ASF1_ASHGO
ID ASF1_ASHGO Reviewed; 276 AA.
AC Q759F6;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2013, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Histone chaperone ASF1;
DE AltName: Full=Anti-silencing function protein 1;
GN Name=ASF1; OrderedLocusNames=ADR320C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION, AND SEQUENCE REVISION TO 62; 71-74; 138 AND 154-155.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Histone chaperone that facilitates histone deposition and
CC histone exchange and removal during nucleosome assembly and
CC disassembly. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with histone H3 and histone H4. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ASF1 family. {ECO:0000305}.
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DR EMBL; AE016817; AAS52240.2; -; Genomic_DNA.
DR RefSeq; NP_984416.2; NM_209769.2.
DR AlphaFoldDB; Q759F6; -.
DR SMR; Q759F6; -.
DR STRING; 33169.AAS52240; -.
DR EnsemblFungi; AAS52240; AAS52240; AGOS_ADR320C.
DR GeneID; 4620582; -.
DR KEGG; ago:AGOS_ADR320C; -.
DR eggNOG; KOG3265; Eukaryota.
DR HOGENOM; CLU_060354_0_2_1; -.
DR InParanoid; Q759F6; -.
DR OMA; SYDEREF; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:GOC.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0070775; C:H3 histone acetyltransferase complex; IEA:EnsemblFungi.
DR GO; GO:0010698; F:acetyltransferase activator activity; IEA:EnsemblFungi.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IBA:GO_Central.
DR GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR GO; GO:0043486; P:histone exchange; IEA:EnsemblFungi.
DR GO; GO:0033523; P:histone H2B ubiquitination; IEA:EnsemblFungi.
DR GO; GO:0097043; P:histone H3-K56 acetylation; IEA:EnsemblFungi.
DR GO; GO:0006334; P:nucleosome assembly; IEA:EnsemblFungi.
DR GO; GO:0006337; P:nucleosome disassembly; IEA:EnsemblFungi.
DR GO; GO:0035066; P:positive regulation of histone acetylation; IEA:EnsemblFungi.
DR GO; GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:EnsemblFungi.
DR GO; GO:0043618; P:regulation of transcription from RNA polymerase II promoter in response to stress; IEA:EnsemblFungi.
DR GO; GO:0030466; P:silent mating-type cassette heterochromatin assembly; IEA:EnsemblFungi.
DR GO; GO:0031509; P:subtelomeric heterochromatin assembly; IEA:EnsemblFungi.
DR Gene3D; 2.60.40.1490; -; 1.
DR InterPro; IPR006818; ASF1-like.
DR InterPro; IPR036747; ASF1-like_sf.
DR InterPro; IPR017282; Hist_deposition_Asf1.
DR PANTHER; PTHR12040; PTHR12040; 1.
DR Pfam; PF04729; ASF1_hist_chap; 1.
DR PIRSF; PIRSF037759; Histone_Asf1; 1.
DR SUPFAM; SSF101546; SSF101546; 1.
PE 3: Inferred from homology;
KW Chaperone; Chromatin regulator; Coiled coil; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..276
FT /note="Histone chaperone ASF1"
FT /id="PRO_0000284026"
FT REGION 151..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 202..243
FT /evidence="ECO:0000255"
FT COMPBIAS 157..196
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..257
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 276 AA; 30921 MW; EE4F9B35295B2AA6 CRC64;
MSIVSLLGVK VVNNPAKFTD PYEFEITFEC LEPLKHDLEW KLTYVGSSRS LEHDQELDSI
LVGPIPVGVN KFLFTADPPS AELIPASELV SVTVILLSCS YDGREFVRVG YYVNNEYDTE
ELRNDPPQKV QVDHVVRNIL AEKPRVTRFN IVWDNEAEDE YPPEQPGVDD EEVDDEDEDE
DEDEEGADEE GADEEGASDG PDAKKRKVQT EDEEDDEAEE IDLEAEEEED EDEEDEDGDE
AEEVDEEEED DDGEPVGASE GGADTVPTPQ DTTESK
