ID   P100_HHV6Z              Reviewed;         858 AA.
AC   Q69535; Q785N5;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   02-JUN-2021, entry version 57.
DE   RecName: Full=Large structural phosphoprotein;
DE   AltName: Full=100 kDa phosphoprotein;
DE            Short=pp100;
DE   AltName: Full=Major antigenic structural protein;
GN   Name=U11;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HST;
RX   PubMed=10482554; DOI=10.1128/jvi.73.10.8053-8063.1999;
RA   Isegawa Y., Mukai T., Nakano K., Kagawa M., Chen J., Mori Y., Sunagawa T.,
RA   Kawanishi K., Sashihara J., Hata A., Zou P., Kosuge H., Yamanishi K.;
RT   "Comparison of the complete DNA sequences of human herpesvirus 6 variants A
RT   and B.";
RL   J. Virol. 73:8053-8063(1999).
CC   -!- SUBCELLULAR LOCATION: Virion tegument {ECO:0000305}. Note=Also found in
CC       dense bodies. {ECO:0000250}.
CC   -!- PTM: Phosphorylated at multiple sites. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae large structural
CC       phosphoprotein family. {ECO:0000305}.
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DR   EMBL; AF157706; AAA02870.1; -; Genomic_DNA.
DR   EMBL; AB021506; BAA78231.1; -; Genomic_DNA.
DR   PIR; T43970; T43970.
DR   RefSeq; NP_050192.1; NC_000898.1.
DR   PDB; 6Q1F; EM; 9.00 A; e/f/g/h/i/j/k/l/m/n/o/p=1-858.
DR   PDBsum; 6Q1F; -.
DR   SMR; Q69535; -.
DR   PRIDE; Q69535; -.
DR   GeneID; 1497011; -.
DR   KEGG; vg:1497011; -.
DR   Proteomes; UP000006930; Genome.
DR   Proteomes; UP000142685; Genome.
DR   GO; GO:0019033; C:viral tegument; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR010340; Herpes_UL11/UL32.
DR   Pfam; PF06070; Herpes_UL32; 3.
PE   1: Evidence at protein level;
KW   3D-structure; Phosphoprotein; Reference proteome; Virion; Virion tegument.
FT   CHAIN           1..858
FT                   /note="Large structural phosphoprotein"
FT                   /id="PRO_0000408409"
FT   REGION          603..629
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   858 AA;  95615 MW;  A3B37880F2D02B70 CRC64;
     MDLKAQSIPF AWLDRDKVQR LTNFLSNLEN LENVDLREHP YVTNSCVVRE GEDVDELKTL
     YNTFILWLMY HYVLSKRKPD YNAIWQDITK LQNVVNEYLK SKGLNKGNFE NMFTNKEKFE
     SQFSDIHRAL LRLGNSIRWG SNVPIDTPYV NLTAEDSSEI ENNLQDAEKN MLWYTVYNIN
     DPWDENGYLV TSINKLVYLG KLFVTLNQSW SKLEKVAMSQ IVTTQNHLSG HLRKNENFNA
     VYSQRVLQTP LTGQRVESFL KIITSDYEII KSSLESYSAS KAFSVPENGP HSLMDFASLD
     GRMPSDLSLP SISIDTKRPS ADLARLKISQ PKSLDAPLKT QRRHKFPESD SVDNAGGKIL
     IKKETLGGRD VRATTPVSSV SLMSGVEPLS SLTSTNLDLR DKSHGNYRIG PSGILDFGVK
     LPAEAQSNTG DVDLLQDKTS IRSPSSGITD VVNGLANLNL RQNKSDVSRP WSKNTAANAD
     VFDPVHRLVS EQTGTPFVLN NSDVAGSEAK LTTHSTETGV SPHNVSLIKD LRDKDGFRKQ
     KKLDLLGSWT KEKNDKAIVH SREVTGDSGD ATETVTARDS PVLRKTKHAN DIFAGLNKKY
     ARDVSRGGKG NSRDLYSGGN AEKKETSGKF NVDKEMTQNE QEPLPNLMEA ARNAGEEQYV
     QAGLGQRVNK ILAEFTNLIS LGEKGIQDIL HNQSGTELKL PTENKLGRES EEANVERILE
     VSDPQNLFKN FKLQNDLDSV QSPFRLPNAD LSRDLDSVSF KDALDVKLPG NGEREIDLAL
     QKVKAGERET SDFKVGQDET LIPTQLMKVE TPEEKDDVIE KMVLRIRQDG ETDEETVPGP
     GVAESLGIAA KDKSVIAS