ID   ASF1L_CAEEL             Reviewed;         245 AA.
AC   Q17603;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 4.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Probable histone chaperone asf-1-like protein;
DE   AltName: Full=Anti-silencing function protein 1-like;
GN   Name=asfl-1; ORFNames=C03D6.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Histone chaperone that facilitates histone deposition and
CC       histone exchange and removal during nucleosome assembly and
CC       disassembly. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histone H3 and histone H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ASF1 family. {ECO:0000305}.
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DR   EMBL; Z75525; CAA99762.3; -; Genomic_DNA.
DR   PIR; T18882; T18882.
DR   RefSeq; NP_492567.3; NM_060166.5.
DR   AlphaFoldDB; Q17603; -.
DR   SMR; Q17603; -.
DR   BioGRID; 38236; 5.
DR   STRING; 6239.C03D6.5; -.
DR   EPD; Q17603; -.
DR   PaxDb; Q17603; -.
DR   PeptideAtlas; Q17603; -.
DR   EnsemblMetazoa; C03D6.5.1; C03D6.5.1; WBGene00007277.
DR   GeneID; 172812; -.
DR   KEGG; cel:CELE_C03D6.5; -.
DR   CTD; 172812; -.
DR   WormBase; C03D6.5; CE36095; WBGene00007277; asfl-1.
DR   eggNOG; KOG3265; Eukaryota.
DR   GeneTree; ENSGT00390000004692; -.
DR   HOGENOM; CLU_060354_0_1_1; -.
DR   InParanoid; Q17603; -.
DR   OMA; KINWDYG; -.
DR   OrthoDB; 1334998at2759; -.
DR   PhylomeDB; Q17603; -.
DR   PRO; PR:Q17603; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00007277; Expressed in adult organism and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IMP:UniProtKB.
DR   GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0016573; P:histone acetylation; IEA:InterPro.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0006337; P:nucleosome disassembly; IEA:InterPro.
DR   GO; GO:0048477; P:oogenesis; IMP:UniProtKB.
DR   GO; GO:0060378; P:regulation of brood size; IMP:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IMP:UniProtKB.
DR   Gene3D; 2.60.40.1490; -; 1.
DR   InterPro; IPR006818; ASF1-like.
DR   InterPro; IPR036747; ASF1-like_sf.
DR   InterPro; IPR017282; Hist_deposition_Asf1.
DR   PANTHER; PTHR12040; PTHR12040; 1.
DR   Pfam; PF04729; ASF1_hist_chap; 1.
DR   PIRSF; PIRSF037759; Histone_Asf1; 1.
DR   SUPFAM; SSF101546; SSF101546; 1.
PE   3: Inferred from homology;
KW   Chaperone; Chromatin regulator; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..245
FT                   /note="Probable histone chaperone asf-1-like protein"
FT                   /id="PRO_0000284024"
FT   REGION          157..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..202
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..245
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   245 AA;  27997 MW;  6FF82FA991C3DB50 CRC64;
     MASRVNIVQV QILDNPAMFV DKFKMEITFE VFEHLPHDLE WELVYVGSGT SRDFDQVLDS
     ALVGPIPEGR HKFVFDAEHP DISKIPVEDI VGVSVLLLRC KYNDQEFINM GWFVANEYTD
     EELKENPPAK PLIEKLSRKI ETEDLRVTTF PIRWTDEDPV AEPVDEEANK VFDEDDLMPL
     HDDGQDDDEE EEDDDETGPN TEEVDLNESF NERMANAHDG TEQKNGEESM EHDGASGDVE
     MGDKH