ASF1A_ARATH
ID ASF1A_ARATH Reviewed; 196 AA.
AC Q9C9M6;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Probable histone chaperone ASF1A;
DE AltName: Full=Anti-silencing function protein 1-like protein a;
DE Short=Anti-silencing function 1a protein;
DE AltName: Full=S-locus protein 7;
DE Short=AtSP7;
DE AltName: Full=Silencing group A protein 2;
GN Name=ASF1A; Synonyms=SGA2, SP7; OrderedLocusNames=At1g66740;
GN ORFNames=F4N21.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Kaya H., Lee J., Araki T., Shibahara K.;
RT "Arabidopsis thaliana ASF1 genes.";
RL Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=11759841; DOI=10.1093/dnares/8.5.215;
RA Takada Y., Ito A., Ninomiya C., Kakizaki T., Takahata Y., Suzuki G.,
RA Hatakeyama K., Hinata K., Shiba H., Takayama S., Isogai A., Watanabe M.;
RT "Characterization of expressed genes in the SLL2 region of self-compatible
RT Arabidopsis thaliana.";
RL DNA Res. 8:215-219(2001).
RN [6]
RP SUBCELLULAR LOCATION, AND INTERACTION WITH HIRA.
RC STRAIN=cv. Columbia;
RX PubMed=25086063; DOI=10.1242/bio.20148680;
RA Nie X., Wang H., Li J., Holec S., Berger F.;
RT "The HIRA complex that deposits the histone H3.3 is conserved in
RT Arabidopsis and facilitates transcriptional dynamics.";
RL Biol. Open 3:794-802(2014).
CC -!- FUNCTION: Histone chaperone that facilitates histone deposition and
CC histone exchange and removal during nucleosome assembly and disassembly
CC (By similarity). While encoded by a region of the Arabidopsis thaliana
CC genome that is homologous to the Brassica S-locus for self
CC incompatibility, this protein may not play the same role in Arabidopsis
CC thaliana. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with histone H3 and histone H4 (By similarity).
CC Component of the HIRA complex made of UBN1, UBN2, ASF1A, CABIN1 and
CC HIRA. Interacts with HIRA (PubMed:25086063). {ECO:0000250,
CC ECO:0000269|PubMed:25086063}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25086063}. Nucleus,
CC nucleolus {ECO:0000269|PubMed:25086063}. Note=Localized at rDNA loci in
CC the nucleolus. {ECO:0000269|PubMed:25086063}.
CC -!- TISSUE SPECIFICITY: Expressed in leaves and flower buds.
CC {ECO:0000269|PubMed:11759841}.
CC -!- SIMILARITY: Belongs to the ASF1 family. {ECO:0000305}.
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DR EMBL; AB078339; BAC54103.1; -; mRNA.
DR EMBL; AC013288; AAG60078.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34550.1; -; Genomic_DNA.
DR EMBL; AY096540; AAM20190.1; -; mRNA.
DR EMBL; AY065298; AAL38774.1; -; mRNA.
DR RefSeq; NP_176846.1; NM_105344.4.
DR AlphaFoldDB; Q9C9M6; -.
DR SMR; Q9C9M6; -.
DR BioGRID; 28213; 1.
DR STRING; 3702.AT1G66740.1; -.
DR PaxDb; Q9C9M6; -.
DR PRIDE; Q9C9M6; -.
DR ProteomicsDB; 246677; -.
DR EnsemblPlants; AT1G66740.1; AT1G66740.1; AT1G66740.
DR GeneID; 842992; -.
DR Gramene; AT1G66740.1; AT1G66740.1; AT1G66740.
DR KEGG; ath:AT1G66740; -.
DR Araport; AT1G66740; -.
DR TAIR; locus:2033359; AT1G66740.
DR eggNOG; KOG3265; Eukaryota.
DR HOGENOM; CLU_060354_1_2_1; -.
DR InParanoid; Q9C9M6; -.
DR OMA; FYVNNDY; -.
DR OrthoDB; 1334998at2759; -.
DR PhylomeDB; Q9C9M6; -.
DR PRO; PR:Q9C9M6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C9M6; baseline and differential.
DR Genevisible; Q9C9M6; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005730; C:nucleolus; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0030875; C:rDNA protrusion; IDA:UniProtKB.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IMP:TAIR.
DR GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IBA:GO_Central.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:TAIR.
DR GO; GO:0031567; P:mitotic cell size control checkpoint signaling; IMP:TAIR.
DR GO; GO:0008361; P:regulation of cell size; IMP:TAIR.
DR GO; GO:0010091; P:trichome branching; IMP:TAIR.
DR Gene3D; 2.60.40.1490; -; 1.
DR InterPro; IPR006818; ASF1-like.
DR InterPro; IPR036747; ASF1-like_sf.
DR PANTHER; PTHR12040; PTHR12040; 1.
DR Pfam; PF04729; ASF1_hist_chap; 1.
DR SUPFAM; SSF101546; SSF101546; 1.
PE 1: Evidence at protein level;
KW Chaperone; Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..196
FT /note="Probable histone chaperone ASF1A"
FT /id="PRO_0000270797"
FT REGION 146..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 196 AA; 22133 MW; 259D9842EA77F115 CRC64;
MSAIKITNVA VLHNPAPFVS PFQFEISYEC LNSLKDDLEW KLIYVGSAED ETYDQLLESV
LVGPVNVGNY RFVFQADPPD PSKIQEEDII GVTVLLLTCS YMGQEFLRVG YYVNNDYEDE
QLKEEPPTKV LIDKVQRNIL SDKPRVTKFP IDFHPEEEQT AATAAPPEQS DEQQPNVNGE
AQVLPDQSVE PKPEES
