERDSFCQET SQRSYHSFLH QRSVNNSDFS
KVSGGSLHLP LAPTSGFAFY RYMSSAPGVG SEKIGVMSDI AEVITDSTLQ DVPAQAAAAV
SEVTLAAADS FFPIAALQQC IDMVHTFTGF EWWASIVVAT ILIRSSTVPL LIKQMKDTTK
LALMRPRLES IREEMQNKGM DSVTMAEGQK KMKNLFKEYG VTPFTPMKGM FIQGPLFICF
FLAIRNMAEK VPSFQTGGAL WFTDLTTPDS LYILPVITGL TFLITVECNA QEGMEGNPMA
GTVKTVCRVF ALLTVPMTMS FPQAIFCYWI TSNLFSLMYG LVIKRPQVKK MLRIPDLPPP
PPGQQPSFDL FSALKKMKAM TQDHTQNQIE PPSPVNPRLS STSLSPVSKR LKALESQVKG
RKKNSSKKK
