ID   OYE_STRPG               Reviewed;         399 AA.
AC   P0DN73;
DT   20-JAN-2016, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2016, sequence version 1.
DT   25-MAY-2022, entry version 17.
DE   RecName: Full=Uncharacterized oxidoreductase SpyM50865 {ECO:0000305};
DE            EC=1.-.-.- {ECO:0000305};
DE   AltName: Full=SpyOYE {ECO:0000303|PubMed:26166706};
GN   OrderedLocusNames=SpyM50865 {ECO:0000312|EMBL:CAM30193.1};
OS   Streptococcus pyogenes serotype M5 (strain Manfredo).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=160491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Manfredo;
RX   PubMed=17012393; DOI=10.1128/jb.01227-06;
RA   Holden M.T.G., Scott A., Cherevach I., Chillingworth T., Churcher C.,
RA   Cronin A., Dowd L., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA   Moule S., Mungall K., Quail M.A., Price C., Rabbinowitsch E., Sharp S.,
RA   Skelton J., Whitehead S., Barrell B.G., Kehoe M., Parkhill J.;
RT   "Complete genome of acute rheumatic fever-associated serotype M5
RT   Streptococcus pyogenes strain Manfredo.";
RL   J. Bacteriol. 189:1473-1477(2007).
RN   [2]
RP   INTERACTION WITH GCVH-L.
RC   STRAIN=Manfredo;
RX   PubMed=26166706; DOI=10.1016/j.molcel.2015.06.013;
RA   Rack J.G., Morra R., Barkauskaite E., Kraehenbuehl R., Ariza A., Qu Y.,
RA   Ortmayer M., Leidecker O., Cameron D.R., Matic I., Peleg A.Y., Leys D.,
RA   Traven A., Ahel I.;
RT   "Identification of a class of protein ADP-ribosylating sirtuins in
RT   microbial pathogens.";
RL   Mol. Cell 59:309-320(2015).
CC   -!- SUBUNIT: Directly interacts with lipoylated GcvH-L (SpyM50867).
CC       {ECO:0000269|PubMed:26166706}.
CC   -!- SIMILARITY: Belongs to the NADH:flavin oxidoreductase/NADH oxidase
CC       family. {ECO:0000305}.
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DR   EMBL; AM295007; CAM30193.1; -; Genomic_DNA.
DR   RefSeq; WP_002984549.1; NC_009332.1.
DR   AlphaFoldDB; P0DN73; -.
DR   SMR; P0DN73; -.
DR   GeneID; 57852689; -.
DR   KEGG; spf:SpyM50865; -.
DR   HOGENOM; CLU_012153_2_3_9; -.
DR   OMA; MIGFGRP; -.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001155; OxRdtase_FMN_N.
DR   Pfam; PF00724; Oxidored_FMN; 1.
PE   1: Evidence at protein level;
KW   FAD; Flavoprotein; NAD; Oxidoreductase.
FT   CHAIN           1..399
FT                   /note="Uncharacterized oxidoreductase SpyM50865"
FT                   /id="PRO_0000435349"
SQ   SEQUENCE   399 AA;  44510 MW;  FBA0E90DBD2C209A CRC64;
     MKERFSPLFE PLTLPNGSQL DNRFVLSPMV TNSSTKDGYV TQDDVSYALR RAASAPLQIT
     GAAYVDPYGQ LFEYGFSVTK DADISGLKEL AQAMKAKGAK AVLQLTHAGR FASHALTKYG
     FVYGPSYMQL RSPQPHEVKP LTGQQIEELI AAYAQATRRA IQAGFDGVEV SSAQRLLIQT
     FFSTFSNKRT DSYGCQTLFN RSKLTLAVLQ AVQQVINQEA PDGFIFGFRA TPEETRGNDI
     GYSIDEFLQL MDWVLNIAKL DYLAIASWGR HVFRNTVRSP GPYYGRRVNQ VVRDYLRNKL
     PVMATGGMNT PDKAIEALAH ADFIGVSTPF VVDPEFAHKI KEGCEESIHL RIRPADLKSL
     AIPQASFKDI VPLMDYGESL PKESRTLFRS LTHNYKEIK