位置:首页 > 蛋白库 > OXDA_CAVPO
OXDA_CAVPO
ID   OXDA_CAVPO              Reviewed;         347 AA.
AC   Q9Z1M5;
DT   27-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=D-amino-acid oxidase;
DE            Short=DAAO;
DE            Short=DAMOX;
DE            Short=DAO;
DE            EC=1.4.3.3;
GN   Name=DAO;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hartley; TISSUE=Cerebellum;
RX   PubMed=10376208; DOI=10.3109/10425179909008422;
RA   Konno R., Kurabayashi A., Tsuchiya M., Niwa A.;
RT   "Guinea pig D-amino acid oxidase cDNA and phylogenetic position.";
RL   DNA Seq. 10:85-91(1999).
CC   -!- FUNCTION: Regulates the level of the neuromodulator D-serine in the
CC       brain. Has high activity towards D-DOPA and contributes to dopamine
CC       synthesis. Could act as a detoxifying agent which removes D-amino acids
CC       accumulated during aging. Acts on a variety of D-amino acids with a
CC       preference for those having small hydrophobic side chains followed by
CC       those bearing polar, aromatic, and basic groups. Does not act on acidic
CC       amino acids (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a D-alpha-amino acid + H2O + O2 = a 2-oxocarboxylate + H2O2 +
CC         NH4(+); Xref=Rhea:RHEA:21816, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:28938, ChEBI:CHEBI:35179,
CC         ChEBI:CHEBI:59871; EC=1.4.3.3;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DAMOX/DASOX family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ007710; CAA07616.1; -; mRNA.
DR   RefSeq; NP_001166518.1; NM_001173047.1.
DR   AlphaFoldDB; Q9Z1M5; -.
DR   SMR; Q9Z1M5; -.
DR   STRING; 10141.ENSCPOP00000007341; -.
DR   Ensembl; ENSCPOT00000034560; ENSCPOP00000027474; ENSCPOG00000008164.
DR   GeneID; 100192327; -.
DR   KEGG; cpoc:100192327; -.
DR   CTD; 1610; -.
DR   eggNOG; KOG3923; Eukaryota.
DR   GeneTree; ENSGT00390000018635; -.
DR   HOGENOM; CLU_034311_0_1_1; -.
DR   InParanoid; Q9Z1M5; -.
DR   OMA; LWWPYRI; -.
DR   OrthoDB; 1363414at2759; -.
DR   TreeFam; TF313887; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000008164; Expressed in adult mammalian kidney and 4 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:Ensembl.
DR   GO; GO:0003884; F:D-amino-acid oxidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071949; F:FAD binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0055130; P:D-alanine catabolic process; IEA:Ensembl.
DR   GO; GO:0036088; P:D-serine catabolic process; IEA:Ensembl.
DR   GO; GO:0042416; P:dopamine biosynthetic process; IEA:Ensembl.
DR   GO; GO:0006562; P:proline catabolic process; IEA:Ensembl.
DR   InterPro; IPR006181; D-amino_acid_oxidase_CS.
DR   InterPro; IPR023209; DAO.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   PANTHER; PTHR11530; PTHR11530; 1.
DR   Pfam; PF01266; DAO; 1.
DR   PIRSF; PIRSF000189; D-aa_oxidase; 1.
DR   PROSITE; PS00677; DAO; 1.
PE   2: Evidence at transcript level;
KW   FAD; Flavoprotein; Oxidoreductase; Peroxisome; Reference proteome.
FT   CHAIN           1..347
FT                   /note="D-amino-acid oxidase"
FT                   /id="PRO_0000162759"
FT   MOTIF           345..347
FT                   /note="Microbody targeting signal"
FT                   /evidence="ECO:0000250"
FT   BINDING         3..17
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         37..38
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         44..45
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         49..51
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         53
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         164
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         182
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         217
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         228
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         283
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         312..316
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         313
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         317
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   347 AA;  39284 MW;  3B86E534272057C4 CRC64;
     MRVVVIGAGV IGLSTALCIC ERYHSVLQQL DLRVYADRFT PLTNTDVAAG LWQPYLSGPD
     NPQEVEWNQQ TFDYLLSHIH SPNAEQMGLA LVSGYNLFRE AVPDPFWKNM VLGFRKLTPR
     ELDVFPDYGY GWFHTSLIIE GKSYLAWLTE RLTERGVKFF QRKVESLEEV ARGGADVIIN
     CTGVWAGALQ PDPLLQPGRG QIIKVNAPWI KHFILTHDPE RGIYKSPYII PGIQEVTLGG
     IFQLGNWNEI NSTQDHNTIW KGCCSLEPTL RNARIVGEYT GFRPVRPQLR LEREQLRVGS
     ANTEVIHNYG HGGYGLTIHW GCALEAAKLF GKILEEKELY RMPPSHL
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2025