P0_BWYVG
ID P0_BWYVG Reviewed; 218 AA.
AC Q9WIB9;
DT 19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 25-MAY-2022, entry version 37.
DE RecName: Full=Suppressor of silencing P0;
DE AltName: Full=Protein ORF0;
DE Flags: Fragment;
GN ORFNames=ORF0;
OS Beet western yellows virus (isolate GB1) (BWYV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Sobelivirales; Solemoviridae; Polerovirus.
OX NCBI_TaxID=12044;
OH NCBI_TaxID=161934; Beta vulgaris (Sugar beet).
OH NCBI_TaxID=3709; Brassica napus subsp. rapifera.
OH NCBI_TaxID=138011; Brassica napus var. napus.
OH NCBI_TaxID=3710; Brassica nigra (Black mustard) (Sinapis nigra).
OH NCBI_TaxID=3715; Brassica oleracea var. botrytis (Cauliflower).
OH NCBI_TaxID=3716; Brassica oleracea var. capitata (Cabbage).
OH NCBI_TaxID=51350; Brassica rapa subsp. rapa (Turnip).
OH NCBI_TaxID=4072; Capsicum annuum (Capsicum pepper).
OH NCBI_TaxID=3827; Cicer arietinum (Chickpea) (Garbanzo).
OH NCBI_TaxID=3654; Citrullus lanatus (Watermelon) (Citrullus vulgaris).
OH NCBI_TaxID=3721; Crambe hispanica subsp. abyssinica (Abyssinian kale) (Crambe abyssinica).
OH NCBI_TaxID=3659; Cucumis sativus (Cucumber).
OH NCBI_TaxID=3663; Cucurbita pepo (Vegetable marrow) (Summer squash).
OH NCBI_TaxID=3847; Glycine max (Soybean) (Glycine hispida).
OH NCBI_TaxID=4232; Helianthus annuus (Common sunflower).
OH NCBI_TaxID=4236; Lactuca sativa (Garden lettuce).
OH NCBI_TaxID=103529; Phlox drummondii (Annual phlox).
OH NCBI_TaxID=3888; Pisum sativum (Garden pea).
OH NCBI_TaxID=3726; Raphanus sativus (Radish) (Raphanus raphanistrum var. sativus).
OH NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH NCBI_TaxID=3562; Spinacia oleracea (Spinach).
OH NCBI_TaxID=3900; Trifolium subterraneum (Subterranean clover).
OH NCBI_TaxID=3906; Vicia faba (Broad bean) (Faba vulgaris).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RA Schubert J., Rabenstein F., Graichen K., Richter K.;
RT "Comparison of the 5'-end nucleotide sequences of luteoviruses from oilseed
RT rape and sugar beet.";
RL Arch. Phytopathol. Plant Prot. 31:519-530(1998).
CC -!- FUNCTION: Suppressor of RNA-mediated gene silencing, also known as
CC post-transcriptional gene silencing (PTGS), a mechanism of plant viral
CC defense that limits the accumulation of viral RNAs. The P0 protein
CC suppresses local PTGS using its F-box-like domain to mediate
CC destabilization and degradation of the AGO1 protein (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts (via F-box-like domain) with host AGO1; this
CC interaction targets AGO1 for degradation, and thereby suppresses the
CC silencing function of the latter. Interacts (via F-box-like domain)
CC with host ASK1 and ASK2 (SKP proteins); these interactions are
CC essential for viral pathogenicity. Part of a SCF P0 complex composed of
CC P0 and the host proteins SKP and CUL1 (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the polerovirus P0 protein family.
CC {ECO:0000305}.
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DR EMBL; Y16870; CAB40643.1; -; Genomic_RNA.
DR GO; GO:0016032; P:viral process; IEA:InterPro.
DR InterPro; IPR006755; Virus_P0.
DR Pfam; PF04662; Luteo_PO; 1.
PE 3: Inferred from homology;
KW Host-virus interaction; Suppressor of RNA silencing.
FT CHAIN 1..>218
FT /note="Suppressor of silencing P0"
FT /id="PRO_0000390911"
FT DOMAIN 63..67
FT /note="F-box-like"
FT NON_TER 218
SQ SEQUENCE 218 AA; 25366 MW; A0F114EDA0D5681B CRC64;
MQFVAHDNFH TLEVRKVRYL HSRQVTFLLA GLLLNIEQFV KAIKERNNEF KIDIFLRSLL
YQLPLHLGDH VHDDVRKSLL VPEPELCAWF SLQTGYAPAS TSGRVNLYVP GTKTSRRRII
QRSLASNFSE KFKRFPECLF VGFEHFQRFL SIWTRDAERR LFSGCREIPV GSHTLVELAN
LGELLRVMVA SEQFHNSRLL SRLAVHCYKI YGEDGFIS
