ID   OXYR_SHEEP              Reviewed;         391 AA.
AC   Q28756;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Oxytocin receptor;
DE            Short=OT-R;
GN   Name=OXTR;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Endometrium;
RX   PubMed=8800644; DOI=10.1677/jme.0.0150195;
RA   Riley P.R., Flint A.P.F., Abayasekara D.R.E., Stewart H.J.;
RT   "Structure and expression of an ovine endometrial oxytocin receptor cDNA.";
RL   J. Mol. Endocrinol. 15:195-202(1995).
RN   [2]
RP   CHARACTERIZATION.
RX   PubMed=8691097; DOI=10.1677/joe.0.1490389;
RA   Riley P.R., Abayasekara D.R.E., Stewart H.J., Flint A.P.F.;
RT   "Functional characterisation of an ovine endometrial oxytocin receptor cDNA
RT   transiently expressed in Cos-7 cells.";
RL   J. Endocrinol. 149:389-396(1996).
CC   -!- FUNCTION: Receptor for oxytocin. The activity of this receptor is
CC       mediated by G proteins which activate a phosphatidylinositol-calcium
CC       second messenger system.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00521}.
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DR   EMBL; X87986; CAA61239.1; -; mRNA.
DR   AlphaFoldDB; Q28756; -.
DR   SMR; Q28756; -.
DR   STRING; 9940.ENSOARP00000008033; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004990; F:oxytocin receptor activity; IEA:InterPro.
DR   GO; GO:0005000; F:vasopressin receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002062; Oxytocn_rcpt.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   PANTHER; PTHR24241:SF89; PTHR24241:SF89; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00665; OXYTOCINR.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..391
FT                   /note="Oxytocin receptor"
FT                   /id="PRO_0000070003"
FT   TOPO_DOM        1..38
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..63
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..74
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..97
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        98..113
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..135
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..154
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..202
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..225
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        226..277
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..296
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        297..311
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        312..334
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        335..391
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         370
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P70536"
FT   CARBOHYD        8
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        15
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        26
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        112..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   391 AA;  43271 MW;  6FE5D67C8B8E7E69 CRC64;
     MEGAFAANWS AEAVNGSAAP PGTEGNRTAG PPQRNEALAR VEVAVLSLIL FLALSGNACV
     LLALRTTRHK HSRLFFFMKH LSIADLAVAV FQVLPQLLWD ITFRFYGPDL LCRLVKYLQV
     VGMFASTYLL LLMSLDRCLA ICQPLRSLRR RTDRLAVLAT WLGCLVASAP QVHIFSLREV
     ADGVFDCWAV FIQPWGPKAY ITWITLAVYI VPVIVLAACY GLISFKIWQN LRLKTEAAAA
     EASAGAEGAA ADCAGRAALA RVSNVKLISK AKIRTVKMTF IVVLAFIVCW TPFFFKQMWS
     VWDADAPKEA SAFIIAMLLA SLNSCCNPWI YMLFTGHLFQ DLVQRFLCCS FRRLKGSQLG
     ETSVTKKIHS YTFVLSRHSS SQRSCSQPST V