ID   OXA1_KAZSE              Reviewed;         371 AA.
AC   O13375;
DT   14-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Mitochondrial inner membrane protein OXA1;
DE   AltName: Full=Cytochrome oxidase biogenesis protein OXA1;
DE   AltName: Full=Oxidase assembly protein 1;
DE   Flags: Precursor;
GN   Name=OXA1;
OS   Kazachstania servazzii (Yeast) (Saccharomyces servazzii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kazachstania.
OX   NCBI_TaxID=27293;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 58439 / CBS 4311 / JCM 5179 / NBRC 18 38 / NRRL Y-12661;
RX   PubMed=10757749; DOI=10.1093/genetics/154.3.999;
RA   Costanzo M.C., Bonnefoy N., Williams E.H., Clark-Walker G.D., Fox T.D.;
RT   "Highly diverged homologs of Saccharomyces cerevisiae mitochondrial mRNA-
RT   specific translational activators have orthologous functions in other
RT   budding yeasts.";
RL   Genetics 154:999-1012(2000).
CC   -!- FUNCTION: Probably required for the insertion of integral membrane
CC       proteins into the mitochondrial inner membrane. Essential for the
CC       activity and assembly of cytochrome c oxidase (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF026395; AAB82601.1; -; Genomic_DNA.
DR   AlphaFoldDB; O13375; -.
DR   SMR; O13375; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Transit peptide;
KW   Transmembrane; Transmembrane helix.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..371
FT                   /note="Mitochondrial inner membrane protein OXA1"
FT                   /id="PRO_0000020361"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   371 AA;  42049 MW;  CF8A9BBDA3DC22BE CRC64;
     MGVANTSLRY SAFNFSLGRR FKSTSETLND LPETISEVQT QLPSIDQMTN ATADIVEQAS
     HSVGELSTHI GYLNSIGLAQ TWHWPADIIQ HALEYVHVYT GLPWWGTICT VTILVRLLMF
     PIYVKSSDTI AKNSRIKPQM DKVTKELMAT TDLAEGQKIA VRRRKLLSEN GIKNRWLAAP
     MLQLPIAIGF FNALRSMANF PVDGFANQGI LWFHDLTLSD PYLGLQFITA AVLMSFSRLG
     GETGAQQFSG PMKRFFIILP LVSIPATMNL STSVVLYFAI NGTFSVLQTL VLRNKWFRKK
     LNIAEVVQHP PDPTKENSGI FAAIKENMNT ARERSEKRKL MKEEEERVHE LIKKKRTNER
     IRIIRRPELK K