OZF_PONAB
ID OZF_PONAB Reviewed; 292 AA.
AC Q5RFP4; Q5RAA6;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Zinc finger protein OZF;
DE AltName: Full=Only zinc finger protein;
DE AltName: Full=Zinc finger protein 146;
GN Name=ZNF146; Synonyms=OZF;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex, and Kidney;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Binds DNA. Interacts with SUMO conjugating enzyme UBC9/UBE2I.
CC Interacts with the telomeric protein TERF2IP (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; CR857109; CAH89413.1; -; mRNA.
DR EMBL; CR859112; CAH91304.1; -; mRNA.
DR RefSeq; NP_001124596.1; NM_001131124.2.
DR AlphaFoldDB; Q5RFP4; -.
DR SMR; Q5RFP4; -.
DR Ensembl; ENSPPYT00000011514; ENSPPYP00000011082; ENSPPYG00000009900.
DR Ensembl; ENSPPYT00000056764; ENSPPYP00000043602; ENSPPYG00000009900.
DR Ensembl; ENSPPYT00000060797; ENSPPYP00000031663; ENSPPYG00000009900.
DR GeneID; 100171432; -.
DR KEGG; pon:100171432; -.
DR CTD; 7705; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162671; -.
DR HOGENOM; CLU_002678_2_1_1; -.
DR InParanoid; Q5RFP4; -.
DR OMA; MDALDHW; -.
DR OrthoDB; 1318335at2759; -.
DR TreeFam; TF337055; -.
DR Proteomes; UP000001595; Chromosome 19.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..292
FT /note="Zinc finger protein OZF"
FT /id="PRO_0000047278"
FT ZN_FING 16..38
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 44..66
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 72..94
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 100..122
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 128..150
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 156..178
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 184..206
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 212..234
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 212..292
FT /note="Interaction with TERF2IP"
FT /evidence="ECO:0000250"
FT CROSSLNK 28
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q15072"
FT CROSSLNK 51
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q15072"
FT CROSSLNK 56
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q15072"
FT CROSSLNK 157
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO)"
FT /evidence="ECO:0000250"
FT CROSSLNK 169
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO)"
FT /evidence="ECO:0000250"
FT CROSSLNK 173
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q15072"
FT CONFLICT 30
FT /note="N -> D (in Ref. 1; CAH91304)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 292 AA; 33308 MW; D5062375D261B971 CRC64;
MSHLSQQRIY SGENPFACKV CGKVFSHKSN LTEHEHFHTR EKPFECNECG KAFSQKQYVI
KHQNTHTGEK LFECNECGKS FSQKENLLTH QKIHTGEKPF ECKDCGKAFI QKSNLIRHQR
THTGEKPFVC KECGKTFSGK SNLTEHEKIH IGEKPFKCSE CGTAFGQKKY LIKHQNIHTG
EKPYECNECG KAFSQRTSLI VHVRIHSGDK PYECNVCGKA FSQSSSLTVH VRSHTGEKPY
GCNECGKAFS QFSTLALHLR IHTGKKPYQC SECGKAFSQK SHHIRHQKIH TH
