OXR1_CANAL
ID OXR1_CANAL Reviewed; 345 AA.
AC Q5AEM5; A0A1D8PJJ3; Q5AF12;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 2.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Oxidation resistance protein 1;
GN Name=OXR1; OrderedLocusNames=CAALFM_C302540CA;
GN ORFNames=CaO19.243, CaO19.7873;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: May be involved in protection from oxidative damage.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the OXR1 family. {ECO:0000305}.
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DR EMBL; CP017625; AOW28288.1; -; Genomic_DNA.
DR RefSeq; XP_719942.2; XM_714849.2.
DR AlphaFoldDB; Q5AEM5; -.
DR SMR; Q5AEM5; -.
DR STRING; 237561.Q5AEM5; -.
DR PRIDE; Q5AEM5; -.
DR GeneID; 3638372; -.
DR KEGG; cal:CAALFM_C302540CA; -.
DR CGD; CAL0000197295; OXR1.
DR VEuPathDB; FungiDB:C3_02540C_A; -.
DR eggNOG; KOG2372; Eukaryota.
DR HOGENOM; CLU_029204_0_0_1; -.
DR InParanoid; Q5AEM5; -.
DR OrthoDB; 1133465at2759; -.
DR PRO; PR:Q5AEM5; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR InterPro; IPR006571; TLDc_dom.
DR Pfam; PF07534; TLD; 1.
DR SMART; SM00584; TLDc; 1.
DR PROSITE; PS51886; TLDC; 1.
PE 3: Inferred from homology;
KW Mitochondrion; Reference proteome.
FT CHAIN 1..345
FT /note="Oxidation resistance protein 1"
FT /id="PRO_0000058111"
FT DOMAIN 114..342
FT /note="TLDc"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..98
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 39398 MW; 6429DD0BE5228919 CRC64;
MSFLFRRSIE QPRVNEKETN KEVKDEPQHQ QQEKEDDNSK QEELLSDSVN EKPKEQPKPV
KRRGTFFGNL LGNGSKNSSS ASLNSSHSSV SSSSKFPPLG PLTLTGYKES THHRLLDSEL
ANNIRNLIPA RFQLFDNWEL VYSLEQHGIS LNTLYRNSNP EHQLRLLKKQ KAAEKGFADS
IVKNMVVGDT SRPRYSFEPK RSQSYVLVIK DNHNNKFGAY LSENLKPMEH RRYYGNGECF
LWKCEKYDPS KLDHAVDKRA TQEIRFKAFM YTGINDNIIY SNHDFIAIGS SNGQNGLFID
KSLLSGVSYS CDTFGNEILN SSPQNAKFGS FKIKGLEVWR IGTLE