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ASF1_ASPFU
ID   ASF1_ASPFU              Reviewed;         282 AA.
AC   Q4WXX5;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Histone chaperone asf1;
DE   AltName: Full=Anti-silencing function protein 1;
GN   Name=asf1; ORFNames=AFUA_3G11030;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Histone chaperone that facilitates histone deposition and
CC       histone exchange and removal during nucleosome assembly and
CC       disassembly. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with histone H3 and histone H4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ASF1 family. {ECO:0000305}.
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DR   EMBL; AAHF01000002; EAL92478.1; -; Genomic_DNA.
DR   RefSeq; XP_754516.1; XM_749423.1.
DR   PDB; 5ZBA; X-ray; 3.50 A; B=1-154.
DR   PDB; 5ZBB; X-ray; 3.60 A; B=1-154.
DR   PDBsum; 5ZBA; -.
DR   PDBsum; 5ZBB; -.
DR   AlphaFoldDB; Q4WXX5; -.
DR   SMR; Q4WXX5; -.
DR   STRING; 746128.CADAFUBP00003733; -.
DR   PRIDE; Q4WXX5; -.
DR   EnsemblFungi; EAL92478; EAL92478; AFUA_3G11030.
DR   GeneID; 3511719; -.
DR   KEGG; afm:AFUA_3G11030; -.
DR   VEuPathDB; FungiDB:Afu3g11030; -.
DR   eggNOG; KOG3265; Eukaryota.
DR   HOGENOM; CLU_060354_0_2_1; -.
DR   InParanoid; Q4WXX5; -.
DR   OMA; SYDEREF; -.
DR   OrthoDB; 1231087at2759; -.
DR   Proteomes; UP000002530; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006335; P:DNA replication-dependent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0006336; P:DNA replication-independent chromatin assembly; IBA:GO_Central.
DR   GO; GO:0016573; P:histone acetylation; IEA:InterPro.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0006337; P:nucleosome disassembly; IEA:InterPro.
DR   Gene3D; 2.60.40.1490; -; 1.
DR   InterPro; IPR006818; ASF1-like.
DR   InterPro; IPR036747; ASF1-like_sf.
DR   InterPro; IPR017282; Hist_deposition_Asf1.
DR   PANTHER; PTHR12040; PTHR12040; 1.
DR   Pfam; PF04729; ASF1_hist_chap; 1.
DR   PIRSF; PIRSF037759; Histone_Asf1; 1.
DR   SUPFAM; SSF101546; SSF101546; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Chaperone; Chromatin regulator; Coiled coil; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..282
FT                   /note="Histone chaperone asf1"
FT                   /id="PRO_0000284027"
FT   REGION          151..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          193..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          181..249
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        193..214
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..261
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          3..13
FT                   /evidence="ECO:0007829|PDB:5ZBA"
FT   STRAND          22..32
FT                   /evidence="ECO:0007829|PDB:5ZBA"
FT   STRAND          38..46
FT                   /evidence="ECO:0007829|PDB:5ZBA"
FT   STRAND          53..62
FT                   /evidence="ECO:0007829|PDB:5ZBA"
FT   STRAND          67..76
FT                   /evidence="ECO:0007829|PDB:5ZBA"
FT   HELIX           81..83
FT                   /evidence="ECO:0007829|PDB:5ZBA"
FT   TURN            86..89
FT                   /evidence="ECO:0007829|PDB:5ZBA"
FT   STRAND          90..101
FT                   /evidence="ECO:0007829|PDB:5ZBA"
FT   STRAND          104..119
FT                   /evidence="ECO:0007829|PDB:5ZBA"
FT   HELIX           120..124
FT                   /evidence="ECO:0007829|PDB:5ZBA"
FT   HELIX           132..134
FT                   /evidence="ECO:0007829|PDB:5ZBA"
FT   STRAND          135..139
FT                   /evidence="ECO:0007829|PDB:5ZBA"
FT   STRAND          145..148
FT                   /evidence="ECO:0007829|PDB:5ZBA"
SQ   SEQUENCE   282 AA;  31496 MW;  A9227787DB2F4C9A CRC64;
     MSVVSLLGVK IVNNPAPFLA PYQFEITFEC LEQLQKDLEW KLTYVGSATS SEYDQELDSL
     LVGPIPVGVN KFLFEADAPD LKRIPTSEIL GVTVILLTCS YDGREFVRVG YYVNNEYDSE
     ELTQDPPAKP IIERIRRNIL AEKPRVTRFA IKWDSEEDAP AEYPPDQPEA DLEDDGAAYG
     AEEAELEAAL IRELEEAERE AAKGGDHEME GAEETAGKDD EEEDLSDAES EDIEDESDDE
     EDDLDEDEGG DRDEDVEMGD DTESKDTNAA SGHHQQQDIM VH
 
 
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