ID   OXYR_MYCAV              Reviewed;         311 AA.
AC   P52677;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Probable hydrogen peroxide-inducible genes activator;
GN   Name=oxyR;
OS   Mycobacterium avium.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=1764;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7604044; DOI=10.1073/pnas.92.14.6625;
RA   Sherman D.R., Sabo P.J., Hickey M.J., Arain T.M., Mahairas G.G., Yuan Y.,
RA   Barry C.E. III, Stover C.K.;
RT   "Disparate responses to oxidative stress in saprophytic and pathogenic
RT   mycobacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:6625-6629(1995).
CC   -!- FUNCTION: Required for the induction the katG gene for catalase.
CC       Involved in the response to hydrogen peroxide.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; U18263; AAA79918.1; -; Genomic_DNA.
DR   PIR; T09656; T09656.
DR   RefSeq; WP_009976952.1; NZ_CP028731.1.
DR   AlphaFoldDB; P52677; -.
DR   SMR; P52677; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..311
FT                   /note="Probable hydrogen peroxide-inducible genes
FT                   activator"
FT                   /id="PRO_0000105734"
FT   DOMAIN          8..65
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        25..44
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   311 AA;  32527 MW;  9919F2FE5B918CBA CRC64;
     MPDKTYQPTI AGLRAFVAVA EKRQFSGAAT ALGVSQSTLS QVLAALEAGL GTQLVERSTR
     RVFLTPQGAE LLPHAQAVVE AADAFTAAAA GSTDPLRAGM RLGLIPTVVP YVLPTVLAGI
     AERRPGLTLR VTEDQTERLL AVLREGALDA ALIALPAETA GVTAIPIYDE DFVLALPPGH
     PLAGKRRVPA TALADLPLLL LDEGHCLRDQ ALDVCHKAGV RAELANTRAA SLATAVQCVT
     GGLGVTLIPQ SAVPVEASRS RLGLAQFAAP RPGRRIGLVF RSSSGRDDSY RELAGLIGEL
     ISSQHQVRLV K