ID   P19_CRV                 Reviewed;         172 AA.
AC   P17457;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=RNA silencing suppressor p19;
DE   AltName: Full=19 kDa symptom severity modulator;
GN   ORFNames=ORF4;
OS   Cymbidium ringspot virus (CymRSV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Tolucaviricetes;
OC   Tolivirales; Tombusviridae; Procedovirinae; Tombusvirus.
OX   NCBI_TaxID=12144;
OH   NCBI_TaxID=14366; Cymbidium.
OH   NCBI_TaxID=3899; Trifolium repens (Creeping white clover).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2778443; DOI=10.1099/0022-1317-70-9-2533;
RA   Grieco F., Burgyan J., Russo M.;
RT   "Nucleotide sequence of the 3'-terminal region of cymbidium ringspot virus
RT   RNA.";
RL   J. Gen. Virol. 70:2533-2538(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2771646; DOI=10.1093/nar/17.15.6383;
RA   Grieco F., Burgyan J., Russo M.;
RT   "The nucleotide sequence of cymbidium ringspot virus RNA.";
RL   Nucleic Acids Res. 17:6383-6383(1989).
RN   [3]
RP   FUNCTION.
RX   PubMed=12065420; DOI=10.1093/emboj/cdf312;
RA   Silhavy D., Molnar A., Lucioli A., Szittya G., Hornyik C., Tavazza M.,
RA   Burgyan J.;
RT   "A viral protein suppresses RNA silencing and binds silencing-generated,
RT   21- to 25-nucleotide double-stranded RNAs.";
RL   EMBO J. 21:3070-3080(2002).
CC   -!- FUNCTION: Viral suppressor of RNA silencing which binds specifically to
CC       silencing RNAs (siRNAs). Acts as a molecular caliper to specifically
CC       select siRNAs based on the length of the duplex region of the RNA (By
CC       similarity). {ECO:0000250, ECO:0000269|PubMed:12065420}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the tombusvirus protein p19 family.
CC       {ECO:0000305}.
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DR   EMBL; X15511; CAA33535.1; -; Genomic_RNA.
DR   PIR; JS0271; NKVGD2.
DR   RefSeq; NP_613264.1; NC_003532.1.
DR   SMR; P17457; -.
DR   GeneID; 935903; -.
DR   KEGG; vg:935903; -.
DR   Proteomes; UP000008567; Genome.
DR   GO; GO:0044423; C:virion component; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.390.180; -; 1.
DR   InterPro; IPR004905; Tombusvirus_p19.
DR   InterPro; IPR036131; VP19_sf.
DR   Pfam; PF03220; Tombus_P19; 1.
DR   SUPFAM; SSF103145; SSF103145; 1.
PE   3: Inferred from homology;
KW   RNA-binding; Suppressor of RNA silencing.
FT   CHAIN           1..172
FT                   /note="RNA silencing suppressor p19"
FT                   /id="PRO_0000222874"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..172
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   172 AA;  19385 MW;  F1069F14366D5D48 CRC64;
     MERAIQGSDV REQADSECWD GGGGGTTSPF KLPDESPSLH EWRLHHSEES ENKDNPLGFK
     ESWSFGKVVF KRYLRYDGAE TSLHRALGSW ERDSVNDAAS RFLGLSQIGC TYSIRFRGTR
     LTLSGGSGTL QRLIEMAIRT KRTMLQPTPS EREGNVSRRR PEGTEAFKEE SE