ID   OXR1_SCHPO              Reviewed;         188 AA.
AC   O14284;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Oxidation resistance protein 1;
DE   AltName: Full=Meiotically up-regulated gene 63 protein;
GN   Name=oxr1; Synonyms=mug63; ORFNames=SPAC8C9.16c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION IN MEIOSIS.
RX   PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA   Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA   Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA   Smith G.R., Moreno S.;
RT   "A large-scale screen in S. pombe identifies seven novel genes required for
RT   critical meiotic events.";
RL   Curr. Biol. 15:2056-2062(2005).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: May be involved in protection from oxidative damage (By
CC       similarity). Has a role in meiosis. {ECO:0000250,
CC       ECO:0000269|PubMed:16303567}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Cytoplasm
CC       {ECO:0000269|PubMed:16823372}. Nucleus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the OXR1 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB16303.1; -; Genomic_DNA.
DR   PIR; T39152; T39152.
DR   RefSeq; NP_594286.1; NM_001019709.2.
DR   AlphaFoldDB; O14284; -.
DR   SMR; O14284; -.
DR   BioGRID; 278425; 16.
DR   STRING; 4896.SPAC8C9.16c.1; -.
DR   MaxQB; O14284; -.
DR   PaxDb; O14284; -.
DR   EnsemblFungi; SPAC8C9.16c.1; SPAC8C9.16c.1:pep; SPAC8C9.16c.
DR   GeneID; 2541938; -.
DR   KEGG; spo:SPAC8C9.16c; -.
DR   PomBase; SPAC8C9.16c; -.
DR   VEuPathDB; FungiDB:SPAC8C9.16c; -.
DR   eggNOG; KOG2372; Eukaryota.
DR   HOGENOM; CLU_029204_0_0_1; -.
DR   InParanoid; O14284; -.
DR   OMA; YRGGSHP; -.
DR   PhylomeDB; O14284; -.
DR   PRO; PR:O14284; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0033176; C:proton-transporting V-type ATPase complex; ISO:PomBase.
DR   GO; GO:0042030; F:ATPase inhibitor activity; ISO:PomBase.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0030641; P:regulation of cellular pH; ISO:PomBase.
DR   GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR   InterPro; IPR006571; TLDc_dom.
DR   Pfam; PF07534; TLD; 1.
DR   SMART; SM00584; TLDc; 1.
DR   PROSITE; PS51886; TLDC; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Meiosis; Mitochondrion; Nucleus; Reference proteome.
FT   CHAIN           1..188
FT                   /note="Oxidation resistance protein 1"
FT                   /id="PRO_0000058121"
FT   DOMAIN          13..188
FT                   /note="TLDc"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
SQ   SEQUENCE   188 AA;  21454 MW;  7060E84834E26900 CRC64;
     MFNFTRQYSV KDGLITDELA SHIVENLPAR YASAETWKRI YSLQHDGASL QTMYLACEKE
     KARSGHPKGA CILAVRDTDG DVFGVFIPDY LIPAPHYFGS EETFLWKYFP PKKYVHYPFV
     GNSNFVAYCT KSFLAFGGGN GRYSLWLDGS LEYAYSSRTP AFENNPLSYR GCPDQRIQIV
     DIELWVLE