P12L2_HUMAN
ID P12L2_HUMAN Reviewed; 1035 AA.
AC Q96KW2; C9J1I7;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=POM121-like protein 2;
GN Name=POM121L2; Synonyms=POM121L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
CC -!- SIMILARITY: Belongs to the POM121 family. {ECO:0000305}.
CC -!- CAUTION: This sequence lacks full-length transcript support.
CC {ECO:0000305}.
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DR EMBL; AL021808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS59497.1; -.
DR RefSeq; NP_258443.2; NM_033482.3.
DR AlphaFoldDB; Q96KW2; -.
DR IntAct; Q96KW2; 1.
DR STRING; 9606.ENSP00000392726; -.
DR GlyGen; Q96KW2; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96KW2; -.
DR PhosphoSitePlus; Q96KW2; -.
DR BioMuta; POM121L2; -.
DR DMDM; 74751990; -.
DR EPD; Q96KW2; -.
DR MassIVE; Q96KW2; -.
DR PaxDb; Q96KW2; -.
DR PeptideAtlas; Q96KW2; -.
DR PRIDE; Q96KW2; -.
DR ProteomicsDB; 77125; -.
DR ProteomicsDB; 8090; -.
DR Antibodypedia; 49628; 7 antibodies from 6 providers.
DR DNASU; 94026; -.
DR Ensembl; ENST00000444565.2; ENSP00000392726.1; ENSG00000158553.5.
DR GeneID; 94026; -.
DR KEGG; hsa:94026; -.
DR MANE-Select; ENST00000444565.2; ENSP00000392726.1; NM_033482.4; NP_258443.2.
DR UCSC; uc011dku.2; human.
DR CTD; 94026; -.
DR DisGeNET; 94026; -.
DR GeneCards; POM121L2; -.
DR HGNC; HGNC:13973; POM121L2.
DR HPA; ENSG00000158553; Tissue enriched (testis).
DR neXtProt; NX_Q96KW2; -.
DR OpenTargets; ENSG00000158553; -.
DR PharmGKB; PA33524; -.
DR VEuPathDB; HostDB:ENSG00000158553; -.
DR eggNOG; ENOG502RWWZ; Eukaryota.
DR GeneTree; ENSGT00940000153253; -.
DR HOGENOM; CLU_011366_0_1_1; -.
DR InParanoid; Q96KW2; -.
DR OMA; TIWSLRH; -.
DR OrthoDB; 355024at2759; -.
DR PhylomeDB; Q96KW2; -.
DR TreeFam; TF350673; -.
DR PathwayCommons; Q96KW2; -.
DR BioGRID-ORCS; 94026; 4 hits in 1053 CRISPR screens.
DR ChiTaRS; POM121L2; human.
DR GenomeRNAi; 94026; -.
DR Pharos; Q96KW2; Tdark.
DR PRO; PR:Q96KW2; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q96KW2; protein.
DR Bgee; ENSG00000158553; Expressed in left testis and 12 other tissues.
DR ExpressionAtlas; Q96KW2; baseline and differential.
DR Genevisible; Q96KW2; HS.
DR GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR InterPro; IPR026054; Nucleoporin.
DR PANTHER; PTHR23193; PTHR23193; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..1035
FT /note="POM121-like protein 2"
FT /id="PRO_0000292039"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 972..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..192
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..503
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1001..1016
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1035
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1035 AA; 109912 MW; 31DC5E1160B21E5A CRC64;
MGSFLSKLEL SPSSPAQVRT DLPERPTKRR PPQPLHQVHR VQFVHRAHPA PRYRPVRRRP
NLDPANPTTW LANEAWRRFP MKKSQNSPLG PLPSDWWESY LKRTIWSLRH PRPIWSPVTI
RITPPDQRVP PSTSPEDVIA LAGLPPSEEL ADPCSKETVL RALRECRKGK GRLEEPLFPE
SLDSKRRSPE TRPSAFKPLM KNGTLTSFVP RPGPLKRSLH SWGSDHSLTK RPNCSSMSSL
ASIYRGGTLS SKRNAIGSSY SSCRNFSDPW KRSVPSVSFE TPEWPIKKEK SCHRPSSPVP
LVSDFESLGG SESSGQQNQK IPQLPSSPEN LVSEIPPPQL GYAVSDENLT LGKKAELQVS
NNAGEDTTEV NTDPFPETWL AIQPSLSLAL PSSETDLTQG ANPQLENLRK MQKSLGPLAS
PQSTGEATSV AHSPLKTPSL PTPPGCSQSE LLPGTSPDSK PTATFILLTP TSPTLPVTDT
TWPPSTSQAD RSPMPPDPPA PPTIQSTLLG MVSSPTSHLS ASAPPDATSA HLMLKPILGP
LHNSEIGSSS YSRISVTAAA SSISSLSTIQ GTLTPTFKPI FGSIDPLKTT PMIAPFSSKQ
TPPPFTHAST HHFHGLVKAT SVVMSTTLAS TSKDSVFKPP LDFGVVNVTS AVGNTYSVPS
TCDTFLLGTA QAFRADFTPA TGFIFPPHHH PTIPTVHTVT MFTQVLSSVV QISPRSSTAN
FRGMGSPLPA SALVSTNWLA STPSISNLTP AITSPLGSSS RPPFPLSQGA NPQPAFGATN
GQKQGPSQPA LMPSVSSSFL FGSSAVALPT PMPTPAQPAF ISTTQSALGC LTPSASTSQT
PASTWSGIGG IPAGFPISQA STTGFRIVIQ THQSGAFGSV FGSRAPQPFT FGGFVTPMDC
DESGIIMTGP DMSPTSGAFS IGALPSGTTN TMIPFGKGWS QNTEGLPSHR TAFSLGRGSI
SARKTMAPIA QNTPVPGQAK AGSSVGFGMP FPPAQGSVGR GPFRSSASSF SIGAKSKTPK
NREKGHSRRH HAYKK
