ID   OXYR_HAEIN              Reviewed;         301 AA.
AC   P44418;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Hydrogen peroxide-inducible genes activator;
GN   Name=oxyR; OrderedLocusNames=HI_0571;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NTHi TN106;
RX   PubMed=8890216; DOI=10.1128/iai.64.11.4618-4629.1996;
RA   Maciver I., Hansen E.J.;
RT   "Lack of expression of the global regulator OxyR in Haemophilus influenzae
RT   has a profound effect on growth phenotype.";
RL   Infect. Immun. 64:4618-4629(1996).
CC   -!- FUNCTION: Required for the induction of a regulon of hydrogen peroxide
CC       inducible genes such as catalase and glutathione-reductase.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC22229.1; -; Genomic_DNA.
DR   EMBL; U49355; AAB48948.1; -; Genomic_DNA.
DR   PIR; C64078; C64078.
DR   RefSeq; NP_438728.1; NC_000907.1.
DR   RefSeq; WP_005649559.1; NC_000907.1.
DR   AlphaFoldDB; P44418; -.
DR   SMR; P44418; -.
DR   STRING; 71421.HI_0571; -.
DR   EnsemblBacteria; AAC22229; AAC22229; HI_0571.
DR   KEGG; hin:HI_0571; -.
DR   PATRIC; fig|71421.8.peg.591; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_4_6; -.
DR   OMA; DQALDIC; -.
DR   PhylomeDB; P44418; -.
DR   BioCyc; HINF71421:G1GJ1-583-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..301
FT                   /note="Hydrogen peroxide-inducible genes activator"
FT                   /id="PRO_0000105733"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   301 AA;  33761 MW;  1CAF1FBC3E41F9DE CRC64;
     MNIRDLEYLV ALSEYKHFRR AADSCNVSQP TLSGQIRKLE DELGIILLER TSRKVLFTQS
     GMLLVDQART VLREVKLLKE MASNQGKEMT GPLHIGLIPT VGPYLLPYIV PMLKAAFPDL
     EVFLYEAQTH QLLEQLETGR LDCAIVATVP ETEAFIEVPI FNEKMLLAVS EHHPWAQESK
     LPMNQLNGQE MLMLDDGHCL RNQALDYCFT AGAKENSHFQ ATSLETLRNM VAANAGITFM
     PELAVLNEGT RKGVKYIPCY SPEPSRTIAL VYRPGSPLRN RYERVASAVS DEVKSILDGL
     K