OXR1_RAT
ID OXR1_RAT Reviewed; 839 AA.
AC Q4V8B0; B2RYF9; Q99MK0;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 3.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Oxidation resistance protein 1;
DE AltName: Full=Protein C7;
GN Name=Oxr1; Synonyms=C7;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RX PubMed=11237729; DOI=10.1006/bbrc.2001.4345;
RA Fischer H., Zhang X.U., O'Brien K.P., Kylsten P., Engvall E.;
RT "C7, a novel nucleolar protein, is the mouse homologue of the Drosophila
RT late puff product L82 and an isoform of human OXR1.";
RL Biochem. Biophys. Res. Commun. 281:795-803(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Prostate, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194; SER-195; SER-197;
RP SER-327; SER-329; SER-339 AND SER-488, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- FUNCTION: May be involved in protection from oxidative damage.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q4V8B0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4V8B0-2; Sequence=VSP_017870, VSP_017871;
CC Name=3; Synonyms=C7C;
CC IsoId=Q4V8B0-3; Sequence=VSP_017869, VSP_017872;
CC -!- SIMILARITY: Belongs to the OXR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI66763.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF333986; AAK29401.1; -; mRNA.
DR EMBL; AABR03055922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03056092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03059133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AABR03060217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC081744; AAH81744.1; -; mRNA.
DR EMBL; BC097465; AAH97465.1; -; mRNA.
DR EMBL; BC166763; AAI66763.1; ALT_INIT; mRNA.
DR RefSeq; NP_001184261.1; NM_001197332.1. [Q4V8B0-3]
DR RefSeq; NP_476494.2; NM_057153.3.
DR RefSeq; XP_017450109.1; XM_017594620.1.
DR AlphaFoldDB; Q4V8B0; -.
DR SMR; Q4V8B0; -.
DR STRING; 10116.ENSRNOP00000010856; -.
DR iPTMnet; Q4V8B0; -.
DR PhosphoSitePlus; Q4V8B0; -.
DR PaxDb; Q4V8B0; -.
DR PRIDE; Q4V8B0; -.
DR GeneID; 117520; -.
DR KEGG; rno:117520; -.
DR UCSC; RGD:621857; rat. [Q4V8B0-1]
DR CTD; 55074; -.
DR RGD; 621857; Oxr1.
DR eggNOG; KOG2372; Eukaryota.
DR InParanoid; Q4V8B0; -.
DR OrthoDB; 767847at2759; -.
DR PhylomeDB; Q4V8B0; -.
DR PRO; PR:Q4V8B0; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000056487; Expressed in cerebellum and 19 other tissues.
DR ExpressionAtlas; Q4V8B0; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IDA:RGD.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016491; F:oxidoreductase activity; ISO:RGD.
DR GO; GO:0007628; P:adult walking behavior; ISO:RGD.
DR GO; GO:0071447; P:cellular response to hydroperoxide; ISO:RGD.
DR GO; GO:1900408; P:negative regulation of cellular response to oxidative stress; ISO:RGD.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISO:RGD.
DR GO; GO:1903204; P:negative regulation of oxidative stress-induced neuron death; ISO:RGD.
DR GO; GO:1902083; P:negative regulation of peptidyl-cysteine S-nitrosylation; ISO:RGD.
DR GO; GO:0051402; P:neuron apoptotic process; ISO:RGD.
DR GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR CDD; cd00118; LysM; 1.
DR Gene3D; 3.10.350.10; -; 1.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR InterPro; IPR006571; TLDc_dom.
DR Pfam; PF01476; LysM; 1.
DR Pfam; PF07534; TLD; 1.
DR SMART; SM00257; LysM; 1.
DR SMART; SM00584; TLDc; 1.
DR SUPFAM; SSF54106; SSF54106; 1.
DR PROSITE; PS51782; LYSM; 1.
DR PROSITE; PS51886; TLDC; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Mitochondrion; Phosphoprotein; Reference proteome.
FT CHAIN 1..839
FT /note="Oxidation resistance protein 1"
FT /id="PRO_0000231647"
FT DOMAIN 91..134
FT /note="LysM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
FT DOMAIN 206..261
FT /note="GRAM"
FT DOMAIN 678..839
FT /note="TLDc"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT REGION 38..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..570
FT /note="Mediates oxidative antimutator activity"
FT /evidence="ECO:0000250"
FT REGION 648..677
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..85
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..501
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 517..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 83
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N573"
FT MOD_RES 111
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q4KMM3"
FT MOD_RES 194
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 195
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 197
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 287
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8N573"
FT MOD_RES 327
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 329
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 334
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q4KMM3"
FT MOD_RES 339
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 488
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT VAR_SEQ 1..623
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11237729,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_017869"
FT VAR_SEQ 1..510
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_017870"
FT VAR_SEQ 511..645
FT /note="RDTIQQVAQRESKHRGAPADAHGEGSSLLKEKRRHRLHKFLCLRVGKPMRKT
FT FVSQASATMQQYAQRDKKHEYWFAVPQERTDHLYAFFIQWSPEIYAEDTGEYTREPGFI
FT VVKKMAESGPDEAPAGEAAAREWE -> MEKAYTLIVFFLLLRLSFILCGFPEATCFWR
FT INHNEHLESNMRKDCGFILFTIPVHLVEDHFRVLLDFPFPLRCAVCLAILVSRNRILKE
FT KQTAVLIVSDVLPMRFPTPQVVSVAEYHRRIDALNTEELRTLCRRLQ (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_017871"
FT VAR_SEQ 624..645
FT /note="KKMAESGPDEAPAGEAAAREWE -> MSRLWYGKKGRRHQQVNHKYTL (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:11237729,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_017872"
SQ SEQUENCE 839 AA; 92810 MW; 0CC16D2DBDE2FB02 CRC64;
MDYLTTFTGK SGRLLRGTAS RLWGLGGGGE ARQVRFEDYL REPAPGDPGC GPGELRPPSP
TSPEGPDTGQ KKTLDKKDGR RMSFQKPKGT IEYTVESRDS LNSIALKFDT TPNELVQLNK
LFSRAVVTGQ VLYVPDPEYV SSVESSPSLS PVSPLSPTSS EAEFDKTTTP DVVHPKEAPP
SSTESSIRPA RVVSSTSEEE EAFTEKFLKI NCKYITNGKG TVSGVLLVTP NNIMFDPHKT
DPLVQENGCE EYGIMCPMEE VMSAAMYKEI LDSKLKESLP IEVDQLSGRG FCHSKKMTGV
PAEETDSRSR DQGNDSVSTA PRSTEESLSE DVFTESELSP IREELPSSEL RQEKSSDASS
ESVQTVSQIE VESLTAASES ADVPDHTNAN SGRSSSEVGA LSHETGLSSL EIATKEGDKA
TGNLQEVSGP KEQSTDIKGQ DNQDSFHHEN SLQQEAGEDS LSSGETVELT EKPTVLKDQQ
GKELKRDSET EVEELRKLWK THSMQQAKQQ RDTIQQVAQR ESKHRGAPAD AHGEGSSLLK
EKRRHRLHKF LCLRVGKPMR KTFVSQASAT MQQYAQRDKK HEYWFAVPQE RTDHLYAFFI
QWSPEIYAED TGEYTREPGF IVVKKMAESG PDEAPAGEAA AREWEITTRE DINSKQAAPA
KADLEPESFR PNLSDPSELL LPDQIEKLTK HLPPRTIGYP WTLVYGTGKH GTSLKTLYRT
MTGLDTPVLM VIKDSDGQVF GALASEPFKV SDGFYGTGET FVFTFCPEFE VFKWTGDNMF
FIKGDMDSLA FGGGGGEFAL WLDGDLYHGR SHSCKTFGNH TLSKKEDFFI QDIEIWAFE
