OXYR_MOUSE
ID OXYR_MOUSE Reviewed; 388 AA.
AC P97926; F8VQ78;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Oxytocin receptor;
DE Short=OT-R;
GN Name=Oxtr;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=129/Sv;
RX PubMed=9027321; DOI=10.1016/s0303-7207(96)03923-8;
RA Kubota Y., Kimura T., Hashimoto K., Tokugawa Y., Nobunaga K., Azuma C.,
RA Saji F., Murata Y.;
RT "Structure and expression of the mouse oxytocin receptor gene.";
RL Mol. Cell. Endocrinol. 124:25-32(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Receptor for oxytocin. The activity of this receptor is
CC mediated by G proteins which activate a phosphatidylinositol-calcium
CC second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; D86599; BAA18995.1; -; mRNA.
DR EMBL; D86631; BAA18996.1; -; Genomic_DNA.
DR EMBL; AC153594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS39588.1; -.
DR RefSeq; NP_001074616.1; NM_001081147.1.
DR RefSeq; XP_006505786.1; XM_006505723.1.
DR AlphaFoldDB; P97926; -.
DR SMR; P97926; -.
DR STRING; 10090.ENSMUSP00000051132; -.
DR BindingDB; P97926; -.
DR ChEMBL; CHEMBL3243907; -.
DR GuidetoPHARMACOLOGY; 369; -.
DR GlyGen; P97926; 2 sites.
DR iPTMnet; P97926; -.
DR PhosphoSitePlus; P97926; -.
DR PaxDb; P97926; -.
DR PRIDE; P97926; -.
DR ProteomicsDB; 294414; -.
DR Antibodypedia; 10144; 382 antibodies from 35 providers.
DR DNASU; 18430; -.
DR Ensembl; ENSMUST00000053306; ENSMUSP00000051132; ENSMUSG00000049112.
DR GeneID; 18430; -.
DR KEGG; mmu:18430; -.
DR UCSC; uc009deb.1; mouse.
DR CTD; 5021; -.
DR MGI; MGI:109147; Oxtr.
DR VEuPathDB; HostDB:ENSMUSG00000049112; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244882; -.
DR HOGENOM; CLU_009579_15_3_1; -.
DR InParanoid; P97926; -.
DR OMA; SACYGLI; -.
DR OrthoDB; 890925at2759; -.
DR PhylomeDB; P97926; -.
DR TreeFam; TF106499; -.
DR Reactome; R-MMU-388479; Vasopressin-like receptors.
DR Reactome; R-MMU-416476; G alpha (q) signalling events.
DR BioGRID-ORCS; 18430; 4 hits in 74 CRISPR screens.
DR PRO; PR:P97926; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P97926; protein.
DR Bgee; ENSMUSG00000049112; Expressed in metanephric renal vesicle and 86 other tissues.
DR ExpressionAtlas; P97926; baseline and differential.
DR Genevisible; P97926; MM.
DR GO; GO:0005912; C:adherens junction; ISO:MGI.
DR GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005902; C:microvillus; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004990; F:oxytocin receptor activity; ISO:MGI.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0017046; F:peptide hormone binding; ISO:MGI.
DR GO; GO:0005000; F:vasopressin receptor activity; IBA:GO_Central.
DR GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
DR GO; GO:0042755; P:eating behavior; ISO:MGI.
DR GO; GO:0070371; P:ERK1 and ERK2 cascade; ISO:MGI.
DR GO; GO:0044849; P:estrous cycle; IEA:Ensembl.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:MGI.
DR GO; GO:0007507; P:heart development; IEA:Ensembl.
DR GO; GO:0042711; P:maternal behavior; ISO:MGI.
DR GO; GO:0060137; P:maternal process involved in parturition; IBA:GO_Central.
DR GO; GO:0007613; P:memory; ISO:MGI.
DR GO; GO:0060455; P:negative regulation of gastric acid secretion; ISO:MGI.
DR GO; GO:0045777; P:positive regulation of blood pressure; IGI:MGI.
DR GO; GO:0120162; P:positive regulation of cold-induced thermogenesis; IMP:YuBioLab.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR GO; GO:0010701; P:positive regulation of norepinephrine secretion; ISO:MGI.
DR GO; GO:0060406; P:positive regulation of penile erection; ISO:MGI.
DR GO; GO:0051965; P:positive regulation of synapse assembly; ISO:MGI.
DR GO; GO:0032230; P:positive regulation of synaptic transmission, GABAergic; ISO:MGI.
DR GO; GO:0051968; P:positive regulation of synaptic transmission, glutamatergic; ISO:MGI.
DR GO; GO:0070474; P:positive regulation of uterine smooth muscle contraction; ISO:MGI.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0044058; P:regulation of digestive system process; ISO:MGI.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR GO; GO:0001975; P:response to amphetamine; ISO:MGI.
DR GO; GO:0034059; P:response to anoxia; ISO:MGI.
DR GO; GO:0042220; P:response to cocaine; IEA:Ensembl.
DR GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
DR GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
DR GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
DR GO; GO:0032570; P:response to progesterone; IEA:Ensembl.
DR GO; GO:0048545; P:response to steroid hormone; ISO:MGI.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0030431; P:sleep; ISO:MGI.
DR GO; GO:0035176; P:social behavior; ISO:MGI.
DR GO; GO:0042713; P:sperm ejaculation; ISO:MGI.
DR GO; GO:0001967; P:suckling behavior; ISO:MGI.
DR GO; GO:0021537; P:telencephalon development; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002062; Oxytocn_rcpt.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR PANTHER; PTHR24241:SF89; PTHR24241:SF89; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00665; OXYTOCINR.
DR PRINTS; PR00896; VASOPRESSINR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..388
FT /note="Oxytocin receptor"
FT /id="PRO_0000070000"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..293
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..308
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..331
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 332..388
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 354..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 365
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70536"
FT MOD_RES 367
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70536"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 112..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 375
FT /note="R -> C (in Ref. 1; BAA18995)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 388 AA; 42805 MW; 77FF8829ACAB4785 CRC64;
MEGTPAANWS IELDLGSGVP PGAEGNLTAG PPRRNEALAR VEVAVLCLIL FLALSGNACV
LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV
VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASVP QVHIFSLREV
ADGVFDCWAV FIQPWGPKAY VTWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAAAA
AAEGSDAAGG AGRAALARVS SVKLISKAKI RTVKMTFIIV LAFIVCWTPF FFVQMWSVWD
VNAPKEASAF IIAMLLASLN SCCNPWIYML FTGHLFHELV QRFLCCSARY LKGSRPGETS
ISKKSNSSTF VLSRRSSSQR SCSQPSSA
