ID   P0_PLRVW                Reviewed;         247 AA.
AC   P11621;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Suppressor of silencing P0;
DE   AltName: Full=28 kDa protein;
DE   AltName: Full=Protein ORF0;
GN   ORFNames=ORF0;
OS   Potato leafroll virus (strain Potato/Netherlands/Wageningen/1989) (PLrV).
OC   Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC   Sobelivirales; Solemoviridae; Polerovirus.
OX   NCBI_TaxID=12048;
OH   NCBI_TaxID=4113; Solanum tuberosum (Potato).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2466700; DOI=10.1016/0014-5793(89)80190-5;
RA   van der Wilk F., Huisman M.J., Cornelissen B.J.C., Huttinga H.,
RA   Goldbach R.W.;
RT   "Nucleotide sequence and organization of potato leafroll virus genomic
RT   RNA.";
RL   FEBS Lett. 245:51-56(1989).
CC   -!- FUNCTION: Suppressor of RNA-mediated gene silencing, also known as
CC       post-transcriptional gene silencing (PTGS), a mechanism of plant viral
CC       defense that limits the accumulation of viral RNAs. The P0 protein
CC       suppresses local PTGS using its F-box-like domain to mediate
CC       destabilization and degradation of the AGO1 protein, although not via
CC       an interaction with host SKP1A. Participates, together with the
CC       proteins P1 and P7, in the inhibition of the induction of aphid-induced
CC       host phytohormones. This could play a role in the attraction to the
CC       infected plants by aphids. {ECO:0000250|UniProtKB:P17518}.
CC   -!- DOMAIN: The F-box-like domain is required for suppression of host RNA
CC       silencing. {ECO:0000250|UniProtKB:P17518}.
CC   -!- SIMILARITY: Belongs to the polerovirus P0 protein family.
CC       {ECO:0000305}.
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DR   EMBL; Y07496; CAA68794.1; -; Genomic_RNA.
DR   PIR; S03546; S03546.
DR   Proteomes; UP000000474; Genome.
DR   GO; GO:0016032; P:viral process; IEA:InterPro.
DR   InterPro; IPR006755; Virus_P0.
DR   Pfam; PF04662; Luteo_PO; 1.
PE   3: Inferred from homology;
KW   Host-virus interaction; Suppressor of RNA silencing.
FT   CHAIN           1..247
FT                   /note="Suppressor of silencing P0"
FT                   /id="PRO_0000222394"
FT   DOMAIN          76..95
FT                   /note="F-box-like"
FT                   /evidence="ECO:0000250|UniProtKB:P17518"
SQ   SEQUENCE   247 AA;  28129 MW;  D730FB2728482D56 CRC64;
     MIVLTQSGTL LFDQRFKLSK FLFVVIATGF PLLLQQASLI YGYNHEQIYR ICRSFLYILP
     LLNCKRGRIS TSGLQLPRHL HYECLEWGLL CGTHPAIQIV GPTIVIKLDD PTTAAAYRSE
     LLRVSSSSYI QNAAGLSNGW GHDMEAFVRN AICLLELRER SIPQSGLRDL MGNHQHLVRS
     LLDACKVDHF VPLDFQHRSL MLNFARLYNQ LDLQGRAKSF RALTGFPVYV PSEDYLEGSF
     LQKELQE