ID   OXR1_CRYNB              Reviewed;         465 AA.
AC   P0CP43; Q55R20; Q5KF46;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Oxidation resistance protein 1;
GN   Name=OXR1; OrderedLocusNames=CNBF1690;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: May be involved in protection from oxidative damage.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXR1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAEY01000030; EAL20359.1; -; Genomic_DNA.
DR   RefSeq; XP_775006.1; XM_769913.1.
DR   AlphaFoldDB; P0CP43; -.
DR   SMR; P0CP43; -.
DR   EnsemblFungi; EAL20359; EAL20359; CNBF1690.
DR   GeneID; 4936721; -.
DR   KEGG; cnb:CNBF1690; -.
DR   VEuPathDB; FungiDB:CNBF1690; -.
DR   HOGENOM; CLU_593145_0_0_1; -.
DR   Proteomes; UP000001435; Chromosome 6.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006571; TLDc_dom.
DR   Pfam; PF07534; TLD; 1.
DR   SMART; SM00584; TLDc; 1.
DR   PROSITE; PS51886; TLDC; 1.
PE   3: Inferred from homology;
KW   Mitochondrion.
FT   CHAIN           1..465
FT                   /note="Oxidation resistance protein 1"
FT                   /id="PRO_0000410179"
FT   DOMAIN          287..465
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          73..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          144..183
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..119
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..164
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..183
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..222
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   465 AA;  50814 MW;  EA95E43F6FBC9FE6 CRC64;
     MPHHHSLPTS SADFGDFNSA PASSIQTSSL SQDDLLGSYD ETIRHSPSVK SHPSPDPRAS
     NLDLLFLDHN AEEHRRPEPT YSPRSRPTGV LPESVPHARS PRRLSTFSSS TSPTSPPSIT
     DAGCDIIFHP FYDHMDVNAT RAMQKMQGHG ERGASKRSDK MQLRGQASHS RIAPSSSPPH
     SRLLDTLATT TKLASKWRSV IAHPTSPNTA DQTHNGQPKP QIRHAETSPM DITHDTPFAS
     AEQIAGSYIP PTGAPGFTQA SVLGMKHHGD GPFEPLTLIG RKDSTSNVLT PEDAIGLKAC
     LPPRQRLTNQ WTLLFSLDQH GASLSTLYRL IDIYSVSHQS SGNILVIRDG HGNRFGTYMN
     EPIVKREGTY YGSGESFLFK LTHSCQTIPY RWTGKNKYFA LCEAGFMSFG GGAGAYGLIL
     DSTFTHNSSA TCPAYNNDIL CELEPLKSQH AQSFQCLGLE VWSTL