ID   OXAA_AQUAE              Reviewed;         502 AA.
AC   O66561;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Membrane protein insertase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Foldase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane integrase YidC {ECO:0000255|HAMAP-Rule:MF_01810};
DE   AltName: Full=Membrane protein YidC {ECO:0000255|HAMAP-Rule:MF_01810};
GN   Name=yidC {ECO:0000255|HAMAP-Rule:MF_01810}; OrderedLocusNames=aq_175;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC       complex formation of integral membrane proteins into the membrane.
CC       Involved in integration of membrane proteins that insert both
CC       dependently and independently of the Sec translocase complex, as well
CC       as at least some lipoproteins. Aids folding of multispanning membrane
CC       proteins. {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC       Specifically interacts with transmembrane segments of nascent integral
CC       membrane proteins during membrane integration. {ECO:0000255|HAMAP-
CC       Rule:MF_01810}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01810};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01810}.
CC   -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_01810}.
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DR   EMBL; AE000657; AAC06534.1; -; Genomic_DNA.
DR   PIR; F70316; F70316.
DR   RefSeq; NP_213121.1; NC_000918.1.
DR   RefSeq; WP_010880059.1; NC_000918.1.
DR   AlphaFoldDB; O66561; -.
DR   SMR; O66561; -.
DR   STRING; 224324.aq_175; -.
DR   EnsemblBacteria; AAC06534; AAC06534; aq_175.
DR   KEGG; aae:aq_175; -.
DR   PATRIC; fig|224324.8.peg.151; -.
DR   eggNOG; COG0706; Bacteria.
DR   HOGENOM; CLU_016535_3_1_0; -.
DR   InParanoid; O66561; -.
DR   OMA; WITPSSD; -.
DR   OrthoDB; 524437at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0032977; F:membrane insertase activity; IBA:GO_Central.
DR   GO; GO:0051205; P:protein insertion into membrane; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   HAMAP; MF_01810; YidC_type1; 1.
DR   InterPro; IPR019998; Membr_insert_YidC.
DR   InterPro; IPR028055; Membr_insert_YidC/Oxa1_C.
DR   InterPro; IPR028053; Membr_insert_YidC_N.
DR   InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR   PANTHER; PTHR12428; PTHR12428; 1.
DR   Pfam; PF02096; 60KD_IMP; 1.
DR   PRINTS; PR01900; YIDCPROTEIN.
DR   TIGRFAMs; TIGR03593; yidC_nterm; 1.
DR   TIGRFAMs; TIGR03592; yidC_oxa1_cterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chaperone; Membrane; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..502
FT                   /note="Membrane protein insertase YidC"
FT                   /id="PRO_0000124686"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        286..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        312..332
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
FT   TRANSMEM        452..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01810"
SQ   SEQUENCE   502 AA;  58225 MW;  6C24B8405F2570AD CRC64;
     MMDNDNQFWK RFLIFTILMF LFITAYELFY IYYVKPSQPQ KTEKKEVVKK EEFKNVNLPQ
     LMLGTFREKQ EYKNTKTVKL GIYSLELSEK GGKILRFIDQ KYGFDLISKA ERELKIFPLE
     IFTGNPDLDQ KLNFGEYEIK EGKNSVELIH KELKVKKILS YKNGAIHLSV EGLKPPFWVF
     VGSPPDDEAF YTHVGPVLKI NGEVVRLDVD DLKGINEFEG NIEFGGEESR YFFKGAKDYQ
     KHIVYKVKLG DKFVSLSTFL YDGEKTIYLG AKDYARLREL GLVDTLDWGT LKIIVKPLFL
     FLYWIYEHTG SWVLSILVLT FIVRIFLFPL GYKSVVSMQK LQELAPKMEK IKQKYKDDPV
     KMQEEMMKLY AETGFNPMAG CLPILLQIPI FFALYKVLII TVDLKVSSFL WIPSLADKDP
     YYILPVIMGL TMILQQKMTP SPDPKQALVG YITSVAFTLL FINFPAGLVL YWTLNNVFNI
     IQNYLIKEVL LKDKSKGGSK KK