OXGR1_HUMAN
ID OXGR1_HUMAN Reviewed; 337 AA.
AC Q96P68; Q5T5A7; Q86TL1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=2-oxoglutarate receptor 1;
DE AltName: Full=Alpha-ketoglutarate receptor 1;
DE AltName: Full=G-protein coupled receptor 80;
DE AltName: Full=G-protein coupled receptor 99;
DE AltName: Full=P2Y purinoceptor 15;
DE Short=P2Y15;
DE AltName: Full=P2Y-like GPCR;
DE AltName: Full=P2Y-like nucleotide receptor;
GN Name=OXGR1; Synonyms=GPR80, GPR99, P2RY15, P2Y15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11574155; DOI=10.1016/s0378-1119(01)00651-5;
RA Lee D.K., Nguyen T., Lynch K.R., Cheng R., Vanti W.B., Arkhitko O.,
RA Lewis T., Evans J.F., George S.R., O'Dowd B.F.;
RT "Discovery and mapping of ten novel G protein-coupled receptor genes.";
RL Gene 275:83-91(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=12098360; DOI=10.1186/1471-2164-3-17;
RA Wittenberger T., Hellebrand S., Munck A., Kreienkamp H.-J., Schaller H.C.,
RA Hampe W.;
RT "GPR99, a new G protein-coupled receptor with homology to a new subgroup of
RT nucleotide receptors.";
RL BMC Genomics 3:17-17(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12044878; DOI=10.1016/s0014-5793(02)02775-8;
RA Takeda S., Kadowaki S., Haga T., Takaesu H., Mitaku S.;
RT "Identification of G protein-coupled receptor genes from the human genome
RT sequence.";
RL FEBS Lett. 520:97-101(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Thyroid;
RA Bruess M., Bonisch H., von Kugelgen I.;
RT "Molecular cloning and functional characterization of a new human P2Y
RT receptor.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Receptor for alpha-ketoglutarate. Seems to act exclusively
CC through a G(q)-mediated pathway (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Detected in kidney and, to a lower extent, in
CC placenta. Not detected in brain tissues including the frontal cortex,
CC caudate putamen, thalamus, hypothalamus, hippocampus or pons.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Was originally (Ref.5) thought to be a P2Y receptor.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF411109; AAL26480.1; -; Genomic_DNA.
DR EMBL; AF370886; AAM76912.1; -; mRNA.
DR EMBL; AB083598; BAB89311.1; -; Genomic_DNA.
DR EMBL; AB065877; BAC06095.1; -; Genomic_DNA.
DR EMBL; AJ305372; CAC83857.1; -; mRNA.
DR EMBL; AL356486; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC103881; AAI03882.1; -; mRNA.
DR EMBL; BC103882; AAI03883.1; -; mRNA.
DR EMBL; BC103883; AAI03884.1; -; mRNA.
DR CCDS; CCDS9482.1; -.
DR RefSeq; NP_001333123.1; NM_001346194.1.
DR RefSeq; NP_001333124.1; NM_001346195.1.
DR RefSeq; NP_001333125.1; NM_001346196.1.
DR RefSeq; NP_001333126.1; NM_001346197.1.
DR RefSeq; NP_543008.3; NM_080818.4.
DR RefSeq; XP_005254100.1; XM_005254043.3.
DR RefSeq; XP_005254101.1; XM_005254044.3.
DR RefSeq; XP_005254102.1; XM_005254045.2.
DR RefSeq; XP_005254103.1; XM_005254046.2.
DR RefSeq; XP_011519379.1; XM_011521077.2.
DR AlphaFoldDB; Q96P68; -.
DR SMR; Q96P68; -.
DR BioGRID; 118074; 1.
DR STRING; 9606.ENSP00000298440; -.
DR BindingDB; Q96P68; -.
DR ChEMBL; CHEMBL2150840; -.
DR GuidetoPHARMACOLOGY; 162; -.
DR GlyGen; Q96P68; 4 sites.
DR iPTMnet; Q96P68; -.
DR PhosphoSitePlus; Q96P68; -.
DR BioMuta; OXGR1; -.
DR DMDM; 48474598; -.
DR PaxDb; Q96P68; -.
DR PeptideAtlas; Q96P68; -.
DR PRIDE; Q96P68; -.
DR Antibodypedia; 10650; 122 antibodies from 26 providers.
DR DNASU; 27199; -.
DR Ensembl; ENST00000298440.5; ENSP00000298440.1; ENSG00000165621.9.
DR Ensembl; ENST00000541038.2; ENSP00000437356.2; ENSG00000165621.9.
DR Ensembl; ENST00000541518.6; ENSP00000445269.2; ENSG00000165621.9.
DR Ensembl; ENST00000543457.6; ENSP00000438800.1; ENSG00000165621.9.
DR GeneID; 27199; -.
DR KEGG; hsa:27199; -.
DR MANE-Select; ENST00000541038.2; ENSP00000437356.2; NM_001346194.2; NP_001333123.1.
DR UCSC; uc001vmx.1; human.
DR CTD; 27199; -.
DR DisGeNET; 27199; -.
DR GeneCards; OXGR1; -.
DR HGNC; HGNC:4531; OXGR1.
DR HPA; ENSG00000165621; Low tissue specificity.
DR MIM; 606922; gene.
DR neXtProt; NX_Q96P68; -.
DR OpenTargets; ENSG00000165621; -.
DR PharmGKB; PA28924; -.
DR VEuPathDB; HostDB:ENSG00000165621; -.
DR eggNOG; ENOG502QYYG; Eukaryota.
DR GeneTree; ENSGT01030000234621; -.
DR HOGENOM; CLU_009579_8_2_1; -.
DR InParanoid; Q96P68; -.
DR OMA; FVIIHPM; -.
DR OrthoDB; 933668at2759; -.
DR PhylomeDB; Q96P68; -.
DR TreeFam; TF330775; -.
DR PathwayCommons; Q96P68; -.
DR Reactome; R-HSA-373076; Class A/1 (Rhodopsin-like receptors).
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR SignaLink; Q96P68; -.
DR SIGNOR; Q96P68; -.
DR BioGRID-ORCS; 27199; 7 hits in 1063 CRISPR screens.
DR GeneWiki; OXGR1; -.
DR GenomeRNAi; 27199; -.
DR Pharos; Q96P68; Tchem.
DR PRO; PR:Q96P68; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q96P68; protein.
DR Bgee; ENSG00000165621; Expressed in islet of Langerhans and 91 other tissues.
DR ExpressionAtlas; Q96P68; baseline and differential.
DR Genevisible; Q96P68; HS.
DR GO; GO:0016021; C:integral component of membrane; TAS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..337
FT /note="2-oxoglutarate receptor 1"
FT /id="PRO_0000069994"
FT TOPO_DOM 1..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..116
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 117..137
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 138..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..201
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..242
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..263
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 264..284
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..337
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 23
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 176
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 106..183
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 14
FT /note="F -> L (in Ref. 5; CAC83857)"
FT /evidence="ECO:0000305"
FT CONFLICT 236
FT /note="K -> R (in Ref. 5; CAC83857)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 337 AA; 38251 MW; 6814EA0044756CE6 CRC64;
MNEPLDYLAN ASDFPDYAAA FGNCTDENIP LKMHYLPVIY GIIFLVGFPG NAVVISTYIF
KMRPWKSSTI IMLNLACTDL LYLTSLPFLI HYYASGENWI FGDFMCKFIR FSFHFNLYSS
ILFLTCFSIF RYCVIIHPMS CFSIHKTRCA VVACAVVWII SLVAVIPMTF LITSTNRTNR
SACLDLTSSD ELNTIKWYNL ILTATTFCLP LVIVTLCYTT IIHTLTHGLQ TDSCLKQKAR
RLTILLLLAF YVCFLPFHIL RVIRIESRLL SISCSIENQI HEAYIVSRPL AALNTFGNLL
LYVVVSDNFQ QAVCSTVRCK VSGNLEQAKK ISYSNNP
