OXND1_MOUSE
ID OXND1_MOUSE Reviewed; 311 AA.
AC Q8VE38; Q3UT09; Q8C093;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Oxidoreductase NAD-binding domain-containing protein 1;
DE EC=1.-.-.-;
DE Flags: Precursor;
GN Name=Oxnad1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Egg, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=Czech II;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8VE38-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8VE38-2; Sequence=VSP_027765;
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DR EMBL; AK031978; BAC27636.1; -; mRNA.
DR EMBL; AK139884; BAE24171.1; -; mRNA.
DR EMBL; BC019806; AAH19806.1; -; mRNA.
DR CCDS; CCDS26918.1; -. [Q8VE38-1]
DR RefSeq; NP_663435.2; NM_145460.2. [Q8VE38-1]
DR AlphaFoldDB; Q8VE38; -.
DR SMR; Q8VE38; -.
DR BioGRID; 230076; 22.
DR IntAct; Q8VE38; 20.
DR STRING; 10090.ENSMUSP00000022462; -.
DR iPTMnet; Q8VE38; -.
DR PhosphoSitePlus; Q8VE38; -.
DR EPD; Q8VE38; -.
DR MaxQB; Q8VE38; -.
DR PaxDb; Q8VE38; -.
DR PeptideAtlas; Q8VE38; -.
DR PRIDE; Q8VE38; -.
DR ProteomicsDB; 295495; -. [Q8VE38-1]
DR ProteomicsDB; 295496; -. [Q8VE38-2]
DR Antibodypedia; 53314; 139 antibodies from 20 providers.
DR DNASU; 218885; -.
DR Ensembl; ENSMUST00000022462; ENSMUSP00000022462; ENSMUSG00000021906. [Q8VE38-1]
DR GeneID; 218885; -.
DR KEGG; mmu:218885; -.
DR UCSC; uc007syg.2; mouse. [Q8VE38-1]
DR CTD; 92106; -.
DR MGI; MGI:1916953; Oxnad1.
DR VEuPathDB; HostDB:ENSMUSG00000021906; -.
DR eggNOG; KOG0534; Eukaryota.
DR GeneTree; ENSGT00390000004280; -.
DR HOGENOM; CLU_003827_7_1_1; -.
DR InParanoid; Q8VE38; -.
DR OMA; WIDFFIP; -.
DR OrthoDB; 696109at2759; -.
DR PhylomeDB; Q8VE38; -.
DR TreeFam; TF329774; -.
DR BioGRID-ORCS; 218885; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Oxnad1; mouse.
DR PRO; PR:Q8VE38; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q8VE38; protein.
DR Bgee; ENSMUSG00000021906; Expressed in heart right ventricle and 257 other tissues.
DR ExpressionAtlas; Q8VE38; baseline and differential.
DR Genevisible; Q8VE38; MM.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.80; -; 1.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR Pfam; PF00175; NAD_binding_1; 1.
DR SUPFAM; SSF52343; SSF52343; 1.
DR SUPFAM; SSF63380; SSF63380; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; NAD; Oxidoreductase; Reference proteome; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..311
FT /note="Oxidoreductase NAD-binding domain-containing protein
FT 1"
FT /id="PRO_0000299572"
FT DOMAIN 60..171
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00716"
FT BINDING 177..182
FT /ligand="NAD(+)"
FT /ligand_id="ChEBI:CHEBI:57540"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..61
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027765"
FT CONFLICT 202..203
FT /note="RS -> SG (in Ref. 2; AAH19806)"
FT /evidence="ECO:0000305"
FT CONFLICT 253
FT /note="A -> V (in Ref. 2; AAH19806)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 311 AA; 34727 MW; 7F8B5A18C32FD33E CRC64;
MAHVALIPGL SRGSVGAVCT QAASWGLKAS TLRHLTLASI IKSRRKTDHL ERTASVLRRE
VMAAAKVCEI THESPSVKSL RLLVADKDFS FKAGQWVDFF IPGVSVVGGF SICSSPQRLE
RDRIIELAVK YADHPPAVWV HNKCTLDSEV ALRVGGEFFF DPQPTDAPRN LILIAGGVGI
NPLLSILRHS ADLHRDHADK GRSYEIGTVK LFYSAKNTSE LLFKKDILDL VHEFPEKISC
SFHVTKQTAQ ISAELKPYVT DGRITEKEIR DHISAETLFY VCGPPPMTDF FSKHLESCHV
PKEHICFEKW W
