P12LL_HUMAN
ID P12LL_HUMAN Reviewed; 897 AA.
AC A6NNC1; A6NNK7; Q8N834;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 3.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Putative POM121-like protein 1-like;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-75.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 237-897.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 566-645.
RC TISSUE=Spinal cord;
RX PubMed=7818533; DOI=10.1006/bbrc.1995.1041;
RA Pizzuti A., Colosimo A., Ratti A., Capon F., Gennarelli M., Silani V.,
RA Ghezzi C., Lo Cicero S., Calabrese G., Palka G., Scarlato G., Novelli G.,
RA Dallapiccola B.;
RT "Identification of multiple transcribed sequences from the spinal muscular
RT atrophy region of human chromosome 5.";
RL Biochem. Biophys. Res. Commun. 206:294-301(1995).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 736-832.
RC TISSUE=Fetal brain;
RX PubMed=8764824; DOI=10.1016/0167-4781(96)00097-8;
RA Morrison K.E., Qureshi S.J., Anderson S., Borrett J.P., Theodosiou A.,
RA Rodrigues N., Blake D., Nesbit A., Davies K.E., Porteous D.J.,
RA Brookes A.J.;
RT "Novel transcribed sequences represented in the complex genomic region
RT 5q13.";
RL Biochim. Biophys. Acta 1308:97-102(1996).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the POM121 family. {ECO:0000305}.
CC -!- CAUTION: Product of a dubious CDS prediction. {ECO:0000305}.
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DR EMBL; AC139272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC051369; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK097411; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; L40517; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; Z70704; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; A6NNC1; -.
DR SMR; A6NNC1; -.
DR iPTMnet; A6NNC1; -.
DR PhosphoSitePlus; A6NNC1; -.
DR BioMuta; -; -.
DR MassIVE; A6NNC1; -.
DR PeptideAtlas; A6NNC1; -.
DR PRIDE; A6NNC1; -.
DR neXtProt; NX_A6NNC1; -.
DR PhylomeDB; A6NNC1; -.
DR Pharos; A6NNC1; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A6NNC1; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR043220; POM121-like_prot_1.
DR PANTHER; PTHR15566; PTHR15566; 3.
PE 5: Uncertain;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..897
FT /note="Putative POM121-like protein 1-like"
FT /id="PRO_0000346775"
FT TRANSMEM 877..897
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 484..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 536..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 75
FT /note="S -> N (in Ref. 2; BC051369)"
FT /evidence="ECO:0000305"
FT CONFLICT 678
FT /note="Q -> R (in Ref. 3; AK097411)"
FT /evidence="ECO:0000305"
FT CONFLICT 680
FT /note="L -> V (in Ref. 3; AK097411)"
FT /evidence="ECO:0000305"
FT CONFLICT 733
FT /note="Y -> S (in Ref. 3; AK097411)"
FT /evidence="ECO:0000305"
FT CONFLICT 752
FT /note="K -> N (in Ref. 5; Z70704)"
FT /evidence="ECO:0000305"
FT CONFLICT 811
FT /note="S -> F (in Ref. 3; AK097411 and 5; Z70704)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 897 AA; 94058 MW; 88E4CF87C24A12CF CRC64;
MPEQDKDPRV QENPDDQRTV PEVTGDARSA FWPLRDNGGP SPFVPRPGPL QTDLHAQSSE
IRYNHTSQTS WTSSSTKRNA ISSSYSSTGG LPGLKQRRGP ASSRCQLTLS YSKTVSEDRP
QAVSSGHTRC EKGADTAPGQ TIAPTGGSPR SQDSRPRRRK IPLLPRRRGE PLMLPPPLEL
GYRVTAEDLH LEKETAFQRI NSALHVEDKA IPDCRPSRPS HTLSSLATGA SGGPPVSKAP
TMDAQQDRPK SQDSLGLLAP LASAAEVPST APVSGKKHRP PGPLFSSSDP LPATSYHSRD
TAQVTSLIPA TFTAASRDAG MRRTRSAPAA ATAAPPPSTL NNTSGSLLNA VDGGPSHFLA
SATAAARAQR SEVRYNQRSQ TSRTRSCLKR NASSSSSSHS STEGLQELKR RRGPASSHCQ
LAHSSSNTVS EDGPQAVSSG HRCENKAGTA PGQTLAPRGG SPRSQASRPH INSALYVEDK
AISDCRPSRP SHTLSSLATG ASGGPPVSKA PTMDAQQDRP KSQDCLGLVA PLASAAEVPS
TAPVSGKKHR PPGPLFSSSD PLPATSSHSR DSAQVTSLIP ATFTAASRDA GMRRTRPGTS
APAAAAAALP PSTLNPTSGS LLNAVDGGPS HFLASATAAA RAQRSEVRYN QRSQTSRTRS
CLKRNASSSS HSSTEGLQEL KRRRGPASSH CQLAHSSSNT VSEDGPQAVS SGHRCENKAG
TAPGQTLAPR GGYPRSQASR PRINSALHVE DKAISDCRPS RPSHTLSSLA TGASGGPPVS
KAPTMDAQQD RPKSQDCLGL LAPLASAAEV SSTAPVSGKK HRPPGPLFSS SDPLPATSSH
SGDSAQDTSL IPAPFTPASR DAGIRRMFRV RNCLRGLGLF LLVFSFFFLL TWASFSF
