OXYR_BOVIN
ID OXYR_BOVIN Reviewed; 391 AA.
AC P56449;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Oxytocin receptor;
DE Short=OT-R;
GN Name=OXTR;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8534370; DOI=10.1089/dna.1995.14.1037;
RA Bathgate R., Rust W., Balvers M., Hartung S., Morley S., Ivell R.;
RT "Structure and expression of the bovine oxytocin receptor gene.";
RL DNA Cell Biol. 14:1037-1048(1995).
CC -!- FUNCTION: Receptor for oxytocin. The activity of this receptor is
CC mediated by G proteins which activate a phosphatidylinositol-calcium
CC second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; AF101724; AAC70786.1; -; mRNA.
DR RefSeq; NP_776559.1; NM_174134.2.
DR AlphaFoldDB; P56449; -.
DR SMR; P56449; -.
DR STRING; 9913.ENSBTAP00000026346; -.
DR PaxDb; P56449; -.
DR PRIDE; P56449; -.
DR Ensembl; ENSBTAT00000026346; ENSBTAP00000026346; ENSBTAG00000019772.
DR GeneID; 281371; -.
DR KEGG; bta:281371; -.
DR CTD; 5021; -.
DR VEuPathDB; HostDB:ENSBTAG00000019772; -.
DR VGNC; VGNC:32516; OXTR.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244882; -.
DR HOGENOM; CLU_009579_15_3_1; -.
DR InParanoid; P56449; -.
DR OMA; SACYGLI; -.
DR OrthoDB; 890925at2759; -.
DR TreeFam; TF106499; -.
DR Reactome; R-BTA-388479; Vasopressin-like receptors.
DR Reactome; R-BTA-416476; G alpha (q) signalling events.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000019772; Expressed in myometrium and 49 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004990; F:oxytocin receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0005000; F:vasopressin receptor activity; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0060137; P:maternal process involved in parturition; IBA:GO_Central.
DR GO; GO:0045777; P:positive regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002062; Oxytocn_rcpt.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR PANTHER; PTHR24241:SF89; PTHR24241:SF89; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00665; OXYTOCINR.
DR PRINTS; PR00896; VASOPRESSINR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..391
FT /note="Oxytocin receptor"
FT /id="PRO_0000069997"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..277
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..296
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..311
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..334
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..391
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 368
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70536"
FT MOD_RES 370
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70536"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 15
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 112..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 391 AA; 43378 MW; 39161BE63C5C672B CRC64;
MEGAFAANWS AEAVNGSAAP PGTEGNRTAG PPQRNEALAR VEVAVLCLIL FLALSGNACV
LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV
VGMFASTYLL LLMSLDRCLA ICQPLRSLSR RTDRLAVLVT WLGCLVASAP QVHIFSLREV
ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLATCY GLISFKIWQN LRLKTAAAAA
EAAAGAEGEA ADWAGRAILA RVSNVKLISK AKIRTVKMTF IVVLAFIVCW TPFFFVQMWS
VWDADAPKEA SPFIIAMLLA SLNSCCNPWI YMLFTGHLFQ ELVQRFLCCS FRRLKGSRPG
ETSVSKKSNS STFVLSQYSS SQRRCSQPST L
