P15B_RABIT
ID P15B_RABIT Reviewed; 137 AA.
AC P26203;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 2.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=15 kDa protein B;
DE AltName: Full=P15H;
DE AltName: Full=Protein P15B;
DE Flags: Precursor;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=New Zealand white; TISSUE=Bone marrow;
RX PubMed=8449963; DOI=10.1016/s0021-9258(18)53425-6;
RA Levy O., Weiss J., Zarember K., Ooi C.E., Elsbach P.;
RT "Antibacterial 15-kDa protein isoforms (p15s) are members of a novel family
RT of leukocyte proteins.";
RL J. Biol. Chem. 268:6058-6063(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8273570; DOI=10.1007/bf01972768;
RA Levy O., Weiss J., Ooi C.E., Elsbach P.;
RT "Structural characterization of BPI-modulating 15 kDa proteins from rabbit
RT polymorphonuclear leukocytes: identification of a novel family of leukocyte
RT proteins.";
RL Agents Actions 39:C207-C210(1993).
RN [3]
RP PROTEIN SEQUENCE OF 21-40.
RC TISSUE=Neutrophil;
RX PubMed=2203792; DOI=10.1016/s0021-9258(18)55490-9;
RA Ooi C.E., Weiss J., Levy O., Elsbach P.;
RT "Isolation of two isoforms of a novel 15-kDa protein from rabbit
RT polymorphonuclear leukocytes that modulate the antibacterial actions of
RT other leukocyte proteins.";
RL J. Biol. Chem. 265:15956-15962(1990).
CC -!- FUNCTION: Binds to bacterial lipopolysaccharides (LPS), potentiates
CC weakly the early antibacterial effects of BPI. Inhibits the late lethal
CC action of BPI.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Large granules of neutrophils.
CC -!- SIMILARITY: Belongs to the cathelicidin family. {ECO:0000305}.
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DR EMBL; L07587; AAA99903.1; ALT_SEQ; mRNA.
DR EMBL; S68155; AAB29404.1; -; mRNA.
DR PIR; B46634; B46634.
DR AlphaFoldDB; P26203; -.
DR SMR; P26203; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR InterPro; IPR001894; Cathelicidin-like.
DR InterPro; IPR018216; Cathelicidin_CS.
DR InterPro; IPR046350; Cystatin_sf.
DR PANTHER; PTHR10206; PTHR10206; 1.
DR SUPFAM; SSF54403; SSF54403; 1.
DR PROSITE; PS00946; CATHELICIDINS_1; 1.
DR PROSITE; PS00947; CATHELICIDINS_2; 1.
PE 1: Evidence at protein level;
KW Antibiotic; Antimicrobial; Direct protein sequencing; Disulfide bond;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:2203792"
FT CHAIN 21..137
FT /note="15 kDa protein B"
FT /id="PRO_0000004757"
FT DISULFID 77..88
FT /evidence="ECO:0000250"
FT DISULFID 99..116
FT /evidence="ECO:0000250"
FT CONFLICT 39
FT /note="Y -> E (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 137 AA; 15626 MW; CD06B1FA139E79B2 CRC64;
MAGVWKVLVV LVGLAVVACA IPHRRLRYEE VVAQALQFYN EGQQGQPLFR LLEATPPPSL
NSKSRIPLNF RIKETVCIFT LDRQPGNCAF REGGEERICR GAFVRRRRVR ALTLRCDRDQ
RRQPEFPRVT RPAGPTA