ID   OXYT_EISFE              Reviewed;           9 AA.
AC   P42998;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   02-JUN-2021, entry version 53.
DE   RecName: Full=Annetocin;
OS   Eisenia fetida (Red wiggler worm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Oligochaeta; Crassiclitellata; Lumbricina; Lumbricidae; Lumbricinae;
OC   Eisenia.
OX   NCBI_TaxID=6396;
RN   [1]
RP   PROTEIN SEQUENCE, AMIDATION AT GLY-9, AND DISULFIDE BOND.
RC   TISSUE=Pituitary;
RX   PubMed=8292046; DOI=10.1006/bbrc.1994.1055;
RA   Oumi T., Ukena K., Matsushima O., Ikeda T., Fujita T., Minakata H.,
RA   Nomoto K.;
RT   "Annetocin: an oxytocin-related peptide isolated from the earthworm,
RT   Eisenia foetida.";
RL   Biochem. Biophys. Res. Commun. 198:393-399(1994).
CC   -!- FUNCTION: Potentiates spontaneous contractions of the gut and also
CC       pulsatory contractions and bladder-shaking movement of the nephridia.
CC       May be involved in osmoregulation of the animal through nephridial
CC       function.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the vasopressin/oxytocin family. {ECO:0000305}.
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DR   PIR; PC2021; PC2021.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005185; F:neurohypophyseal hormone activity; IEA:InterPro.
DR   InterPro; IPR022423; Neurohypophysial_hormone_CS.
DR   PROSITE; PS00264; NEUROHYPOPHYS_HORM; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond; Hormone; Secreted.
FT   PEPTIDE         1..9
FT                   /note="Annetocin"
FT                   /id="PRO_0000044097"
FT   MOD_RES         9
FT                   /note="Glycine amide"
FT                   /evidence="ECO:0000269|PubMed:8292046"
FT   DISULFID        1..6
FT                   /evidence="ECO:0000269|PubMed:8292046"
SQ   SEQUENCE   9 AA;  996 MW;  D4EEB76EB45412C9 CRC64;
     CFVRNCPTG