P121B_HUMAN
ID P121B_HUMAN Reviewed; 834 AA.
AC A6NF01;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Putative nuclear envelope pore membrane protein POM 121B;
GN Name=POM121B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
CC -!- FUNCTION: Putative component of the nuclear pore complex (NPC). The
CC repeat-containing domain may be involved in anchoring components of the
CC pore complex to the pore membrane (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250}.
CC -!- DOMAIN: Contains F-X-F-G repeats. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the POM121 family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC073841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A6NF01; -.
DR IntAct; A6NF01; 4.
DR TCDB; 1.I.1.1.3; the nuclear pore complex (npc) family.
DR GlyGen; A6NF01; 6 sites, 1 O-linked glycan (6 sites).
DR iPTMnet; A6NF01; -.
DR PhosphoSitePlus; A6NF01; -.
DR BioMuta; HGNC:34004; -.
DR jPOST; A6NF01; -.
DR MassIVE; A6NF01; -.
DR MaxQB; A6NF01; -.
DR PeptideAtlas; A6NF01; -.
DR PRIDE; A6NF01; -.
DR ProteomicsDB; 1019; -.
DR GeneCards; POM121B; -.
DR HGNC; HGNC:34004; POM121B.
DR neXtProt; NX_A6NF01; -.
DR InParanoid; A6NF01; -.
DR SignaLink; A6NF01; -.
DR ChiTaRS; POM121B; human.
DR Pharos; A6NF01; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A6NF01; protein.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR InterPro; IPR026054; Nucleoporin.
DR InterPro; IPR026090; POM121.
DR PANTHER; PTHR23193; PTHR23193; 1.
DR PANTHER; PTHR23193:SF43; PTHR23193:SF43; 1.
PE 5: Uncertain;
KW mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Repeat; Translocation; Transport.
FT CHAIN 1..834
FT /note="Putative nuclear envelope pore membrane protein POM
FT 121B"
FT /id="PRO_0000346774"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 138..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..305
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 834 AA; 83015 MW; 3063DC34DD83F5B5 CRC64;
MSRRVRTSEL WKRNGPSSSP FSSPASSRSQ TPERPAKKIR EEEMCHHSSS STPLAADKES
QGEKAADTTP RKKQNSNSQS TPGSSGQRKR KVQLLPSRRG EQLTLPPPPQ LGYSITAEDL
DLEKKASLQW FNQALEDKSD AASNSVTETP PITQPSFTFT LPAAAPASPP TSLLAPSTNP
LLESLKKMQT PPSLPPCPES AGAATTEALS PPKTPNLLPP LGLSQSGPPG LLPSPSFDSN
PPTTLLGLIP APSMVPATDT KAPPTLQAET TTKPQATSAP SPAPKQSFLF GTQNTSPSSP
AAPAASSASP MFKPIFTAPP KSEKEGPTPP GPSVSATAPS SSSLPTTTST TAPTFQPVFS
SMGPPASVPL PAPFFKQTTT PATAPTTTAP LFTGLASATS AVAPITSASP STDSASKPAF
GFGINSVSSS SVSTTTSTAT AASQPFLFGA PQASAASFTP AMGSIFQFGK PPALPTTTTV
TTFSQSLPTA VPTATSSSAA DFSGFGSTLA TSAPATSSQP TLTFSNTSTP TFNIPFGSSA
KSPLPSYPGA NPQPAFGAAE GQPPGAAKPA LTPSFGSSFT FGNSAAPAAA PTPAPPSMIK
IVPAHVPTPI QPTFGGATHS AFGLKATASA FGAPASSQPA FGGSTAVFSF GAATSSGFGA
TTQTASSGSS SSVFGSTTPS PFTFGGSAAP AGSGSFGINV ATPGSSATTG AFSFGAGQSG
STATSTPFAG GLGQNALGTT GQSTPFAFNV GSTTESKPVF GGTATPTFGL NTPAPGVGTS
GSSLSFGASS APAQGFVGVA PFGSAAPSFS IGAGSKTLGA RQRLQARRQH TRKK
