ID   OXYR_STRVD              Reviewed;         312 AA.
AC   Q9X5P2;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Probable hydrogen peroxide-inducible genes activator;
GN   Name=oxyR;
OS   Streptomyces viridosporus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=67581;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=T7A;
RA   Ramachandran S., Crawford D.L.;
RT   "Genetic organization and sequence analysis of three peroxide induced
RT   regulatory genes oxyR, ahpC and ahpX in Streptomyces viridosporus T7A, a
RT   lignocellulose degrading organism.";
RL   Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the induction of a regulon of hydrogen peroxide
CC       inducible genes such as catalase and glutathione-reductase.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF127219; AAD25084.1; -; mRNA.
DR   AlphaFoldDB; Q9X5P2; -.
DR   SMR; Q9X5P2; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..312
FT                   /note="Probable hydrogen peroxide-inducible genes
FT                   activator"
FT                   /id="PRO_0000105738"
FT   DOMAIN          8..65
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        25..44
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   312 AA;  33174 MW;  9D415FCBF7238D76 CRC64;
     MRKRRRQPSL AQLRAFAAVA EHLHFRDAAA AIGMSQPALS GAVSALEESL GVTLLERTTR
     KVLLSPAGER LAARAKSVLA EVGALVEEAD ALQAPFTGVL RLGVIPTVAP YVLPTVLRLV
     HDRYPRLDLQ VHEEQTASLL DGLTGGRLDL LLLAVPLGVP GVVELPLFDE DFVLVTPLEH
     GLGGREGIPR KALRELNLLL LDEGHCLRDQ ALDICREAGS AGVAATTTAA GLSTLVQLVA
     GGLGVTLLPH TAVQVETTRS GRLLTGRFAD PAPGRRIALA MRTGAARAAE YEELAAALRE
     AMRDLPVRIV RD