OXER1_HUMAN
ID OXER1_HUMAN Reviewed; 423 AA.
AC Q8TDS5; Q86WP7; Q8NGW4;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Oxoeicosanoid receptor 1;
DE AltName: Full=5-oxo-ETE G-protein coupled receptor;
DE AltName: Full=G-protein coupled receptor 170;
DE AltName: Full=G-protein coupled receptor R527;
DE AltName: Full=G-protein coupled receptor TG1019;
GN Name=OXER1; Synonyms=GPR170, TG1019;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=12065583; DOI=10.1074/jbc.m203194200;
RA Hosoi T., Koguchi Y., Sugikawa E., Chikada A., Ogawa K., Tsuda N., Suto N.,
RA Tsunoda S., Taniguchi T., Ohnuki T.;
RT "Identification of a novel human eicosanoid receptor coupled to G(i/o).";
RL J. Biol. Chem. 277:31459-31465(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND VARIANT
RP VAL-407.
RX PubMed=12606753; DOI=10.1124/mol.63.3.471;
RA Jones C.E., Holden S., Tenaillon L., Bhatia U., Seuwen K., Tranter P.,
RA Turner J., Kettle R., Bouhelal R., Charlton S., Nirmala N.R., Jarai G.,
RA Finan P.;
RT "Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic
RT acid receptor highly expressed on human eosinophils and neutrophils.";
RL Mol. Pharmacol. 63:471-477(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for eicosanoids and polyunsaturated fatty acids such
CC as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-
CC hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and
CC arachidonic acid. Seems to be coupled to the G(i)/G(o), families of
CC heteromeric G proteins. {ECO:0000269|PubMed:12065583,
CC ECO:0000269|PubMed:12606753}.
CC -!- INTERACTION:
CC Q8TDS5; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-12813389, EBI-12224467;
CC Q8TDS5; Q8WXK3-2: ASB13; NbExp=3; IntAct=EBI-12813389, EBI-12015080;
CC Q8TDS5; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-12813389, EBI-12006308;
CC Q8TDS5; O75909-2: CCNK; NbExp=3; IntAct=EBI-12813389, EBI-12010594;
CC Q8TDS5; P53672: CRYBA2; NbExp=3; IntAct=EBI-12813389, EBI-750444;
CC Q8TDS5; Q8N7B9-2: EFCAB3; NbExp=3; IntAct=EBI-12813389, EBI-11958551;
CC Q8TDS5; Q6NXG1: ESRP1; NbExp=3; IntAct=EBI-12813389, EBI-10213520;
CC Q8TDS5; O75593: FOXH1; NbExp=3; IntAct=EBI-12813389, EBI-1759806;
CC Q8TDS5; P35680: HNF1B; NbExp=3; IntAct=EBI-12813389, EBI-2798841;
CC Q8TDS5; P31943: HNRNPH1; NbExp=3; IntAct=EBI-12813389, EBI-351590;
CC Q8TDS5; Q5TA45: INTS11; NbExp=3; IntAct=EBI-12813389, EBI-748258;
CC Q8TDS5; P0C870: JMJD7; NbExp=3; IntAct=EBI-12813389, EBI-9090173;
CC Q8TDS5; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-12813389, EBI-11953334;
CC Q8TDS5; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-12813389, EBI-1048945;
CC Q8TDS5; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-12813389, EBI-10172511;
CC Q8TDS5; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-12813389, EBI-10250562;
CC Q8TDS5; Q14847-2: LASP1; NbExp=3; IntAct=EBI-12813389, EBI-9088686;
CC Q8TDS5; Q71SY5: MED25; NbExp=3; IntAct=EBI-12813389, EBI-394558;
CC Q8TDS5; P62166: NCS1; NbExp=3; IntAct=EBI-12813389, EBI-746987;
CC Q8TDS5; Q86SG6: NEK8; NbExp=3; IntAct=EBI-12813389, EBI-1752987;
CC Q8TDS5; Q9BVI4: NOC4L; NbExp=3; IntAct=EBI-12813389, EBI-395927;
CC Q8TDS5; P32242: OTX1; NbExp=3; IntAct=EBI-12813389, EBI-740446;
CC Q8TDS5; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-12813389, EBI-769257;
CC Q8TDS5; O43741: PRKAB2; NbExp=3; IntAct=EBI-12813389, EBI-1053424;
CC Q8TDS5; O75360: PROP1; NbExp=3; IntAct=EBI-12813389, EBI-9027467;
CC Q8TDS5; P86480: PRR20D; NbExp=3; IntAct=EBI-12813389, EBI-12754095;
CC Q8TDS5; P0CG20: PRR35; NbExp=3; IntAct=EBI-12813389, EBI-11986293;
CC Q8TDS5; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-12813389, EBI-744023;
CC Q8TDS5; O43251-10: RBFOX2; NbExp=3; IntAct=EBI-12813389, EBI-11963050;
CC Q8TDS5; Q6P9E2: RECK; NbExp=3; IntAct=EBI-12813389, EBI-10253121;
CC Q8TDS5; Q9H0X6: RNF208; NbExp=3; IntAct=EBI-12813389, EBI-751555;
CC Q8TDS5; Q9H0F5: RNF38; NbExp=3; IntAct=EBI-12813389, EBI-2341200;
CC Q8TDS5; Q7L0R7: RNF44; NbExp=3; IntAct=EBI-12813389, EBI-2845060;
CC Q8TDS5; Q92734: TFG; NbExp=3; IntAct=EBI-12813389, EBI-357061;
CC Q8TDS5; Q08117-2: TLE5; NbExp=3; IntAct=EBI-12813389, EBI-11741437;
CC Q8TDS5; Q12888: TP53BP1; NbExp=3; IntAct=EBI-12813389, EBI-396540;
CC Q8TDS5; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-12813389, EBI-11957216;
CC Q8TDS5; A0A0C4DGF1: ZBTB32; NbExp=3; IntAct=EBI-12813389, EBI-10188476;
CC Q8TDS5; Q96K80: ZC3H10; NbExp=3; IntAct=EBI-12813389, EBI-742550;
CC Q8TDS5; Q15915: ZIC1; NbExp=3; IntAct=EBI-12813389, EBI-11963196;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in various tissues except brain.
CC Expression is more intense in liver, kidney, peripheral leukocyte,
CC lung, and spleen than in other tissues. Highly expressed in
CC eosinophils, neutrophils, and lung macrophages.
CC {ECO:0000269|PubMed:12065583, ECO:0000269|PubMed:12606753}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO17739.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC05878.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB083055; BAC11806.2; -; mRNA.
DR EMBL; AY158687; AAO17739.1; ALT_INIT; mRNA.
DR EMBL; AB065652; BAC05878.1; ALT_INIT; Genomic_DNA.
DR EMBL; AB083630; BAB89343.1; -; Genomic_DNA.
DR EMBL; AC098824; AAY14700.1; -; Genomic_DNA.
DR EMBL; BC063549; AAH63549.1; -; mRNA.
DR RefSeq; NP_683765.1; NM_148962.4.
DR AlphaFoldDB; Q8TDS5; -.
DR SMR; Q8TDS5; -.
DR BioGRID; 127909; 48.
DR IntAct; Q8TDS5; 42.
DR STRING; 9606.ENSP00000367930; -.
DR BindingDB; Q8TDS5; -.
DR ChEMBL; CHEMBL1628461; -.
DR DrugCentral; Q8TDS5; -.
DR GuidetoPHARMACOLOGY; 271; -.
DR SwissLipids; SLP:000001564; -.
DR GlyGen; Q8TDS5; 1 site.
DR iPTMnet; Q8TDS5; -.
DR PhosphoSitePlus; Q8TDS5; -.
DR BioMuta; OXER1; -.
DR DMDM; 74762623; -.
DR PaxDb; Q8TDS5; -.
DR PeptideAtlas; Q8TDS5; -.
DR PRIDE; Q8TDS5; -.
DR ProteomicsDB; 74336; -.
DR Antibodypedia; 14829; 253 antibodies from 33 providers.
DR DNASU; 165140; -.
DR Ensembl; ENST00000378661.3; ENSP00000367930.2; ENSG00000162881.6.
DR GeneID; 165140; -.
DR KEGG; hsa:165140; -.
DR MANE-Select; ENST00000378661.4; ENSP00000367930.3; NM_148962.5; NP_683765.2.
DR UCSC; uc002rss.4; human.
DR CTD; 165140; -.
DR DisGeNET; 165140; -.
DR GeneCards; OXER1; -.
DR HGNC; HGNC:24884; OXER1.
DR HPA; ENSG00000162881; Tissue enriched (liver).
DR neXtProt; NX_Q8TDS5; -.
DR OpenTargets; ENSG00000162881; -.
DR PharmGKB; PA134983779; -.
DR VEuPathDB; HostDB:ENSG00000162881; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00990000203619; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q8TDS5; -.
DR OMA; FIFCVHT; -.
DR OrthoDB; 903658at2759; -.
DR PhylomeDB; Q8TDS5; -.
DR TreeFam; TF330775; -.
DR PathwayCommons; Q8TDS5; -.
DR Reactome; R-HSA-391903; Eicosanoid ligand-binding receptors.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; Q8TDS5; -.
DR SIGNOR; Q8TDS5; -.
DR BioGRID-ORCS; 165140; 14 hits in 1063 CRISPR screens.
DR GeneWiki; Oxoeicosanoid_receptor_1; -.
DR GenomeRNAi; 165140; -.
DR Pharos; Q8TDS5; Tchem.
DR PRO; PR:Q8TDS5; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8TDS5; protein.
DR Bgee; ENSG00000162881; Expressed in right lobe of liver and 95 other tissues.
DR Genevisible; Q8TDS5; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0050648; F:5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding; IDA:UniProtKB.
DR GO; GO:0050647; F:5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding; IDA:UniProtKB.
DR GO; GO:0050646; F:5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IMP:UniProtKB.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..423
FT /note="Oxoeicosanoid receptor 1"
FT /id="PRO_0000069993"
FT TOPO_DOM 1..97
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 119..126
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..168
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..191
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 192..211
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..254
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..295
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 296..316
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 317..336
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 337..357
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 358..423
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 165..237
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 316
FT /note="M -> L (in dbSNP:rs17029947)"
FT /id="VAR_049428"
FT VARIANT 407
FT /note="L -> V (in dbSNP:rs2278586)"
FT /evidence="ECO:0000269|PubMed:12606753"
FT /id="VAR_023940"
SQ SEQUENCE 423 AA; 45811 MW; 72ADA9F43A9EC051 CRC64;
MLCHRGGQLI VPIIPLCPEH SCRGRRLQNL LSGPWPKQPM ELHNLSSPSP SLSSSVLPPS
FSPSPSSAPS AFTTVGGSSG GPCHPTSSSL VSAFLAPILA LEFVLGLVGN SLALFIFCIH
TRPWTSNTVF LVSLVAADFL LISNLPLRVD YYLLHETWRF GAAACKVNLF MLSTNRTASV
VFLTAIALNR YLKVVQPHHV LSRASVGAAA RVAGGLWVGI LLLNGHLLLS TFSGPSCLSY
RVGTKPSASL RWHQALYLLE FFLPLALILF AIVSIGLTIR NRGLGGQAGP QRAMRVLAMV
VAVYTICFLP SIIFGMASMV AFWLSACRSL DLCTQLFHGS LAFTYLNSVL DPVLYCFSSP
NFLHQSRALL GLTRGRQGPV SDESSYQPSR QWRYREASRK AEAIGKLKVQ GEVSLEKEGS
SQG
