ID   OXIR_STRAT              Reviewed;         298 AA.
AC   Q03326;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Probable oxidoreductase;
DE            EC=1.-.-.-;
OS   Streptomyces antibioticus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1890;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 41481 / IMRU 3720;
RX   PubMed=8383668; DOI=10.1128/jb.175.6.1847-1852.1993;
RA   Yu T.-W., Chen C.W.;
RT   "The unstable melC operon of Streptomyces antibioticus is codeleted with a
RT   Tn4811-homologous locus.";
RL   J. Bacteriol. 175:1847-1852(1993).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; M96551; AAA26796.1; -; Genomic_DNA.
DR   PIR; A47089; A47089.
DR   AlphaFoldDB; Q03326; -.
DR   SMR; Q03326; -.
DR   STRING; 1890.AFM16_00350; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..298
FT                   /note="Probable oxidoreductase"
FT                   /id="PRO_0000054737"
FT   ACT_SITE        165
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         9..33
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         139
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   298 AA;  31415 MW;  DD24DD156632E10C CRC64;
     MDLTGRRAVV TGGASGLGAE TVRALAAAGA EVTVATRRPL SAEPLVQELA AAGGAGRVTA
     EALDLSDPAS VESFARAWRG PLDILVANAG IMALPTRTLA PNGWEMQLAT NYLGHFALAT
     GLHAALRDAG SARIVVVSSG AHLDAPFDFE DAHFARRPYD PWVAYGQSKA ADVLFTVGAR
     RWAADGITVN ALNPGYILTR LQRHVDDETM RAFGVMDDQG NVKPLPYYKT PEQGAATSVL
     LAASPLLKGV TGRYFEDNQE ARTVQGQEDQ PGGVAAHALD PEAADRLWEY GTDALRAA