ID   OYEC_SCHPO              Reviewed;         395 AA.
AC   O94467;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Putative NADPH dehydrogenase C23G7.10c;
DE            EC=1.6.99.1;
DE   AltName: Full=Old yellow enzyme homolog 3;
GN   ORFNames=SPBC23G7.10c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + H(+) + NADPH = AH2 + NADP(+); Xref=Rhea:RHEA:13149,
CC         ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:17499,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.99.1;
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC   -!- SUBUNIT: Homodimer or heterodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NADH:flavin oxidoreductase/NADH oxidase
CC       family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA22626.1; -; Genomic_DNA.
DR   PIR; T39956; T39956.
DR   RefSeq; NP_595868.1; NM_001021774.2.
DR   AlphaFoldDB; O94467; -.
DR   SMR; O94467; -.
DR   STRING; 4896.SPBC23G7.10c.1; -.
DR   MaxQB; O94467; -.
DR   PaxDb; O94467; -.
DR   EnsemblFungi; SPBC23G7.10c.1; SPBC23G7.10c.1:pep; SPBC23G7.10c.
DR   GeneID; 2540490; -.
DR   KEGG; spo:SPBC23G7.10c; -.
DR   PomBase; SPBC23G7.10c; -.
DR   VEuPathDB; FungiDB:SPBC23G7.10c; -.
DR   eggNOG; KOG0134; Eukaryota.
DR   HOGENOM; CLU_012153_2_1_1; -.
DR   InParanoid; O94467; -.
DR   OMA; WDENHAT; -.
DR   PhylomeDB; O94467; -.
DR   PRO; PR:O94467; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0003959; F:NADPH dehydrogenase activity; ISM:PomBase.
DR   GO; GO:0018548; F:pentaerythritol trinitrate reductase activity; IEA:UniProtKB-EC.
DR   CDD; cd02932; OYE_YqiM_FMN; 1.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001155; OxRdtase_FMN_N.
DR   InterPro; IPR044152; YqjM-like.
DR   PANTHER; PTHR43303; PTHR43303; 1.
DR   Pfam; PF00724; Oxidored_FMN; 1.
PE   3: Inferred from homology;
KW   Flavoprotein; FMN; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..395
FT                   /note="Putative NADPH dehydrogenase C23G7.10c"
FT                   /id="PRO_0000314118"
FT   ACT_SITE        213
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         208
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT                   /evidence="ECO:0000250"
FT   BINDING         208
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         358
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT                   /evidence="ECO:0000250"
FT   BINDING         386
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   395 AA;  43684 MW;  EF4687841D9FDA06 CRC64;
     MTIVNEGAEN VGYFTPAQKI PAGAAIGVPQ TKLFTPLKIR GVEFHNRMFV SPMCTYSADQ
     EGHLTDFHLV HLGAMGMRGP GLVMVEATAV SPEGRISPND SGLWMESQMK PLRRIVEFAH
     SQNQKIGIQL AHAGRKASTT APYRGYTVAT EAQGGWENDV YGPNEDRWDE NHAQPHKLTE
     KQYDELVDKF VVAAKRAVEI GFDVIEIHGA HGYLISSTVS PATNDRNDKY GGTFEKRILF
     PMEVVHSVRK AIPDSMPLFY RVTATDWLPK GQGWEIEDTV ALAARLRDGG VDLIDVSSGG
     NHKDQRIEVK DCYQVPFAEK IKDQVNGILL GAVGMIRDGL TANEILESGK ADVTFVAREF
     LRNPSLVLDS ANQLGENVAW PVQYDYAVKG HRKLR