ID   OXR1_NEUCR              Reviewed;         389 AA.
AC   Q7S4P1;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Oxidation resistance protein 1;
GN   Name=oxr1; ORFNames=NCU02394;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: May be involved in protection from oxidative damage.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OXR1 family. {ECO:0000305}.
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DR   EMBL; CM002242; EAA30478.2; -; Genomic_DNA.
DR   RefSeq; XP_959714.2; XM_954621.2.
DR   AlphaFoldDB; Q7S4P1; -.
DR   SMR; Q7S4P1; -.
DR   STRING; 5141.EFNCRP00000003218; -.
DR   EnsemblFungi; EAA30478; EAA30478; NCU02394.
DR   GeneID; 3875861; -.
DR   KEGG; ncr:NCU02394; -.
DR   VEuPathDB; FungiDB:NCU02394; -.
DR   HOGENOM; CLU_029204_0_1_1; -.
DR   InParanoid; Q7S4P1; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR   InterPro; IPR006571; TLDc_dom.
DR   Pfam; PF07534; TLD; 2.
DR   SMART; SM00584; TLDc; 1.
DR   PROSITE; PS51886; TLDC; 1.
PE   3: Inferred from homology;
KW   Mitochondrion; Reference proteome.
FT   CHAIN           1..389
FT                   /note="Oxidation resistance protein 1"
FT                   /id="PRO_0000058118"
FT   DOMAIN          138..385
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          238..269
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   389 AA;  41720 MW;  E7F601DE471E70BE CRC64;
     MSYHDARRRH PHPIQTFRPE SEYSSSAPGS GAQTPTGSGA SSSQLPGLVS SIWGGLIRRF
     SAETPSLTHS QSYPADSSHS HFDDHNYNNS NDNNGVDGVY VPPRFHETIQ RTASPMQPPP
     LEPVQLKGFA PDTPASARIL TQAIAEEIRI MVPTRLSIVD EWNLVYSLDQ DGASLGTLYD
     KCAKYSGRRV GFVLVVKDAE GGIFGAYLSD FPHPAPKYFG TGECFLWRAS VMASLPPPPS
     ADTTNLRGRT STISSVGTGT DTATNTATNH NSGDDLASCT VLRATTTATP PHNDSADDLF
     ADLTGTVDQT TIRFKAFPYS GVNDYYILCE SHFLSVGAGD GKFGLWLDDG LEKGVSSTSQ
     TFGNEQLSDQ GEKFSVLGVE VWVIGSGGL