ID   P100_HHV6U              Reviewed;         870 AA.
AC   Q00701;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   02-JUN-2021, entry version 71.
DE   RecName: Full=Large structural phosphoprotein;
DE   AltName: Full=100 kDa phosphoprotein;
DE            Short=pp100;
DE   AltName: Full=Major antigenic structural protein;
GN   Name=U11; Synonyms=P1LF1;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1374813; DOI=10.1128/jvi.66.6.3918-3924.1992;
RA   Neipel F., Ellinger K., Fleckenstein B.;
RT   "Gene for the major antigenic structural protein (p100) of human
RT   herpesvirus 6.";
RL   J. Virol. 66:3918-3924(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8289364; DOI=10.1128/jvi.68.2.597-610.1994;
RA   Nicholas J., Martin M.E.D.;
RT   "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the genome
RT   of human herpesvirus 6 encoding human cytomegalovirus immediate-early gene
RT   homologs and transactivating functions.";
RL   J. Virol. 68:597-610(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000305}. Note=Also found in
CC       dense bodies. {ECO:0000250}.
CC   -!- PTM: Phosphorylated at multiple sites. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae large structural
CC       phosphoprotein family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA16716.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M87287; AAA46012.1; -; Genomic_DNA.
DR   EMBL; L25528; AAA16716.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X83413; CAA58438.1; -; Genomic_DNA.
DR   PIR; T09303; XPBE12.
DR   RefSeq; NP_042902.1; NC_001664.2.
DR   SMR; Q00701; -.
DR   PRIDE; Q00701; -.
DR   DNASU; 1487891; -.
DR   GeneID; 1487891; -.
DR   KEGG; vg:1487891; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR010340; Herpes_UL11/UL32.
DR   Pfam; PF06070; Herpes_UL32; 2.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..870
FT                   /note="Large structural phosphoprotein"
FT                   /id="PRO_0000116300"
FT   REGION          612..662
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          840..870
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        612..652
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   870 AA;  97072 MW;  F25954DEA19BF824 CRC64;
     MDLQRHPIPF AWLDRDKVER LTDFLSNLER LDNVDLREHP HVTNSCVVRE GDDVDDLKTL
     YNLLVLWLMY HYVLSKRKPD YNAIWQDITK LQSVVNEYLN SKGLNKGIFE NMFTNKEKFE
     SQFSDINRAL LRLGNFIKWG SNVAIDTPYV NLTAEDSSEI ENNLQDAEKN MLWYTVYNIN
     DPWDENGYLI TSINKLIYLG KLFLALTQSW SKLEKVAMSQ IVITQNHLSG HLRRHDNFNI
     VYSHRVLQTP LTGQRVESFL KIITSDYDII KSSLESHSAS KAFSMSEIGP NSLMDFVPLR
     GDIHSNLTLP SMSIDTKKSS LDPARLKKSN SRSLDSFLRM QRQPKFLELD SVDNAGEKIL
     LKEATLGGEN VKATTPASSV SLMSGVESPS SFTSTNLDLP LSSFTSTNLD LRDKSHGNYK
     IGPSGILDFN VKFPPNAQLN TNGVDLLQDK TSIGSPSSGI TDVVNGFANL NLHQNKSNVS
     PPWSRNTAAN ADFLDPVHRF VPEQTGTPFV LNNSDVAGSE AKHTTYSTET GVSPRNVFLI
     KDLRGKDGFR KQKQSDIPKS LTKERNDKAI MHSREVTGDS GDATETVGAR NSPALRKIKQ
     ANDFFAGLNK KNDRDVLRGG KGNSKDLHSG GNAKKKEMSG KFNDDKEMTR NGQEPSRSLM
     GDARNAGDEQ YIQAGLGQRV NNLLSQFTNL ISLGEKGIED ILQNQRGTEL KLATENKSGR
     ESEEANVEKI LEVSNPQDMF KNFRLQNDLD SVQSPFRLPD ADLSRELDSA SFKDALDLKL
     PGNGEREIDL ALEKVKVGET ETSDLKVGQD ESFVPAQLMK VETPEEKDDI IEQMVLRIRQ
     DGETDENTVS GPGVAESLDI EAKGESAIAS