OXYR_PIG
ID OXYR_PIG Reviewed; 386 AA.
AC P32306;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Oxytocin receptor;
DE Short=OT-R;
GN Name=OXTR;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Kidney;
RX PubMed=8393786; DOI=10.1111/j.1432-1033.1993.tb18000.x;
RA Gorbulev V., Buechner H., Akhundova A., Fahrenholz F.;
RT "Molecular cloning and functional characterization of V2 [8-lysine]
RT vasopressin and oxytocin receptors from a pig kidney cell line.";
RL Eur. J. Biochem. 215:1-7(1993).
CC -!- FUNCTION: Receptor for oxytocin. The activity of this receptor is
CC mediated by G proteins which activate a phosphatidylinositol-calcium
CC second messenger system.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; X71796; CAA50679.1; -; mRNA.
DR PIR; S34043; S34043.
DR RefSeq; NP_999192.1; NM_214027.1.
DR AlphaFoldDB; P32306; -.
DR SMR; P32306; -.
DR STRING; 9823.ENSSSCP00000023004; -.
DR PaxDb; P32306; -.
DR PRIDE; P32306; -.
DR GeneID; 397092; -.
DR KEGG; ssc:397092; -.
DR CTD; 5021; -.
DR eggNOG; KOG3656; Eukaryota.
DR InParanoid; P32306; -.
DR OrthoDB; 890925at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004990; F:oxytocin receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0005000; F:vasopressin receptor activity; IBA:GO_Central.
DR GO; GO:0007565; P:female pregnancy; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0060137; P:maternal process involved in parturition; IBA:GO_Central.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002062; Oxytocn_rcpt.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR PANTHER; PTHR24241:SF89; PTHR24241:SF89; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00665; OXYTOCINR.
DR PRINTS; PR00896; VASOPRESSINR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..386
FT /note="Oxytocin receptor"
FT /id="PRO_0000070001"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..202
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..277
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..296
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 297..311
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..334
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 335..386
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 368
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70536"
FT MOD_RES 370
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P70536"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 15
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 26
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 112..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 386 AA; 42524 MW; E9D38BBAA48685DC CRC64;
MEGVLAANWS AEAVNSSAAP PEAEGNRTAG PPQRNEALAR VEVAVLCLIL FLALSGNACV
LLALRTTRHK HSRLFFFMKH LSIADLVVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV
VGMFASTYLL LLMSLDRCLA ICQPLRALRR PADRLAVLAT WLGCLVASAP QVHIFSLREV
ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTAAEAA
EAIAGTEGAA AGSRGRAALA RVSSVKLISK AKIRTVKMTF IIVLAFIVCW TPFFFVQMWS
VWDADAPKEA SAFIIAMLLA SLNSCCNPWI YMLFTGHLFH ELVQRFLCCS SSHLKTSRPG
ETSVSKKSNS STFVLSQHSS SQKSCS
