OXR1_XENTR
ID OXR1_XENTR Reviewed; 870 AA.
AC A8KBE0; B0JZG8;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 2.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Oxidation resistance protein 1;
GN Name=oxr1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in protection from oxidative damage.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A8KBE0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A8KBE0-2; Sequence=VSP_039017, VSP_039018;
CC -!- SIMILARITY: Belongs to the OXR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI54077.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI59173.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC154076; AAI54077.1; ALT_INIT; mRNA.
DR EMBL; BC159172; AAI59173.1; ALT_INIT; mRNA.
DR RefSeq; NP_001106462.1; NM_001112991.1.
DR RefSeq; XP_012819675.1; XM_012964221.1.
DR RefSeq; XP_012819676.1; XM_012964222.1.
DR RefSeq; XP_012819680.1; XM_012964226.2.
DR RefSeq; XP_017950011.1; XM_018094522.1.
DR AlphaFoldDB; A8KBE0; -.
DR SMR; A8KBE0; -.
DR STRING; 8364.ENSXETP00000014232; -.
DR PaxDb; A8KBE0; -.
DR DNASU; 100127645; -.
DR GeneID; 100127645; -.
DR KEGG; xtr:100127645; -.
DR CTD; 55074; -.
DR Xenbase; XB-GENE-980206; oxr1.
DR eggNOG; KOG2372; Eukaryota.
DR InParanoid; A8KBE0; -.
DR OrthoDB; 767847at2759; -.
DR Proteomes; UP000008143; Chromosome 6.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR CDD; cd00118; LysM; 1.
DR Gene3D; 3.10.350.10; -; 1.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR InterPro; IPR006571; TLDc_dom.
DR Pfam; PF01476; LysM; 1.
DR Pfam; PF07534; TLD; 1.
DR SMART; SM00257; LysM; 1.
DR SMART; SM00584; TLDc; 1.
DR SUPFAM; SSF54106; SSF54106; 1.
DR PROSITE; PS51782; LYSM; 1.
DR PROSITE; PS51886; TLDC; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Mitochondrion; Reference proteome; Stress response.
FT CHAIN 1..870
FT /note="Oxidation resistance protein 1"
FT /id="PRO_0000393588"
FT DOMAIN 95..138
FT /note="LysM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
FT DOMAIN 209..267
FT /note="GRAM"
FT DOMAIN 709..870
FT /note="TLDc"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT REGION 45..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..708
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..361
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..70
FT /note="MFSTRRLKKKSQSVDIAASGYNPLSDASAPQASRVPPPIVKAISEEEHHNTT
FT NAQKRHLRRGDLKRGYTI -> MDYLTDFTGRSGRVLRGTVNRLWYGHREVRFQDCLKD
FT VHRESMARPPQLLSS (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_039017"
FT VAR_SEQ 650..676
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_039018"
SQ SEQUENCE 870 AA; 97718 MW; 08DCBBFE635F7B08 CRC64;
MFSTRRLKKK SQSVDIAASG YNPLSDASAP QASRVPPPIV KAISEEEHHN TTNAQKRHLR
RGDLKRGYTI DTGQKKTLEK KDGRRMSFQR PKGTMEYTVE TRDSLNSIAL KFDTTPNELV
QLNKLFSRAV VPGQLLYVPD PDYISSVESS PSLSPISPLS PTSSEAEFEK STDTERMPYK
EITSSPAYSA IRPSRVVSST SEEEEAFTEK FLKINCKYIT DGKGTVNGVL LVTPNNIMFD
PHKNDLLVQE KGCEEYGIMC PMEEVTSAAM YKEIVNSKLK DSVSVDVGQL SCMREFCHLK
KISPGNLHDI DSQMWDAGND SASTAPRSTE ESLSEDVFTE SELSPIREEH LSSDELRQDK
SSGASSESVQ TINQNITECS LNISDCVSAS DDVKDSLEPS GNDSGIVASI NDLEKSEASI
NAGEGVDKDI SESSLILTEA IEGHNSNDGI LSSNKDKQTG DQNHSREAAF VRNHQHETVQ
EEAVKQSFGD SETEAEELRK FWKDLTMQQA KQQREDMQHT TQKEIMGKMP TAETHIEGVC
SSVAKEKRRH RSHRYLCLRV GKPMRKTFVS QASASMQQYA QRDKLEYWFA VPHERSDHLY
SFFIQWSPEL YAEEVRESAR EPGFVVVKKN EETEGSDCST NDSAARLWEV VSVAEYHRRI
DALNTEELRT LCRRLKITTR EDVNSKQATN IKNDQEPESF RPNLSDPSSL LQTDQIEKLT
KHLPPRTIGY PWTLVYSTAK HGMSLKTLYR TMLGLDTPVL LVIKDSDAQI FGALASEPFK
ISDCFYGTGE TFLFTFCPDF EVFKWTGDNM FFIKGDMDSL AFGGGGGEFA LWLDGDLYHG
RSHTCKTFGN CILSKKEDFI VQDIEIWAFE
