ID   P12L2_MOUSE             Reviewed;         972 AA.
AC   Q5SW25;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=POM121-like protein 2;
GN   Name=Pom121l2; Synonyms=Gm24;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SIMILARITY: Belongs to the POM121 family. {ECO:0000305}.
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DR   EMBL; AL606968; CAI24930.1; -; Genomic_DNA.
DR   EMBL; AL589879; CAI24930.1; JOINED; Genomic_DNA.
DR   EMBL; AL589879; CAI25473.1; -; Genomic_DNA.
DR   EMBL; AL606968; CAI25473.1; JOINED; Genomic_DNA.
DR   CCDS; CCDS49217.1; -.
DR   RefSeq; NP_001156400.1; NM_001162928.1.
DR   AlphaFoldDB; Q5SW25; -.
DR   STRING; 10090.ENSMUSP00000017126; -.
DR   PhosphoSitePlus; Q5SW25; -.
DR   PaxDb; Q5SW25; -.
DR   PRIDE; Q5SW25; -.
DR   ProteomicsDB; 293940; -.
DR   Antibodypedia; 49628; 7 antibodies from 6 providers.
DR   Ensembl; ENSMUST00000017126; ENSMUSP00000017126; ENSMUSG00000016982.
DR   GeneID; 195236; -.
DR   KEGG; mmu:195236; -.
DR   UCSC; uc011ywx.1; mouse.
DR   CTD; 94026; -.
DR   MGI; MGI:2684870; Pom121l2.
DR   VEuPathDB; HostDB:ENSMUSG00000016982; -.
DR   eggNOG; ENOG502RWWZ; Eukaryota.
DR   GeneTree; ENSGT00940000153253; -.
DR   HOGENOM; CLU_011366_0_1_1; -.
DR   InParanoid; Q5SW25; -.
DR   OMA; TIWSLRH; -.
DR   OrthoDB; 355024at2759; -.
DR   PhylomeDB; Q5SW25; -.
DR   TreeFam; TF350673; -.
DR   BioGRID-ORCS; 195236; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Pom121l2; mouse.
DR   PRO; PR:Q5SW25; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; Q5SW25; protein.
DR   Bgee; ENSMUSG00000016982; Expressed in seminiferous tubule of testis and 4 other tissues.
DR   ExpressionAtlas; Q5SW25; baseline and differential.
DR   Genevisible; Q5SW25; MM.
DR   GO; GO:0005643; C:nuclear pore; IBA:GO_Central.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR   GO; GO:0017056; F:structural constituent of nuclear pore; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   GO; GO:0006405; P:RNA export from nucleus; IBA:GO_Central.
DR   InterPro; IPR026054; Nucleoporin.
DR   PANTHER; PTHR23193; PTHR23193; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..972
FT                   /note="POM121-like protein 2"
FT                   /id="PRO_0000292040"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          328..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          406..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          676..726
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          953..972
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..302
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        335..352
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   972 AA;  103220 MW;  BA3929B844B099F7 CRC64;
     MGSYLGKAGS SPRSPAQGRA DSGEKPASRR PARPLYQVHR VQHVHRAQPA RRHRPARRPP
     NWDPANPTAF VSEAWRRFPM KRPQNPIMGS LPSDWWESYL KRNIWSLRHP RATWSPVTVK
     ISPPERRPRP LFPVSRVVNS AGPSEEPPGP CGKDPVLRAL LQCRKGRARW EEPLFPDTSD
     SQRHSASVWS AFKPLLKSGA TVSFVARPGS LKRRPHVQSS DDKCKRSGCF SGALVASIHT
     QGPPSTKRNA ITSSYSSSRE LSGSWKRHFL RTLVQTPEWP LKKAGESPNS HLSVTPSSSG
     QLNGEIPLLQ SGPRDLLTIP CQQGPVVTEE DPTLEGQAVP SNQTTEATTG TAGDSIPEMR
     AGIQPTLSLS RSSSERVLST HVNPQLESLK NMPAPLGCSQ LEHIQGISSD SNPSIASTQA
     SPSSPTTPVT DSTWLSSIPR AHRSAVPPHS SVINPTAPTT QSTLVGVVSN PILHLPASVL
     PVETSSHLAL RPIWGPVHST EVRTASYSRI SVMAEASSSS SPSTTPGILR PTFKPIFGSI
     EPLQTMSETA PVHTRQPSSS LSSDSTHLFH SLATTAPCVV TSVIPASKSK DPGVDLNIVT
     STTGNSCSVP SCSTFLLGAS QNFPSATDLI FPSQHPTIPT VHTVTIFSQV LTSAIKISPL
     RSTDTLKGVS NPLATLGLSS TNQPPVTSSN SNVTSALTSS LGSSPKPLLP PSQRNTSQSS
     PGAIDGLKQS SLQLAPAQSF STSFLSENSG VSPTPSAQLV LSKTTQPACG QLTSSAPIIH
     TPATSQTGFG STLAGFPFGK ASSTALRVIR QNHQSVTYSS VFGSTAPRPF AFGGLVMPMD
     CGEPEVIVAA PKRSTSGTRQ SMTPSTLAPF VQCWNQSMQG PPNQITPLAG IPARKIMSGA
     PSLVPFAQSI PVPGAIKAGS SLGFGMSSPT VQGSVGRNPL RSLEPSFCIG TKSKTLRNRE
     PGRSRKHHTY KK