P19_TBSVK
ID P19_TBSVK Reviewed; 172 AA.
AC P69517; P50627;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=RNA silencing suppressor p19;
DE AltName: Full=19 kDa symptom severity modulator;
GN ORFNames=ORF4;
OS Tomato bushy stunt virus (strain Ja9) (TBSV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Tolucaviricetes;
OC Tolivirales; Tombusviridae; Procedovirinae; Tombusvirus.
OX NCBI_TaxID=70158;
OH NCBI_TaxID=4072; Capsicum annuum (Capsicum pepper).
OH NCBI_TaxID=3749; Malus.
OH NCBI_TaxID=3766; Pyrus (pears).
OH NCBI_TaxID=4081; Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OH NCBI_TaxID=4111; Solanum melongena (Eggplant) (Aubergine).
OH NCBI_TaxID=29777; Tolmiea menziesii.
OH NCBI_TaxID=13305; Tulipa.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX AGRICOLA=IND20581771;
RA Luis-Areteaga M., Rodriguez-Cerezo E., Fraile A., Saez E.,
RA Garcia-Arenal F.;
RT "Different tomato bushy stunt virus strains cause disease outbreaks on
RT solanaceous crops in Spain.";
RL Phytopathology 86:535-542(1996).
CC -!- FUNCTION: Viral suppressor of RNA silencing which binds specifically to
CC silencing RNAs (siRNAs). Acts as a molecular caliper to specifically
CC select siRNAs based on the length of the duplex region of the RNA (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the tombusvirus protein p19 family.
CC {ECO:0000305}.
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DR EMBL; Z68898; CAA93130.1; -; Genomic_RNA.
DR PDB; 4J39; X-ray; 1.70 A; A=27-149.
DR PDB; 4J5V; X-ray; 2.15 A; A=27-149.
DR PDB; 4JGN; X-ray; 1.86 A; A=27-149.
DR PDB; 4JK0; X-ray; 2.30 A; D=27-149.
DR PDB; 4JNX; X-ray; 1.95 A; A/D=27-149.
DR PDB; 4KNQ; X-ray; 1.82 A; A=27-149.
DR PDB; 4KQ0; X-ray; 2.10 A; A/D=27-157.
DR PDB; 4KTG; X-ray; 1.92 A; A=27-149.
DR PDBsum; 4J39; -.
DR PDBsum; 4J5V; -.
DR PDBsum; 4JGN; -.
DR PDBsum; 4JK0; -.
DR PDBsum; 4JNX; -.
DR PDBsum; 4KNQ; -.
DR PDBsum; 4KQ0; -.
DR PDBsum; 4KTG; -.
DR SMR; P69517; -.
DR GO; GO:0044423; C:virion component; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.390.180; -; 1.
DR InterPro; IPR004905; Tombusvirus_p19.
DR InterPro; IPR036131; VP19_sf.
DR Pfam; PF03220; Tombus_P19; 1.
DR SUPFAM; SSF103145; SSF103145; 1.
PE 1: Evidence at protein level;
KW 3D-structure; RNA-binding; Suppressor of RNA silencing.
FT CHAIN 1..172
FT /note="RNA silencing suppressor p19"
FT /id="PRO_0000222883"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT STRAND 29..32
FT /evidence="ECO:0007829|PDB:4JK0"
FT HELIX 39..48
FT /evidence="ECO:0007829|PDB:4J39"
FT TURN 52..54
FT /evidence="ECO:0007829|PDB:4JGN"
FT STRAND 57..65
FT /evidence="ECO:0007829|PDB:4J39"
FT STRAND 68..75
FT /evidence="ECO:0007829|PDB:4J39"
FT HELIX 80..87
FT /evidence="ECO:0007829|PDB:4J39"
FT HELIX 92..100
FT /evidence="ECO:0007829|PDB:4J39"
FT STRAND 104..106
FT /evidence="ECO:0007829|PDB:4J39"
FT STRAND 109..116
FT /evidence="ECO:0007829|PDB:4J39"
FT STRAND 119..126
FT /evidence="ECO:0007829|PDB:4J39"
FT HELIX 127..129
FT /evidence="ECO:0007829|PDB:4J39"
FT HELIX 130..146
FT /evidence="ECO:0007829|PDB:4J39"
SQ SEQUENCE 172 AA; 19364 MW; 72D0100B5C90AB8B CRC64;
MERAIQGNDA REQANSERWD GGSGGTTSPF KLPDESPSWT EWRLHNDETN SNQDNPLGFK
ESWGFGKVVF KRYLRYDRTE ASLHRVLGSW TGDSVNYAAS RFFGFDQIGC TYSIRFRGVS
ITVSGGSRTL QHLCEMAIRS KQELLQLAPI EVESNVSRGC PEGTQTFEKE GE
