OXS3_ARATH
ID OXS3_ARATH Reviewed; 172 AA.
AC Q9LVB9;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein OXIDATIVE STRESS 3 {ECO:0000303|PubMed:18980652};
DE Short=AtOXS3 {ECO:0000303|PubMed:18980652};
GN Name=OXS3 {ECO:0000303|PubMed:18980652};
GN OrderedLocusNames=At5g56550 {ECO:0000312|Araport:AT5G56550};
GN ORFNames=MKN22.7 {ECO:0000312|EMBL:BAA97181.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, MUTAGENESIS OF LYS-88; ARG-89; LEU-91;
RP SER-92; LYS-98; SER-99; SER-101 AND PHE-102, TISSUE SPECIFICITY, INDUCTION
RP BY LIGHT, SUBCELLULAR LOCATION, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Landsberg erecta, and cv. Wassilewskija;
RX PubMed=18980652; DOI=10.1111/j.1365-313x.2008.03717.x;
RA Blanvillain R., Kim J.H., Wu S., Lima A., Ow D.W.;
RT "OXIDATIVE STRESS 3 is a chromatin-associated factor involved in tolerance
RT to heavy metals and oxidative stress.";
RL Plant J. 57:654-665(2009).
RN [5]
RP INDUCTION BY WOUNDING.
RC STRAIN=cv. Columbia;
RX PubMed=22937923; DOI=10.1186/1471-2229-12-157;
RA Wang X., Culver J.N.;
RT "DNA binding specificity of ATAF2, a NAC domain transcription factor
RT targeted for degradation by tobacco mosaic virus.";
RL BMC Plant Biol. 12:157-157(2012).
RN [6]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH SOC1.
RC STRAIN=cv. Columbia, and cv. Wassilewskija-4;
RX PubMed=31540691; DOI=10.1016/j.bbrc.2019.08.154;
RA Liang M., Xiao S., Cai J., Ow D.W.;
RT "OXIDATIVE STRESS 3 regulates drought-induced flowering through APETALA
RT 1.";
RL Biochem. Biophys. Res. Commun. 519:585-590(2019).
CC -!- FUNCTION: Promotes the tolerance to a range of metals, including
CC cadmium (Cd), arsenic (As) and copper (Cu) and to oxidizing chemicals
CC (e.g. diamide and tert-butyl hydroperoxide (t-BOOH)) (PubMed:18980652).
CC May act as a chromatin remodeling factor for stress responses
CC (PubMed:18980652). Negative regulator of flowering, especially during
CC drought stress, probably to prevent precocious flower development and
CC subsequent low seed set (PubMed:31540691). Repress the AP1 promoter in
CC a SOC1-dependent manner (PubMed:31540691).
CC {ECO:0000269|PubMed:18980652, ECO:0000269|PubMed:31540691}.
CC -!- SUBUNIT: Interacts with SOC1 in the nucleus.
CC {ECO:0000269|PubMed:31540691}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768,
CC ECO:0000269|PubMed:18980652, ECO:0000269|PubMed:31540691}. Nucleus
CC speckle {ECO:0000269|PubMed:18980652}. Note=Observed in a subnuclear
CC speckling pattern, discrete parts of the chromatin of the nucleosome.
CC {ECO:0000269|PubMed:18980652}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in stems, shoots and leaves, and,
CC to a lower extent, in siliques and seedlings (PubMed:18980652). Barely
CC detectable in roots (PubMed:18980652). {ECO:0000269|PubMed:18980652}.
CC -!- INDUCTION: Lower levels in the dark than in white, red and far-red
CC light (PubMed:18980652). Induced by wounding in an ATAF2-dependent
CC manner (PubMed:22937923). {ECO:0000269|PubMed:18980652,
CC ECO:0000269|PubMed:22937923}.
CC -!- DISRUPTION PHENOTYPE: Abolished ability to confer tolerance to stress
CC (e.g. metals and oxidizing chemicals such as Cd, As, Cu, diamide or
CC tert-butyl hydroperoxide (t-BOOH)) (PubMed:18980652). Early flowering
CC under mild drought stress treatment (PubMed:31540691).
CC {ECO:0000269|PubMed:18980652, ECO:0000269|PubMed:31540691}.
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DR EMBL; AB019234; BAA97181.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96780.1; -; Genomic_DNA.
DR EMBL; AK175485; BAD43248.1; -; mRNA.
DR EMBL; AK176596; BAD44359.1; -; mRNA.
DR RefSeq; NP_200466.1; NM_125038.6.
DR AlphaFoldDB; Q9LVB9; -.
DR STRING; 3702.AT5G56550.1; -.
DR PaxDb; Q9LVB9; -.
DR PRIDE; Q9LVB9; -.
DR EnsemblPlants; AT5G56550.1; AT5G56550.1; AT5G56550.
DR GeneID; 835756; -.
DR Gramene; AT5G56550.1; AT5G56550.1; AT5G56550.
DR KEGG; ath:AT5G56550; -.
DR Araport; AT5G56550; -.
DR TAIR; locus:2167101; AT5G56550.
DR eggNOG; KOG4210; Eukaryota.
DR HOGENOM; CLU_082868_2_1_1; -.
DR InParanoid; Q9LVB9; -.
DR OMA; WVIKEDD; -.
DR OrthoDB; 1496243at2759; -.
DR PhylomeDB; Q9LVB9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LVB9; baseline and differential.
DR GO; GO:0016607; C:nuclear speck; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:2000028; P:regulation of photoperiodism, flowering; IMP:UniProtKB.
DR GO; GO:2000070; P:regulation of response to water deprivation; IMP:UniProtKB.
DR GO; GO:0046686; P:response to cadmium ion; IMP:TAIR.
DR GO; GO:0046688; P:response to copper ion; IMP:UniProtKB.
DR GO; GO:0010218; P:response to far red light; IEP:UniProtKB.
DR GO; GO:0009416; P:response to light stimulus; IEP:UniProtKB.
DR GO; GO:0006979; P:response to oxidative stress; IMP:TAIR.
DR GO; GO:0010114; P:response to red light; IEP:UniProtKB.
DR GO; GO:0009611; P:response to wounding; IEP:UniProtKB.
DR GO; GO:0010043; P:response to zinc ion; IMP:UniProtKB.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Stress response.
FT CHAIN 1..172
FT /note="Protein OXIDATIVE STRESS 3"
FT /id="PRO_0000455031"
FT REGION 34..79
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 148..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 115..122
FT /note="Nuclear localization signal 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOTIF 142..149
FT /note="Nuclear localization signal 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT COMPBIAS 36..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 88
FT /note="K->A: Abolished ability to confer tolerance to
FT stress (e.g. metals and oxidizing chemicals such as Cd, As,
FT Cu, diamide or t-BOOH); when associated with A-89, A-91, A-
FT 92, A-98, A-99, A-101 and A-102."
FT /evidence="ECO:0000269|PubMed:18980652"
FT MUTAGEN 89
FT /note="R->A: Abolished ability to confer tolerance to
FT stress (e.g. metals and oxidizing chemicals such as Cd, As,
FT Cu, diamide or t-BOOH); when associated with A-88, A-91, A-
FT 92, A-98, A-99, A-101 and A-102."
FT /evidence="ECO:0000269|PubMed:18980652"
FT MUTAGEN 91
FT /note="L->A: Abolished ability to confer tolerance to
FT stress (e.g. metals and oxidizing chemicals such as Cd, As,
FT Cu, diamide or t-BOOH); when associated with A-88, A-89, A-
FT 92, A-98, A-99, A-101 and A-102."
FT /evidence="ECO:0000269|PubMed:18980652"
FT MUTAGEN 92
FT /note="S->A: Abolished ability to confer tolerance to
FT stress (e.g. metals and oxidizing chemicals such as Cd, As,
FT Cu, diamide or t-BOOH); when associated with A-88, A-89, A-
FT 91, A-98, A-99, A-101 and A-102."
FT /evidence="ECO:0000269|PubMed:18980652"
FT MUTAGEN 98
FT /note="K->A: Abolished ability to confer tolerance to
FT stress (e.g. metals and oxidizing chemicals such as Cd, As,
FT Cu, diamide or t-BOOH); when associated with A-88, A-89, A-
FT 91, A-92, A-99, A-101 and A-102."
FT /evidence="ECO:0000269|PubMed:18980652"
FT MUTAGEN 99
FT /note="S->A: Abolished ability to confer tolerance to
FT stress (e.g. metals and oxidizing chemicals such as Cd, As,
FT Cu, diamide or t-BOOH); when associated with A-88, A-89, A-
FT 91, A-92, A-98, A-101 and A-102."
FT /evidence="ECO:0000269|PubMed:18980652"
FT MUTAGEN 101
FT /note="S->A: Abolished ability to confer tolerance to
FT stress (e.g. metals and oxidizing chemicals such as Cd, As,
FT Cu, diamide or t-BOOH); when associated with A-88, A-89, A-
FT 91, A-92, A-98, A-99 and A-102."
FT /evidence="ECO:0000269|PubMed:18980652"
FT MUTAGEN 102
FT /note="F->A: Abolished ability to confer tolerance to
FT stress (e.g. metals and oxidizing chemicals such as Cd, As,
FT Cu, diamide or t-BOOH); when associated with A-88, A-89, A-
FT 91, A-92, A-98, A-99 and A-101."
FT /evidence="ECO:0000269|PubMed:18980652"
SQ SEQUENCE 172 AA; 19307 MW; 9FF1736A633C2AC1 CRC64;
MFKEMNLNLK QMGNMIYEDP TRIQEEEDIV QEVSTTFSDE EDNSSSCSLS SSMCSDFTED
DDDDDVSSSS SNGPLEDLSD LMSHLPIKRG LSKFYEGKSQ SFTSLGNVKS LEDLMKRGFK
SRNYGAKRKS SRSTGGILDQ SYKRVFSPKA TISKKPNRTP SSVLSCLARR RH
