ID   OXYR_MYCLE              Reviewed;         311 AA.
AC   P52678;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 122.
DE   RecName: Full=Probable hydrogen peroxide-inducible genes activator;
GN   Name=oxyR; OrderedLocusNames=ML2041;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8006590; DOI=10.1084/jem.180.1.319;
RA   Pessolani M.C.V., Smith D.R., Rivoire B., McCormick J., Hefta S.A.,
RA   Cole S.T., Brennan P.J.;
RT   "Purification, characterization, gene sequence, and significance of a
RT   bacterioferritin from Mycobacterium leprae.";
RL   J. Exp. Med. 180:319-327(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Required for the induction the katG gene for catalase.
CC       Involved in the response to hydrogen peroxide (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; L01095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL583924; CAC30996.1; -; Genomic_DNA.
DR   PIR; D87164; D87164.
DR   RefSeq; NP_302364.1; NC_002677.1.
DR   RefSeq; WP_010908684.1; NC_002677.1.
DR   AlphaFoldDB; P52678; -.
DR   SMR; P52678; -.
DR   STRING; 272631.ML2041; -.
DR   EnsemblBacteria; CAC30996; CAC30996; CAC30996.
DR   KEGG; mle:ML2041; -.
DR   PATRIC; fig|272631.5.peg.3846; -.
DR   Leproma; ML2041; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_4_11; -.
DR   OMA; DQALDIC; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..311
FT                   /note="Probable hydrogen peroxide-inducible genes
FT                   activator"
FT                   /id="PRO_0000105735"
FT   DOMAIN          8..65
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        25..44
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   311 AA;  32840 MW;  2B7364A61EFDF62E CRC64;
     MSDKSYQPTI AGLRAFVAVV EKGHFSAAAS FLGVRQSTLS QALAALESGL GVQLIERSTR
     RVFVTTQGRH LLPRAQAAIE AMDAFTAAAA GESDPLRGGM RLGLIPTVAP YVLPTMLTGL
     THRLPTLTLR VVEDQTEHLL TALREGALDA AMIALPVETA GIAEIPIYDE DFVLALPPGH
     PLSGKRRVPT TALAQLPLLL LDEGHCLRDQ TLDICRKSGV QAELANTRAA SLATAVQCVT
     GGLGVTLLPQ SAAPVESVRS KLGLAQFAAP CPGRRIGLAF RSASGRSASY RQIAKIIGEL
     ISTEHHVRLV A