ID   P12_BPPM2               Reviewed;         634 AA.
AC   Q9XJS3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Probable replication protein P12;
DE            EC=3.1.-.-;
DE   AltName: Full=Protein XII;
GN   Name=XII;
OS   Pseudoalteromonas phage PM2 (Bacteriophage PM2).
OC   Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes;
OC   Vinavirales; Corticoviridae; Corticovirus.
OX   NCBI_TaxID=10661;
OH   NCBI_TaxID=28107; Pseudoalteromonas espejiana.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10502514; DOI=10.1006/viro.1999.9837;
RA   Maennistoe R.H., Kivelae H.M., Paulin L., Bamford D.H., Bamford J.K.;
RT   "The complete genome sequence of PM2, the first lipid-containing bacterial
RT   virus to be isolated.";
RL   Virology 262:355-363(1999).
CC   -!- FUNCTION: Probable endonuclease which induces a single-strand cut and
CC       initiates DNA replication.
CC   -!- SIMILARITY: Belongs to the phage GPA family. {ECO:0000305}.
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DR   EMBL; AF155037; AAD43543.1; -; Genomic_DNA.
DR   RefSeq; NP_049896.1; NC_000867.1.
DR   PRIDE; Q9XJS3; -.
DR   GeneID; 1262037; -.
DR   KEGG; vg:1262037; -.
DR   Proteomes; UP000002136; Genome.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0039693; P:viral DNA genome replication; IEA:UniProtKB-KW.
DR   InterPro; IPR008766; Replication_gene_A.
DR   Pfam; PF05840; Phage_GPA; 1.
PE   3: Inferred from homology;
KW   DNA replication; Endonuclease; Hydrolase; Nuclease; Reference proteome;
KW   Viral DNA replication.
FT   CHAIN           1..634
FT                   /note="Probable replication protein P12"
FT                   /id="PRO_0000339907"
FT   ACT_SITE        410
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        414
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   634 AA;  72094 MW;  EC5CDD004FEB2506 CRC64;
     MRSIAIGHEP IKGGLKPIEL IRPVPFCSPA FGFDKAAEYA KEQLKKIPTT YLRRHAAKLY
     AARFNSTTAK NPEKSANIFM RELVKRVDQI VTRSPLNITE LQRDKRRKDK AKQLALICQQ
     MGIVDFDKSM TLEQATALVI SKYQKLAEFT INQIDTAPAY STYEAFMKKG GNPEILADKL
     EIAIRRMTCD KWWQRKLNRA RDMTLEHLNI TLGLVNKKKS PYASLQAVNE FKYAKKSQQK
     WLDSMQLESD DGETTLDLAE VFKGSVSNPE IRRVELMVRI RGYEEYAQEQ GMKAVFYTIT
     APSKYHANSK KYNNATPKET QAFLVNQWAK ARAELNKIDV PVFGVRVVEP HHDATPHWHM
     LLFMLPEHEQ VTTKALRGYA MQIDGDEKGA EQARFTAENI DPSKGSAVGY IAKYISKNIN
     ANHIEGEKDN ETGGEFNNEN GLVLNVGAWA SRWRIRQFQF VGGASVGVWR EIRRAKPEML
     DKSTDVLREI FSAADNSQFA QFINLMGGAF AKRSERPIQI SRVADGLNEY GEEKKRVVGL
     ESCSNVLKTR LMRFALKKRS DSDAPWSTEN NCNHPANDWQ IGAGDRLNPI AFIPKEIRNN
     VLRGATYYEV DEQLKTITEF KVKNNQLTQE SIGL