ID   OXYR_MYCMR              Reviewed;         311 AA.
AC   O87324;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Probable hydrogen peroxide-inducible genes activator;
GN   Name=oxyR;
OS   Mycobacterium marinum.
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1781;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 15069;
RX   PubMed=9733688; DOI=10.1128/jb.180.18.4856-4864.1998;
RA   Pagan-Ramos E., Song J., McFalone M., Mudd M.H., Deretic V.;
RT   "Oxidative stress response and characterization of the oxyR-ahpC and furA-
RT   katG loci in Mycobacterium marinum.";
RL   J. Bacteriol. 180:4856-4864(1998).
CC   -!- FUNCTION: Required for the induction the katG gene for catalase.
CC       Involved in the response to hydrogen peroxide (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AF034861; AAC61302.1; -; Genomic_DNA.
DR   RefSeq; WP_036455666.1; NZ_PQBO01000103.1.
DR   AlphaFoldDB; O87324; -.
DR   SMR; O87324; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..311
FT                   /note="Probable hydrogen peroxide-inducible genes
FT                   activator"
FT                   /id="PRO_0000105736"
FT   DOMAIN          8..65
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        25..44
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   311 AA;  32865 MW;  8111B2726090C096 CRC64;
     MTDKSYQPTL AGLRAFVAVA EKQHFGSAAN ALGVSQSTLS QALAALEAGL NLHLVERSTR
     RVFLTTEGRS LLPHAQAAVE AVEAFTTAAA GEADPLNGSI RFGIIPTVAP YVLPTVLAGL
     TRRLPTLTVR VIEDQTERLL TALREGSLDT ALIALPADYR GLTEMPIYEE DFVLALPPGH
     PMADRHGVPV AALSELPLLL LDEGHCLRDQ ALDVCQNAGV RAELADTRAA SLATAVQCVN
     GGLGVTLIPQ SAVSVEAARS RVGLAHFAAP TPGRRIGLVY RASSGRDEAY RQLAAIMGES
     IGNEQQVRLV N