OXYR_HUMAN
ID OXYR_HUMAN Reviewed; 389 AA.
AC P30559; Q15071;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 187.
DE RecName: Full=Oxytocin receptor;
DE Short=OT-R;
GN Name=OXTR;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT THR-218.
RC TISSUE=Uterus;
RX PubMed=1313946; DOI=10.1038/356526a0;
RA Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.;
RT "Structure and expression of a human oxytocin receptor.";
RL Nature 356:526-529(1992).
RN [2]
RP ERRATUM OF PUBMED:1313946, AND SEQUENCE REVISION.
RA Kimura T., Tanizawa O., Mori K., Brownstein M.J., Okayama H.;
RL Nature 357:176-176(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-218.
RC TISSUE=Ovary;
RA Kopatz S.A., Aronstam R.S., Sharma S.V.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-308.
RX PubMed=7798245; DOI=10.1016/s0021-9258(18)31656-9;
RA Inoue T., Kimura T., Azuma C., Inazawa J., Takemura M., Kikuchi T.,
RA Kubota Y., Ogita K., Saji F.;
RT "Structural organization of the human oxytocin receptor gene.";
RL J. Biol. Chem. 269:32451-32456(1994).
CC -!- FUNCTION: Receptor for oxytocin. The activity of this receptor is
CC mediated by G proteins which activate a phosphatidylinositol-calcium
CC second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Wikipedia; Note=Oxytocin entry;
CC URL="https://en.wikipedia.org/wiki/Oxytocin";
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DR EMBL; X64878; CAA46097.1; -; mRNA.
DR EMBL; AY389507; AAQ91333.1; -; mRNA.
DR EMBL; X80282; CAA56562.1; -; Genomic_DNA.
DR CCDS; CCDS2570.1; -.
DR PIR; A55493; A55493.
DR RefSeq; NP_000907.2; NM_000916.3.
DR RefSeq; XP_011532064.1; XM_011533762.2.
DR PDB; 6TPK; X-ray; 3.20 A; A=35-356.
DR PDB; 7RYC; EM; 2.90 A; O=1-389.
DR PDBsum; 6TPK; -.
DR PDBsum; 7RYC; -.
DR AlphaFoldDB; P30559; -.
DR SMR; P30559; -.
DR BioGRID; 111061; 14.
DR ELM; P30559; -.
DR IntAct; P30559; 18.
DR MINT; P30559; -.
DR STRING; 9606.ENSP00000324270; -.
DR BindingDB; P30559; -.
DR ChEMBL; CHEMBL2049; -.
DR DrugBank; DB09059; Atosiban.
DR DrugBank; DB01282; Carbetocin.
DR DrugBank; DB00107; Oxytocin.
DR DrugBank; DB13929; Relcovaptan.
DR DrugBank; DB00067; Vasopressin.
DR DrugCentral; P30559; -.
DR GuidetoPHARMACOLOGY; 369; -.
DR TCDB; 9.A.14.10.4; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; P30559; 3 sites.
DR iPTMnet; P30559; -.
DR PhosphoSitePlus; P30559; -.
DR BioMuta; OXTR; -.
DR DMDM; 143811431; -.
DR MassIVE; P30559; -.
DR MaxQB; P30559; -.
DR PaxDb; P30559; -.
DR PeptideAtlas; P30559; -.
DR PRIDE; P30559; -.
DR ProteomicsDB; 54722; -.
DR Antibodypedia; 10144; 382 antibodies from 35 providers.
DR DNASU; 5021; -.
DR Ensembl; ENST00000316793.8; ENSP00000324270.2; ENSG00000180914.11.
DR GeneID; 5021; -.
DR KEGG; hsa:5021; -.
DR MANE-Select; ENST00000316793.8; ENSP00000324270.2; NM_000916.4; NP_000907.2.
DR UCSC; uc003brc.4; human.
DR CTD; 5021; -.
DR DisGeNET; 5021; -.
DR GeneCards; OXTR; -.
DR HGNC; HGNC:8529; OXTR.
DR HPA; ENSG00000180914; Group enriched (brain, breast).
DR MIM; 167055; gene.
DR neXtProt; NX_P30559; -.
DR OpenTargets; ENSG00000180914; -.
DR PharmGKB; PA32858; -.
DR VEuPathDB; HostDB:ENSG00000180914; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244882; -.
DR HOGENOM; CLU_009579_15_3_1; -.
DR InParanoid; P30559; -.
DR OMA; SACYGLI; -.
DR OrthoDB; 243095at2759; -.
DR PhylomeDB; P30559; -.
DR TreeFam; TF106499; -.
DR PathwayCommons; P30559; -.
DR Reactome; R-HSA-388479; Vasopressin-like receptors.
DR Reactome; R-HSA-416476; G alpha (q) signalling events.
DR SignaLink; P30559; -.
DR SIGNOR; P30559; -.
DR BioGRID-ORCS; 5021; 15 hits in 1080 CRISPR screens.
DR GeneWiki; Oxytocin_receptor; -.
DR GenomeRNAi; 5021; -.
DR Pharos; P30559; Tclin.
DR PRO; PR:P30559; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; P30559; protein.
DR Bgee; ENSG00000180914; Expressed in decidua and 141 other tissues.
DR ExpressionAtlas; P30559; baseline and differential.
DR Genevisible; P30559; HS.
DR GO; GO:0005912; C:adherens junction; IEA:Ensembl.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004990; F:oxytocin receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0017046; F:peptide hormone binding; IEA:Ensembl.
DR GO; GO:0005000; F:vasopressin receptor activity; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:ProtInc.
DR GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
DR GO; GO:0042755; P:eating behavior; IEA:Ensembl.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
DR GO; GO:0044849; P:estrous cycle; IEA:Ensembl.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0007595; P:lactation; TAS:ProtInc.
DR GO; GO:0042711; P:maternal behavior; IEA:Ensembl.
DR GO; GO:0060137; P:maternal process involved in parturition; IBA:GO_Central.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0006936; P:muscle contraction; TAS:ProtInc.
DR GO; GO:0060455; P:negative regulation of gastric acid secretion; IEA:Ensembl.
DR GO; GO:0045777; P:positive regulation of blood pressure; IEA:Ensembl.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; ISS:YuBioLab.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0010701; P:positive regulation of norepinephrine secretion; IEA:Ensembl.
DR GO; GO:0060406; P:positive regulation of penile erection; IEA:Ensembl.
DR GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; IEA:Ensembl.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
DR GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
DR GO; GO:0034059; P:response to anoxia; IEA:Ensembl.
DR GO; GO:0042220; P:response to cocaine; IEA:Ensembl.
DR GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
DR GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
DR GO; GO:0032570; P:response to progesterone; IEA:Ensembl.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0030431; P:sleep; IEA:Ensembl.
DR GO; GO:0035176; P:social behavior; IEA:Ensembl.
DR GO; GO:0042713; P:sperm ejaculation; IEA:Ensembl.
DR GO; GO:0001967; P:suckling behavior; IEA:Ensembl.
DR GO; GO:0021537; P:telencephalon development; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002062; Oxytocn_rcpt.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR PANTHER; PTHR24241:SF89; PTHR24241:SF89; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00665; OXYTOCINR.
DR PRINTS; PR00896; VASOPRESSINR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Phosphoprotein; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..389
FT /note="Oxytocin receptor"
FT /id="PRO_0000069998"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..275
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..294
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..332
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 333..389
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 7..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 366
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70536"
FT MOD_RES 368
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70536"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 15
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 112..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 16
FT /note="A -> S (in dbSNP:rs237906)"
FT /id="VAR_031570"
FT VARIANT 218
FT /note="A -> T (in dbSNP:rs4686302)"
FT /evidence="ECO:0000269|PubMed:1313946, ECO:0000269|Ref.3"
FT /id="VAR_031571"
FT CONFLICT 308
FT /note="A -> G (in Ref. 4; CAA56562)"
FT /evidence="ECO:0000305"
FT HELIX 36..63
FT /evidence="ECO:0007829|PDB:6TPK"
FT HELIX 74..101
FT /evidence="ECO:0007829|PDB:6TPK"
FT HELIX 109..142
FT /evidence="ECO:0007829|PDB:6TPK"
FT STRAND 144..146
FT /evidence="ECO:0007829|PDB:6TPK"
FT HELIX 150..174
FT /evidence="ECO:0007829|PDB:6TPK"
FT STRAND 175..183
FT /evidence="ECO:0007829|PDB:6TPK"
FT STRAND 185..189
FT /evidence="ECO:0007829|PDB:6TPK"
FT HELIX 196..208
FT /evidence="ECO:0007829|PDB:6TPK"
FT HELIX 210..228
FT /evidence="ECO:0007829|PDB:6TPK"
FT HELIX 268..298
FT /evidence="ECO:0007829|PDB:6TPK"
FT HELIX 307..332
FT /evidence="ECO:0007829|PDB:6TPK"
FT HELIX 334..336
FT /evidence="ECO:0007829|PDB:6TPK"
FT TURN 342..344
FT /evidence="ECO:0007829|PDB:6TPK"
FT HELIX 349..351
FT /evidence="ECO:0007829|PDB:6TPK"
SQ SEQUENCE 389 AA; 42772 MW; 97E1845DA9676439 CRC64;
MEGALAANWS AEAANASAAP PGAEGNRTAG PPRRNEALAR VEVAVLCLIL LLALSGNACV
LLALRTTRQK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV
VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV
ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA
AEAPEGAAAG DGGRVALARV SSVKLISKAK IRTVKMTFII VLAFIVCWTP FFFVQMWSVW
DANAPKEASA FIIVMLLASL NSCCNPWIYM LFTGHLFHEL VQRFLCCSAS YLKGRRLGET
SASKKSNSSS FVLSHRSSSQ RSCSQPSTA
